Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve Article Swipe
Melissa Gresle
,
Yaou Liu
,
Trevor J. Kilpatrick
,
Dennis Kemper
,
Qizhu Wu
,
Bing Hu
,
Qing‐Ling Fu
,
Kwok‐Fai So
,
Guoqing Sheng
,
Guanrong Huang
,
Blake Pepinsky
,
Helmut Butzkueven
,
Sha Mi
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1177/2055217316641704
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1177/2055217316641704
Background Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Across a range of experimental models, LINGO-1 has been found to inhibit neuron and oligodendrocyte survival, axon regeneration, and (re)myelination. The therapeutic effects of anti-LINGO-1 antibodies on optic nerve axonal loss and regeneration have not yet been investigated. Objective In this series of studies we investigate if LINGO-1 antibodies can prevent acute inflammatory axonal loss, and promote axonal regeneration after injury in rodent optic nerves. Methods The effects of anti-LINGO-1 antibody on optic nerve axonal damage were assessed using rodent myelin oligodendrocyte glycoprotein experimental autoimmune encephalomyelitis (EAE), and its effects on axonal regeneration were assessed in optic nerve crush injury models. Results In the optic nerve, anti-LINGO-1 antibody therapy was associated with improved optic nerve parallel diffusivity measures on MRI in mice with EAE and reduced axonal loss in rat EAE. Both anti-LINGO-1 antibody therapy and the genetic deletion of LINGO-1 reduced nerve crush-induced axonal degeneration and enhanced axonal regeneration. Conclusion These data demonstrate that LINGO-1 blockade is associated with axonal protection and regeneration in the injured optic nerve.
Related Topics
Concepts
Optic nerve
Regeneration (biology)
Axon
Myelin oligodendrocyte glycoprotein
Myelin
Neuroscience
Oligodendrocyte
Optic neuritis
Experimental autoimmune encephalomyelitis
Medicine
Multiple sclerosis
Retinal ganglion cell
Pathology
Biology
Immunology
Central nervous system
Cell biology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/2055217316641704
- https://journals.sagepub.com/doi/pdf/10.1177/2055217316641704
- OA Status
- gold
- Cited By
- 16
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2339704287
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2339704287Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/2055217316641704Digital Object Identifier
- Title
-
Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerveWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-01-01Full publication date if available
- Authors
-
Melissa Gresle, Yaou Liu, Trevor J. Kilpatrick, Dennis Kemper, Qizhu Wu, Bing Hu, Qing‐Ling Fu, Kwok‐Fai So, Guoqing Sheng, Guanrong Huang, Blake Pepinsky, Helmut Butzkueven, Sha MiList of authors in order
- Landing page
-
https://doi.org/10.1177/2055217316641704Publisher landing page
- PDF URL
-
https://journals.sagepub.com/doi/pdf/10.1177/2055217316641704Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://journals.sagepub.com/doi/pdf/10.1177/2055217316641704Direct OA link when available
- Concepts
-
Optic nerve, Regeneration (biology), Axon, Myelin oligodendrocyte glycoprotein, Myelin, Neuroscience, Oligodendrocyte, Optic neuritis, Experimental autoimmune encephalomyelitis, Medicine, Multiple sclerosis, Retinal ganglion cell, Pathology, Biology, Immunology, Central nervous system, Cell biologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
16Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 1, 2022: 2, 2021: 4, 2020: 4Per-year citation counts (last 5 years)
- References (count)
-
35Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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