Blood pressure and heart rate responses to orthostatic challenge and Valsalva manoeuvre in mild cognitive impairment with Lewy bodies Article Swipe
Calum A. Hamilton
,
James Frith
,
Paul C. Donaghy
,
Sally Barker
,
Rory Durcan
,
Sarah Lawley
,
Nicola Barnett
,
Michael Firbank
,
Gemma Roberts
,
John‐Paul Taylor
,
Louise Allan
,
John T. O’Brien
,
Alison J. Yarnall
,
Alan Thomas
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/gps.5709
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/gps.5709
Objectives Orthostatic hypotension is a common feature of normal ageing, and age‐related neurodegenerative diseases, in particular the synucleinopathies including dementia with Lewy bodies. Orthostatic hypotension and other abnormal cardiovascular responses may be early markers of Lewy body disease. We aimed to assess whether abnormal blood pressure and heart rate responses to orthostatic challenge and Valsalva manoeuvre would be more common in mild cognitive impairment with Lewy bodies (MCI‐LB) than MCI due to Alzheimer's disease (MCI‐AD). Methods MCI patients ( n = 89) underwent longitudinal clinical assessment with differential classification of probable MCI‐LB, possible MCI‐LB, or MCI‐AD, with objective autonomic function testing at baseline. Blood pressure and heart rate responses to active stand and Valsalva manoeuvre were calculated from beat‐to‐beat cardiovascular data, with abnormalities defined by current criteria, and age‐adjusted group differences estimated with logistic models. Results Orthostatic hypotension and abnormal heart rate response to orthostatic challenge were not more common in probable MCI‐LB than MCI‐AD. Heart rate abnormalities were likewise not more common in response to Valsalva manoeuvre in probable MCI‐LB. An abnormal blood pressure response to Valsalva (delayed return to baseline/absence of overshoot after release of strain) was more common in probable MCI‐LB than MCI‐AD. In secondary analyses, magnitude of blood pressure drop after active stand and 10‐s after release of Valsalva strain were weakly correlated with cardiac sympathetic denervation. Conclusions Probable MCI‐LB may feature abnormal blood pressure response to Valsalva, but orthostatic hypotension is not a clear distinguishing feature from MCI‐AD.
Related Topics
Concepts
Orthostatic vital signs
Valsalva maneuver
Medicine
Cardiology
Blood pressure
Heart rate
Internal medicine
Dementia with Lewy bodies
Dementia
Anesthesia
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/gps.5709
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/gps.5709
- OA Status
- hybrid
- Cited By
- 5
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4224134986
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4224134986Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/gps.5709Digital Object Identifier
- Title
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Blood pressure and heart rate responses to orthostatic challenge and Valsalva manoeuvre in mild cognitive impairment with Lewy bodiesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-04-02Full publication date if available
- Authors
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Calum A. Hamilton, James Frith, Paul C. Donaghy, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, John‐Paul Taylor, Louise Allan, John T. O’Brien, Alison J. Yarnall, Alan ThomasList of authors in order
- Landing page
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https://doi.org/10.1002/gps.5709Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/gps.5709Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/gps.5709Direct OA link when available
- Concepts
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Orthostatic vital signs, Valsalva maneuver, Medicine, Cardiology, Blood pressure, Heart rate, Internal medicine, Dementia with Lewy bodies, Dementia, Anesthesia, DiseaseTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 1, 2024: 1, 2023: 3Per-year citation counts (last 5 years)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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