Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions Article Swipe
Tsung-Ting Kuo
,
Anh T. Pham
,
Maxim Edelson
,
Jihoon Kim
,
Jason R. Chan
,
Yash P. Gupta
,
Lucila Ohno‐Machado
,
David M. Anderson
,
Chandrasekar Balacha
,
Tyler Bath
,
Sally L. Baxter
,
Andrea Becker-Pennrich
,
Douglas S. Bell
,
Elmer V. Bernstam
,
Chau Ngan
,
Michele E. Day
,
Jason N. Doctor
,
Scott L. DuVall
,
Robert El‐Kareh
,
Renato Florian
,
Robert W Follett
,
Benjamin P. Geisler
,
Alessandro Ghigi
,
Assaf Gottlieb
,
Ludwig Christian Hinske
,
Zhaoxian Hu
,
Diana Ir
,
Xiaoqian Jiang
,
Katherine Kim
,
Jihoon Kim
,
Tara K. Knight
,
Jejo Koola
,
Tsung-Ting Kuo
,
Nelson Lee
,
Ulrich Mansmann
,
Michael E. Matheny
,
Daniella Meeker
,
Zongyang Mou
,
Larissa Neumann
,
Nghia Nguyen
,
Anderson Nick
,
Lucila Ohno‐Machado
,
Eunice Park
,
Paulina Paul
,
Mark J. Pletcher
,
Kai Post
,
Clemens Rieder
,
Clemens Scherer
,
Lisa M. Schilling
,
Andrey Coatrini Soares
,
Spencer L. SooHoo
,
Ekin Soysal
,
Covington Steven
,
Brian Tep
,
Brian C. Toy
,
Baocheng Wang
,
Zhen R Wu
,
Hua Xu
,
Choi Jae Yong
,
Kai Zheng
,
Yujia Zhou
,
Rachel A Zucker
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/jamia/ocad049
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1093/jamia/ocad049
Objective We aimed to develop a distributed, immutable, and highly available cross-cloud blockchain system to facilitate federated data analysis activities among multiple institutions. Materials and Methods We preprocessed 9166 COVID-19 Structured Query Language (SQL) code, summary statistics, and user activity logs, from the GitHub repository of the Reliable Response Data Discovery for COVID-19 (R2D2) Consortium. The repository collected local summary statistics from participating institutions and aggregated the global result to a COVID-19-related clinical query, previously posted by clinicians on a website. We developed both on-chain and off-chain components to store/query these activity logs and their associated queries/results on a blockchain for immutability, transparency, and high availability of research communication. We measured run-time efficiency of contract deployment, network transactions, and confirmed the accuracy of recorded logs compared to a centralized baseline solution. Results The smart contract deployment took 4.5 s on an average. The time to record an activity log on blockchain was slightly over 2 s, versus 5–9 s for baseline. For querying, each query took on an average less than 0.4 s on blockchain, versus around 2.1 s for baseline. Discussion The low deployment, recording, and querying times confirm the feasibility of our cross-cloud, blockchain-based federated data analysis system. We have yet to evaluate the system on a larger network with multiple nodes per cloud, to consider how to accommodate a surge in activities, and to investigate methods to lower querying time as the blockchain grows. Conclusion Blockchain technology can be used to support federated data analysis among multiple institutions.
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Metadata
- Type
- article
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- en
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- https://doi.org/10.1093/jamia/ocad049
- https://academic.oup.com/jamia/advance-article-pdf/doi/10.1093/jamia/ocad049/49521647/ocad049.pdf
- OA Status
- hybrid
- Cited By
- 15
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4324129425
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4324129425Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/jamia/ocad049Digital Object Identifier
- Title
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Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutionsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-03-14Full publication date if available
- Authors
-
Tsung-Ting Kuo, Anh T. Pham, Maxim Edelson, Jihoon Kim, Jason R. Chan, Yash P. Gupta, Lucila Ohno‐Machado, David M. Anderson, Chandrasekar Balacha, Tyler Bath, Sally L. Baxter, Andrea Becker-Pennrich, Douglas S. Bell, Elmer V. Bernstam, Chau Ngan, Michele E. Day, Jason N. Doctor, Scott L. DuVall, Robert El‐Kareh, Renato Florian, Robert W Follett, Benjamin P. Geisler, Alessandro Ghigi, Assaf Gottlieb, Ludwig Christian Hinske, Zhaoxian Hu, Diana Ir, Xiaoqian Jiang, Katherine Kim, Jihoon Kim, Tara K. Knight, Jejo Koola, Tsung-Ting Kuo, Nelson Lee, Ulrich Mansmann, Michael E. Matheny, Daniella Meeker, Zongyang Mou, Larissa Neumann, Nghia Nguyen, Anderson Nick, Lucila Ohno‐Machado, Eunice Park, Paulina Paul, Mark J. Pletcher, Kai Post, Clemens Rieder, Clemens Scherer, Lisa M. Schilling, Andrey Coatrini Soares, Spencer L. SooHoo, Ekin Soysal, Covington Steven, Brian Tep, Brian C. Toy, Baocheng Wang, Zhen R Wu, Hua Xu, Choi Jae Yong, Kai Zheng, Yujia Zhou, Rachel A ZuckerList of authors in order
- Landing page
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https://doi.org/10.1093/jamia/ocad049Publisher landing page
- PDF URL
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https://academic.oup.com/jamia/advance-article-pdf/doi/10.1093/jamia/ocad049/49521647/ocad049.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://academic.oup.com/jamia/advance-article-pdf/doi/10.1093/jamia/ocad049/49521647/ocad049.pdfDirect OA link when available
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Blockchain, Computer science, Baseline (sea), Software deployment, Cloud computing, Smart contract, Metadata, Database, Transparency (behavior), World Wide Web, Computer security, Operating system, Geology, OceanographyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
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2025: 3, 2024: 9, 2023: 3Per-year citation counts (last 5 years)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.statistics, | 37 |
| abstract_inverted_index.store/query | 90 |
| abstract_inverted_index.availability | 106 |
| abstract_inverted_index.cross-cloud, | 195 |
| abstract_inverted_index.distributed, | 7 |
| abstract_inverted_index.institutions | 64 |
| abstract_inverted_index.preprocessed | 28 |
| abstract_inverted_index.immutability, | 102 |
| abstract_inverted_index.institutions. | 23, 251 |
| abstract_inverted_index.participating | 63 |
| abstract_inverted_index.transactions, | 118 |
| abstract_inverted_index.transparency, | 103 |
| abstract_inverted_index.communication. | 109 |
| abstract_inverted_index.queries/results | 97 |
| abstract_inverted_index.COVID-19-related | 72 |
| abstract_inverted_index.blockchain-based | 196 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5046477105, https://openalex.org/A5046477105 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 62 |
| corresponding_institution_ids | https://openalex.org/I36258959 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/17 |
| sustainable_development_goals[0].score | 0.4399999976158142 |
| sustainable_development_goals[0].display_name | Partnerships for the goals |
| citation_normalized_percentile.value | 0.92886892 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |