Blood Brain Barrier‐Crossing Delivery of Felodipine Nanodrug Ameliorates Anxiety‐Like Behavior and Cognitive Impairment in Alzheimer's Disease Article Swipe
Xiaofei He
,
Yuan Peng
,
Sicong Huang
,
Zecong Xiao
,
Ge Li
,
Zejie Zuo
,
Liying Zhang
,
Xintao Shuai
,
Haiqing Zheng
,
Xiquan Hu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202401731
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202401731
Alzheimer's disease (AD) is the most common age‐related neurodegenerative disorder leading to cognitive decline. Excessive cytosolic calcium (Ca 2+ ) accumulation plays a critical role in the pathogenesis of AD since it activates the NOD‐like receptor family, pyrin domain containing 3 (NLRP3), switches the endoplasmic reticulum (ER) unfolded protein response (UPR) toward proapoptotic signaling and promotes A β seeding. Herein, a liposomal nanodrug (felodipine@LND) is developed incorporating a calcium channel antagonist felodipine for Alzheimer's disease treatment through a low‐intensity pulse ultrasound (LIPUS) irradiation‐assisted blood brain barrier (BBB)‐crossing drug delivery. The multifunctional felodipine@LND is effectively delivered to diseased brain through applying a LIPUS irradiation to the skull, which resulted in a series of positive effects against AD. Markedly, the nanodrug treatment switched the ER UPR toward antioxidant signaling, prevented the surface translocation of ER calreticulin (CALR) in microglia, and inhibited the NLRP3 activation and A β seeding. In addition, it promoted the degradation of damaged mitochondria via mitophagy, thereby inhibiting the neuronal apoptosis. Therefore, the anxiety‐like behavior and cognitive impairment of 5xFAD mice with AD is significantly ameliorated, which manifested the potential of LIPUS – assisted BBB‐crossing delivery of felodipine@LND to serve as a paradigm for AD therapy based on the well‐recognized clinically available felodipine.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/advs.202401731
- OA Status
- gold
- Cited By
- 18
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400446709
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4400446709Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/advs.202401731Digital Object Identifier
- Title
-
Blood Brain Barrier‐Crossing Delivery of Felodipine Nanodrug Ameliorates Anxiety‐Like Behavior and Cognitive Impairment in Alzheimer's DiseaseWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-07-09Full publication date if available
- Authors
-
Xiaofei He, Yuan Peng, Sicong Huang, Zecong Xiao, Ge Li, Zejie Zuo, Liying Zhang, Xintao Shuai, Haiqing Zheng, Xiquan HuList of authors in order
- Landing page
-
https://doi.org/10.1002/advs.202401731Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1002/advs.202401731Direct OA link when available
- Concepts
-
Felodipine, Medicine, Pharmacology, Neuroinflammation, Cognitive decline, Endocrinology, Internal medicine, Inflammation, Disease, Blood pressure, DementiaTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 15, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4400446709 |
|---|---|
| doi | https://doi.org/10.1002/advs.202401731 |
| ids.doi | https://doi.org/10.1002/advs.202401731 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38981028 |
| ids.openalex | https://openalex.org/W4400446709 |
| fwci | 11.71373773 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000188 |
| mesh[1].descriptor_ui | D000544 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | drug therapy |
| mesh[1].descriptor_name | Alzheimer Disease |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D000544 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Alzheimer Disease |
| mesh[3].qualifier_ui | Q000187 |
| mesh[3].descriptor_ui | D001812 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | drug effects |
| mesh[3].descriptor_name | Blood-Brain Barrier |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D001812 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Blood-Brain Barrier |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D051379 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Mice |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D004195 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Disease Models, Animal |
| mesh[7].qualifier_ui | Q000188 |
| mesh[7].descriptor_ui | D060825 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | drug therapy |
| mesh[7].descriptor_name | Cognitive Dysfunction |
| mesh[8].qualifier_ui | Q000494 |
| mesh[8].descriptor_ui | D015736 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | pharmacology |
| mesh[8].descriptor_name | Felodipine |
| mesh[9].qualifier_ui | Q000188 |
| mesh[9].descriptor_ui | D001007 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | drug therapy |
| mesh[9].descriptor_name | Anxiety |
| mesh[10].qualifier_ui | Q000379 |
| mesh[10].descriptor_ui | D016503 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | methods |
| mesh[10].descriptor_name | Drug Delivery Systems |
| mesh[11].qualifier_ui | Q000187 |
| mesh[11].descriptor_ui | D001522 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | drug effects |
| mesh[11].descriptor_name | Behavior, Animal |
| mesh[12].qualifier_ui | Q000494 |
| mesh[12].descriptor_ui | D002121 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | pharmacology |
| mesh[12].descriptor_name | Calcium Channel Blockers |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D000818 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Animals |
| mesh[14].qualifier_ui | Q000188 |
| mesh[14].descriptor_ui | D000544 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | drug therapy |
| mesh[14].descriptor_name | Alzheimer Disease |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D000544 |
| mesh[15].is_major_topic | True |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Alzheimer Disease |
| mesh[16].qualifier_ui | Q000187 |
| mesh[16].descriptor_ui | D001812 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | drug effects |
| mesh[16].descriptor_name | Blood-Brain Barrier |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D001812 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Blood-Brain Barrier |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D051379 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Mice |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D004195 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Disease Models, Animal |
| mesh[20].qualifier_ui | Q000188 |
| mesh[20].descriptor_ui | D060825 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | drug therapy |
| mesh[20].descriptor_name | Cognitive Dysfunction |
| mesh[21].qualifier_ui | Q000494 |
| mesh[21].descriptor_ui | D015736 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | pharmacology |
| mesh[21].descriptor_name | Felodipine |
| mesh[22].qualifier_ui | Q000188 |
| mesh[22].descriptor_ui | D001007 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | drug therapy |
| mesh[22].descriptor_name | Anxiety |
| mesh[23].qualifier_ui | Q000379 |
| mesh[23].descriptor_ui | D016503 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | methods |
| mesh[23].descriptor_name | Drug Delivery Systems |
| mesh[24].qualifier_ui | Q000187 |
| mesh[24].descriptor_ui | D001522 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | drug effects |
| mesh[24].descriptor_name | Behavior, Animal |
| mesh[25].qualifier_ui | Q000494 |
| mesh[25].descriptor_ui | D002121 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | pharmacology |
| mesh[25].descriptor_name | Calcium Channel Blockers |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D000818 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Animals |
| mesh[27].qualifier_ui | Q000188 |
| mesh[27].descriptor_ui | D000544 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | drug therapy |
| mesh[27].descriptor_name | Alzheimer Disease |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D000544 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | Alzheimer Disease |
| mesh[29].qualifier_ui | Q000187 |
| mesh[29].descriptor_ui | D001812 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | drug effects |
| mesh[29].descriptor_name | Blood-Brain Barrier |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D001812 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Blood-Brain Barrier |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D051379 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Mice |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D004195 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Disease Models, Animal |
| mesh[33].qualifier_ui | Q000188 |
| mesh[33].descriptor_ui | D060825 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | drug therapy |
| mesh[33].descriptor_name | Cognitive Dysfunction |
| mesh[34].qualifier_ui | Q000494 |
| mesh[34].descriptor_ui | D015736 |
| mesh[34].is_major_topic | True |
| mesh[34].qualifier_name | pharmacology |
| mesh[34].descriptor_name | Felodipine |
| mesh[35].qualifier_ui | Q000188 |
| mesh[35].descriptor_ui | D001007 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | drug therapy |
| mesh[35].descriptor_name | Anxiety |
| mesh[36].qualifier_ui | Q000379 |
| mesh[36].descriptor_ui | D016503 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | methods |
| mesh[36].descriptor_name | Drug Delivery Systems |
| mesh[37].qualifier_ui | Q000187 |
| mesh[37].descriptor_ui | D001522 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | drug effects |
| mesh[37].descriptor_name | Behavior, Animal |
| mesh[38].qualifier_ui | Q000494 |
| mesh[38].descriptor_ui | D002121 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | pharmacology |
| mesh[38].descriptor_name | Calcium Channel Blockers |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D000818 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Animals |
| mesh[40].qualifier_ui | Q000188 |
| mesh[40].descriptor_ui | D000544 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | drug therapy |
| mesh[40].descriptor_name | Alzheimer Disease |
| mesh[41].qualifier_ui | Q000378 |
| mesh[41].descriptor_ui | D000544 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | metabolism |
| mesh[41].descriptor_name | Alzheimer Disease |
| mesh[42].qualifier_ui | Q000187 |
| mesh[42].descriptor_ui | D001812 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | drug effects |
| mesh[42].descriptor_name | Blood-Brain Barrier |
| mesh[43].qualifier_ui | Q000378 |
| mesh[43].descriptor_ui | D001812 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | metabolism |
| mesh[43].descriptor_name | Blood-Brain Barrier |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D051379 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Mice |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D004195 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Disease Models, Animal |
| mesh[46].qualifier_ui | Q000188 |
| mesh[46].descriptor_ui | D060825 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | drug therapy |
| mesh[46].descriptor_name | Cognitive Dysfunction |
| mesh[47].qualifier_ui | Q000494 |
| mesh[47].descriptor_ui | D015736 |
| mesh[47].is_major_topic | True |
| mesh[47].qualifier_name | pharmacology |
| mesh[47].descriptor_name | Felodipine |
| mesh[48].qualifier_ui | Q000188 |
| mesh[48].descriptor_ui | D001007 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | drug therapy |
| mesh[48].descriptor_name | Anxiety |
| mesh[49].qualifier_ui | Q000379 |
| mesh[49].descriptor_ui | D016503 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | methods |
| mesh[49].descriptor_name | Drug Delivery Systems |
| type | article |
| title | Blood Brain Barrier‐Crossing Delivery of Felodipine Nanodrug Ameliorates Anxiety‐Like Behavior and Cognitive Impairment in Alzheimer's Disease |
| biblio.issue | 34 |
| biblio.volume | 11 |
| biblio.last_page | e2401731 |
| biblio.first_page | e2401731 |
| grants[0].funder | https://openalex.org/F4320321001 |
| grants[0].award_id | 51933011 |
| grants[0].funder_display_name | National Natural Science Foundation of China |
| grants[1].funder | https://openalex.org/F4320321001 |
| grants[1].award_id | 82172546 |
| grants[1].funder_display_name | National Natural Science Foundation of China |
| grants[2].funder | https://openalex.org/F4320321001 |
| grants[2].award_id | 82272609 |
| grants[2].funder_display_name | National Natural Science Foundation of China |
| grants[3].funder | https://openalex.org/F4320335777 |
| grants[3].award_id | 2022YFC3601200 |
| grants[3].funder_display_name | National Key Research and Development Program of China |
| topics[0].id | https://openalex.org/T11150 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.987500011920929 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1307 |
| topics[0].subfield.display_name | Cell Biology |
| topics[0].display_name | Endoplasmic Reticulum Stress and Disease |
| topics[1].id | https://openalex.org/T12580 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9868999719619751 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2808 |
| topics[1].subfield.display_name | Neurology |
| topics[1].display_name | Vagus Nerve Stimulation Research |
| topics[2].id | https://openalex.org/T10958 |
| topics[2].field.id | https://openalex.org/fields/22 |
| topics[2].field.display_name | Engineering |
| topics[2].score | 0.9818000197410583 |
| topics[2].domain.id | https://openalex.org/domains/3 |
| topics[2].domain.display_name | Physical Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2204 |
| topics[2].subfield.display_name | Biomedical Engineering |
| topics[2].display_name | Ultrasound and Hyperthermia Applications |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320335777 |
| funders[1].ror | |
| funders[1].display_name | National Key Research and Development Program of China |
| is_xpac | False |
| apc_list.value | 5000 |
| apc_list.currency | USD |
| apc_list.value_usd | 5000 |
| apc_paid.value | 5000 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 5000 |
| concepts[0].id | https://openalex.org/C2780648877 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8170415163040161 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q420644 |
| concepts[0].display_name | Felodipine |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.5430341362953186 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C98274493 |
| concepts[2].level | 1 |
| concepts[2].score | 0.5113272070884705 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[2].display_name | Pharmacology |
| concepts[3].id | https://openalex.org/C87753298 |
| concepts[3].level | 3 |
| concepts[3].score | 0.47611814737319946 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q17157137 |
| concepts[3].display_name | Neuroinflammation |
| concepts[4].id | https://openalex.org/C2984863031 |
| concepts[4].level | 4 |
| concepts[4].score | 0.41447755694389343 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q83030 |
| concepts[4].display_name | Cognitive decline |
| concepts[5].id | https://openalex.org/C134018914 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3111048638820648 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[5].display_name | Endocrinology |
| concepts[6].id | https://openalex.org/C126322002 |
| concepts[6].level | 1 |
| concepts[6].score | 0.2774621248245239 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[6].display_name | Internal medicine |
| concepts[7].id | https://openalex.org/C2776914184 |
| concepts[7].level | 2 |
| concepts[7].score | 0.19641932845115662 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[7].display_name | Inflammation |
| concepts[8].id | https://openalex.org/C2779134260 |
| concepts[8].level | 2 |
| concepts[8].score | 0.13154101371765137 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[8].display_name | Disease |
| concepts[9].id | https://openalex.org/C84393581 |
| concepts[9].level | 2 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q82642 |
| concepts[9].display_name | Blood pressure |
| concepts[10].id | https://openalex.org/C2779483572 |
| concepts[10].level | 3 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q83030 |
| concepts[10].display_name | Dementia |
| keywords[0].id | https://openalex.org/keywords/felodipine |
| keywords[0].score | 0.8170415163040161 |
| keywords[0].display_name | Felodipine |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.5430341362953186 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/pharmacology |
| keywords[2].score | 0.5113272070884705 |
| keywords[2].display_name | Pharmacology |
| keywords[3].id | https://openalex.org/keywords/neuroinflammation |
| keywords[3].score | 0.47611814737319946 |
| keywords[3].display_name | Neuroinflammation |
| keywords[4].id | https://openalex.org/keywords/cognitive-decline |
| keywords[4].score | 0.41447755694389343 |
| keywords[4].display_name | Cognitive decline |
| keywords[5].id | https://openalex.org/keywords/endocrinology |
| keywords[5].score | 0.3111048638820648 |
| keywords[5].display_name | Endocrinology |
| keywords[6].id | https://openalex.org/keywords/internal-medicine |
| keywords[6].score | 0.2774621248245239 |
| keywords[6].display_name | Internal medicine |
| keywords[7].id | https://openalex.org/keywords/inflammation |
| keywords[7].score | 0.19641932845115662 |
| keywords[7].display_name | Inflammation |
| keywords[8].id | https://openalex.org/keywords/disease |
| keywords[8].score | 0.13154101371765137 |
| keywords[8].display_name | Disease |
| language | en |
| locations[0].id | doi:10.1002/advs.202401731 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2737737698 |
| locations[0].source.issn | 2198-3844 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2198-3844 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Advanced Science |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Advanced Science |
| locations[0].landing_page_url | https://doi.org/10.1002/advs.202401731 |
| locations[1].id | pmid:38981028 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Advanced science (Weinheim, Baden-Wurttemberg, Germany) |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38981028 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11425895 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Adv Sci (Weinh) |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11425895 |
| locations[3].id | pmh:oai:doaj.org/article:80f61ac8c86f43b184eab4f0d9c7a23a |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024) |
| locations[3].landing_page_url | https://doaj.org/article/80f61ac8c86f43b184eab4f0d9c7a23a |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5031574668 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2983-0289 |
| authorships[0].author.display_name | Xiaofei He |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I157773358, https://openalex.org/I4210146956 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| authorships[0].institutions[0].id | https://openalex.org/I157773358 |
| authorships[0].institutions[0].ror | https://ror.org/0064kty71 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I157773358 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Sun Yat-sen University |
| authorships[0].institutions[1].id | https://openalex.org/I4210146956 |
| authorships[0].institutions[1].ror | https://ror.org/04tm3k558 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I4210146956 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | Third Affiliated Hospital of Sun Yat-sen University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Xiaofei He |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| authorships[1].author.id | https://openalex.org/A5054001373 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-8414-6055 |
| authorships[1].author.display_name | Yuan Peng |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210116575, https://openalex.org/I92039509 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Rehabilitation Medicine Guangzhou First People's Hospital Guangzhou 510180 China |
| authorships[1].institutions[0].id | https://openalex.org/I4210116575 |
| authorships[1].institutions[0].ror | https://ror.org/02bwytq13 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210116575 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Guangzhou First People's Hospital |
| authorships[1].institutions[1].id | https://openalex.org/I92039509 |
| authorships[1].institutions[1].ror | https://ror.org/00zat6v61 |
| authorships[1].institutions[1].type | education |
| authorships[1].institutions[1].lineage | https://openalex.org/I92039509 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | Guangzhou Medical University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yuan Peng |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Rehabilitation Medicine Guangzhou First People's Hospital Guangzhou 510180 China |
| authorships[2].author.id | https://openalex.org/A5043900893 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-0854-4734 |
| authorships[2].author.display_name | Sicong Huang |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I157773358 |
| authorships[2].affiliations[0].raw_affiliation_string | School of Materials Science and Engineering Sun Yat‐sen University Guangzhou 510275 China |
| authorships[2].institutions[0].id | https://openalex.org/I157773358 |
| authorships[2].institutions[0].ror | https://ror.org/0064kty71 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I157773358 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Sun Yat-sen University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sicong Huang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | School of Materials Science and Engineering Sun Yat‐sen University Guangzhou 510275 China |
| authorships[3].author.id | https://openalex.org/A5009858516 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-7923-5309 |
| authorships[3].author.display_name | Zecong Xiao |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I157773358, https://openalex.org/I4210146956 |
| authorships[3].affiliations[0].raw_affiliation_string | Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou 510630 China |
| authorships[3].institutions[0].id | https://openalex.org/I157773358 |
| authorships[3].institutions[0].ror | https://ror.org/0064kty71 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I157773358 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Sun Yat-sen University |
| authorships[3].institutions[1].id | https://openalex.org/I4210146956 |
| authorships[3].institutions[1].ror | https://ror.org/04tm3k558 |
| authorships[3].institutions[1].type | healthcare |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210146956 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Third Affiliated Hospital of Sun Yat-sen University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Zecong Xiao |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou 510630 China |
| authorships[4].author.id | https://openalex.org/A5100447685 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-7279-3068 |
| authorships[4].author.display_name | Ge Li |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210131955 |
| authorships[4].affiliations[0].raw_affiliation_string | Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring Institute 11 Fengxin Road Guangzhou Guangdong 510663 China |
| authorships[4].institutions[0].id | https://openalex.org/I4210131955 |
| authorships[4].institutions[0].ror | https://ror.org/02mxq6q49 |
| authorships[4].institutions[0].type | facility |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210131955 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Guangdong Laboratory Animals Monitoring Institute |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ge Li |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring Institute 11 Fengxin Road Guangzhou Guangdong 510663 China |
| authorships[5].author.id | https://openalex.org/A5073218826 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-4035-8731 |
| authorships[5].author.display_name | Zejie Zuo |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I157773358, https://openalex.org/I4210146956 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| authorships[5].institutions[0].id | https://openalex.org/I157773358 |
| authorships[5].institutions[0].ror | https://ror.org/0064kty71 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I157773358 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Sun Yat-sen University |
| authorships[5].institutions[1].id | https://openalex.org/I4210146956 |
| authorships[5].institutions[1].ror | https://ror.org/04tm3k558 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I4210146956 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | Third Affiliated Hospital of Sun Yat-sen University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Zejie Zuo |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| authorships[6].author.id | https://openalex.org/A5100357097 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9969-4561 |
| authorships[6].author.display_name | Liying Zhang |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I157773358, https://openalex.org/I4210146956 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| authorships[6].institutions[0].id | https://openalex.org/I157773358 |
| authorships[6].institutions[0].ror | https://ror.org/0064kty71 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I157773358 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Sun Yat-sen University |
| authorships[6].institutions[1].id | https://openalex.org/I4210146956 |
| authorships[6].institutions[1].ror | https://ror.org/04tm3k558 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I4210146956 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Third Affiliated Hospital of Sun Yat-sen University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Liying Zhang |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| authorships[7].author.id | https://openalex.org/A5033843685 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4271-0310 |
| authorships[7].author.display_name | Xintao Shuai |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I157773358, https://openalex.org/I4210146956 |
| authorships[7].affiliations[0].raw_affiliation_string | Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou 510630 China |
| authorships[7].institutions[0].id | https://openalex.org/I157773358 |
| authorships[7].institutions[0].ror | https://ror.org/0064kty71 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I157773358 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Sun Yat-sen University |
| authorships[7].institutions[1].id | https://openalex.org/I4210146956 |
| authorships[7].institutions[1].ror | https://ror.org/04tm3k558 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I4210146956 |
| authorships[7].institutions[1].country_code | CN |
| authorships[7].institutions[1].display_name | Third Affiliated Hospital of Sun Yat-sen University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Xintao Shuai |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou 510630 China |
| authorships[8].author.id | https://openalex.org/A5100666268 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-7385-3037 |
| authorships[8].author.display_name | Haiqing Zheng |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I157773358, https://openalex.org/I4210146956 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| authorships[8].institutions[0].id | https://openalex.org/I157773358 |
| authorships[8].institutions[0].ror | https://ror.org/0064kty71 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I157773358 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Sun Yat-sen University |
| authorships[8].institutions[1].id | https://openalex.org/I4210146956 |
| authorships[8].institutions[1].ror | https://ror.org/04tm3k558 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I4210146956 |
| authorships[8].institutions[1].country_code | CN |
| authorships[8].institutions[1].display_name | Third Affiliated Hospital of Sun Yat-sen University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Haiqing Zheng |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| authorships[9].author.id | https://openalex.org/A5079593300 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-5554-6903 |
| authorships[9].author.display_name | Xiquan Hu |
| authorships[9].countries | CN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I157773358, https://openalex.org/I4210146956 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| authorships[9].institutions[0].id | https://openalex.org/I157773358 |
| authorships[9].institutions[0].ror | https://ror.org/0064kty71 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I157773358 |
| authorships[9].institutions[0].country_code | CN |
| authorships[9].institutions[0].display_name | Sun Yat-sen University |
| authorships[9].institutions[1].id | https://openalex.org/I4210146956 |
| authorships[9].institutions[1].ror | https://ror.org/04tm3k558 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I4210146956 |
| authorships[9].institutions[1].country_code | CN |
| authorships[9].institutions[1].display_name | Third Affiliated Hospital of Sun Yat-sen University |
| authorships[9].author_position | last |
| authorships[9].raw_author_name | Xiquan Hu |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Rehabilitation Medicine The Third Affiliated Hospital Sun Yat‐sen University 600 Tianhe Road Guangzhou Guangdong 510630 China |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.1002/advs.202401731 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Blood Brain Barrier‐Crossing Delivery of Felodipine Nanodrug Ameliorates Anxiety‐Like Behavior and Cognitive Impairment in Alzheimer's Disease |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11150 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.987500011920929 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1307 |
| primary_topic.subfield.display_name | Cell Biology |
| primary_topic.display_name | Endoplasmic Reticulum Stress and Disease |
| related_works | https://openalex.org/W2748952813, https://openalex.org/W4391375266, https://openalex.org/W2375776082, https://openalex.org/W2090028217, https://openalex.org/W2034497865, https://openalex.org/W2054543578, https://openalex.org/W2136763181, https://openalex.org/W2029345299, https://openalex.org/W1983211022, https://openalex.org/W2373391054 |
| cited_by_count | 18 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 15 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1002/advs.202401731 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2737737698 |
| best_oa_location.source.issn | 2198-3844 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2198-3844 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Advanced Science |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Advanced Science |
| best_oa_location.landing_page_url | https://doi.org/10.1002/advs.202401731 |
| primary_location.id | doi:10.1002/advs.202401731 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2737737698 |
| primary_location.source.issn | 2198-3844 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2198-3844 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Advanced Science |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Advanced Science |
| primary_location.landing_page_url | https://doi.org/10.1002/advs.202401731 |
| publication_date | 2024-07-09 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4206046172, https://openalex.org/W3092068755, https://openalex.org/W4321482316, https://openalex.org/W4389070490, https://openalex.org/W4391885892, https://openalex.org/W3209041513, https://openalex.org/W2954390789, https://openalex.org/W2953948138, https://openalex.org/W2976163884, https://openalex.org/W3152525961, https://openalex.org/W2524123352, https://openalex.org/W3011845531, https://openalex.org/W2897087128, https://openalex.org/W2941354401, https://openalex.org/W2774690079, https://openalex.org/W3194032198, https://openalex.org/W2974222077, https://openalex.org/W3015575990, https://openalex.org/W2424320469, https://openalex.org/W604311899, https://openalex.org/W2922119122, https://openalex.org/W2029961893, https://openalex.org/W1976964146, https://openalex.org/W2809566724, https://openalex.org/W4283311780, https://openalex.org/W4327966055, https://openalex.org/W4281642562, https://openalex.org/W2950651305, https://openalex.org/W3092954212, https://openalex.org/W2433010802, https://openalex.org/W4390547811, https://openalex.org/W4377020415, https://openalex.org/W4380480552, https://openalex.org/W2885738829, https://openalex.org/W2067632426, https://openalex.org/W2769404035, https://openalex.org/W3096916956, https://openalex.org/W2119098586, https://openalex.org/W2996716861, https://openalex.org/W2788480107, https://openalex.org/W4385498418, https://openalex.org/W4298127835, https://openalex.org/W2911248861, https://openalex.org/W2613163105, https://openalex.org/W2198453507, https://openalex.org/W4366383240, https://openalex.org/W2135179728, https://openalex.org/W4320727015, https://openalex.org/W4294733093, https://openalex.org/W4384663852, https://openalex.org/W174130975, https://openalex.org/W4220954708, https://openalex.org/W2157717331, https://openalex.org/W2804065209, https://openalex.org/W2354779203, https://openalex.org/W2003966687, https://openalex.org/W1994580609, https://openalex.org/W4308580592, https://openalex.org/W4400446709, https://openalex.org/W4206774749, https://openalex.org/W274505737, https://openalex.org/W2904244708, https://openalex.org/W4237142329 |
| referenced_works_count | 63 |
| abstract_inverted_index.) | 20 |
| abstract_inverted_index.3 | 41 |
| abstract_inverted_index.A | 57, 144 |
| abstract_inverted_index.a | 23, 61, 68, 78, 101, 110, 193 |
| abstract_inverted_index.2+ | 19 |
| abstract_inverted_index.AD | 30, 174, 196 |
| abstract_inverted_index.ER | 123, 133 |
| abstract_inverted_index.In | 147 |
| abstract_inverted_index.as | 192 |
| abstract_inverted_index.in | 26, 109, 136 |
| abstract_inverted_index.is | 4, 65, 93, 175 |
| abstract_inverted_index.it | 32, 149 |
| abstract_inverted_index.of | 29, 112, 132, 153, 170, 182, 188 |
| abstract_inverted_index.on | 199 |
| abstract_inverted_index.to | 12, 96, 104, 190 |
| abstract_inverted_index.β | 58, 145 |
| abstract_inverted_index.(Ca | 18 |
| abstract_inverted_index.AD. | 116 |
| abstract_inverted_index.The | 90 |
| abstract_inverted_index.UPR | 124 |
| abstract_inverted_index.and | 55, 138, 143, 167 |
| abstract_inverted_index.for | 73, 195 |
| abstract_inverted_index.the | 5, 27, 34, 44, 105, 118, 122, 129, 140, 151, 160, 164, 180, 200 |
| abstract_inverted_index.via | 156 |
| abstract_inverted_index.– | 184 |
| abstract_inverted_index.(AD) | 3 |
| abstract_inverted_index.(ER) | 47 |
| abstract_inverted_index.drug | 88 |
| abstract_inverted_index.mice | 172 |
| abstract_inverted_index.most | 6 |
| abstract_inverted_index.role | 25 |
| abstract_inverted_index.with | 173 |
| abstract_inverted_index.(UPR) | 51 |
| abstract_inverted_index.5xFAD | 171 |
| abstract_inverted_index.LIPUS | 102, 183 |
| abstract_inverted_index.NLRP3 | 141 |
| abstract_inverted_index.based | 198 |
| abstract_inverted_index.blood | 84 |
| abstract_inverted_index.brain | 85, 98 |
| abstract_inverted_index.plays | 22 |
| abstract_inverted_index.pulse | 80 |
| abstract_inverted_index.pyrin | 38 |
| abstract_inverted_index.serve | 191 |
| abstract_inverted_index.since | 31 |
| abstract_inverted_index.which | 107, 178 |
| abstract_inverted_index.(CALR) | 135 |
| abstract_inverted_index.common | 7 |
| abstract_inverted_index.domain | 39 |
| abstract_inverted_index.series | 111 |
| abstract_inverted_index.skull, | 106 |
| abstract_inverted_index.toward | 52, 125 |
| abstract_inverted_index.(LIPUS) | 82 |
| abstract_inverted_index.Herein, | 60 |
| abstract_inverted_index.against | 115 |
| abstract_inverted_index.barrier | 86 |
| abstract_inverted_index.calcium | 17, 69 |
| abstract_inverted_index.channel | 70 |
| abstract_inverted_index.damaged | 154 |
| abstract_inverted_index.disease | 2, 75 |
| abstract_inverted_index.effects | 114 |
| abstract_inverted_index.family, | 37 |
| abstract_inverted_index.leading | 11 |
| abstract_inverted_index.protein | 49 |
| abstract_inverted_index.surface | 130 |
| abstract_inverted_index.therapy | 197 |
| abstract_inverted_index.thereby | 158 |
| abstract_inverted_index.through | 77, 99 |
| abstract_inverted_index.(NLRP3), | 42 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.applying | 100 |
| abstract_inverted_index.assisted | 185 |
| abstract_inverted_index.behavior | 166 |
| abstract_inverted_index.critical | 24 |
| abstract_inverted_index.decline. | 14 |
| abstract_inverted_index.delivery | 187 |
| abstract_inverted_index.diseased | 97 |
| abstract_inverted_index.disorder | 10 |
| abstract_inverted_index.nanodrug | 63, 119 |
| abstract_inverted_index.neuronal | 161 |
| abstract_inverted_index.paradigm | 194 |
| abstract_inverted_index.positive | 113 |
| abstract_inverted_index.promoted | 150 |
| abstract_inverted_index.promotes | 56 |
| abstract_inverted_index.receptor | 36 |
| abstract_inverted_index.response | 50 |
| abstract_inverted_index.resulted | 108 |
| abstract_inverted_index.seeding. | 59, 146 |
| abstract_inverted_index.switched | 121 |
| abstract_inverted_index.switches | 43 |
| abstract_inverted_index.unfolded | 48 |
| abstract_inverted_index.Excessive | 15 |
| abstract_inverted_index.Markedly, | 117 |
| abstract_inverted_index.activates | 33 |
| abstract_inverted_index.addition, | 148 |
| abstract_inverted_index.available | 203 |
| abstract_inverted_index.cognitive | 13, 168 |
| abstract_inverted_index.cytosolic | 16 |
| abstract_inverted_index.delivered | 95 |
| abstract_inverted_index.delivery. | 89 |
| abstract_inverted_index.developed | 66 |
| abstract_inverted_index.inhibited | 139 |
| abstract_inverted_index.liposomal | 62 |
| abstract_inverted_index.potential | 181 |
| abstract_inverted_index.prevented | 128 |
| abstract_inverted_index.reticulum | 46 |
| abstract_inverted_index.signaling | 54 |
| abstract_inverted_index.treatment | 76, 120 |
| abstract_inverted_index.NOD‐like | 35 |
| abstract_inverted_index.Therefore, | 163 |
| abstract_inverted_index.activation | 142 |
| abstract_inverted_index.antagonist | 71 |
| abstract_inverted_index.apoptosis. | 162 |
| abstract_inverted_index.clinically | 202 |
| abstract_inverted_index.containing | 40 |
| abstract_inverted_index.felodipine | 72 |
| abstract_inverted_index.impairment | 169 |
| abstract_inverted_index.inhibiting | 159 |
| abstract_inverted_index.manifested | 179 |
| abstract_inverted_index.microglia, | 137 |
| abstract_inverted_index.mitophagy, | 157 |
| abstract_inverted_index.signaling, | 127 |
| abstract_inverted_index.ultrasound | 81 |
| abstract_inverted_index.Alzheimer's | 1, 74 |
| abstract_inverted_index.antioxidant | 126 |
| abstract_inverted_index.degradation | 152 |
| abstract_inverted_index.effectively | 94 |
| abstract_inverted_index.endoplasmic | 45 |
| abstract_inverted_index.felodipine. | 204 |
| abstract_inverted_index.irradiation | 103 |
| abstract_inverted_index.accumulation | 21 |
| abstract_inverted_index.ameliorated, | 177 |
| abstract_inverted_index.calreticulin | 134 |
| abstract_inverted_index.mitochondria | 155 |
| abstract_inverted_index.pathogenesis | 28 |
| abstract_inverted_index.proapoptotic | 53 |
| abstract_inverted_index.age‐related | 8 |
| abstract_inverted_index.incorporating | 67 |
| abstract_inverted_index.significantly | 176 |
| abstract_inverted_index.translocation | 131 |
| abstract_inverted_index.BBB‐crossing | 186 |
| abstract_inverted_index.anxiety‐like | 165 |
| abstract_inverted_index.felodipine@LND | 92, 189 |
| abstract_inverted_index.low‐intensity | 79 |
| abstract_inverted_index.multifunctional | 91 |
| abstract_inverted_index.(BBB)‐crossing | 87 |
| abstract_inverted_index.(felodipine@LND) | 64 |
| abstract_inverted_index.neurodegenerative | 9 |
| abstract_inverted_index.well‐recognized | 201 |
| abstract_inverted_index.irradiation‐assisted | 83 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 96 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.98458609 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |