Bmi‐1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone Aging Article Swipe
Jingyu Zhao
,
Ao Chen
,
Rong Wang
,
Dong Qiu
,
Haiyun Chen
,
Jiyu Li
,
Jinge Zhang
,
Tianxiao Wang
,
Yue Wang
,
Yujie Lin
,
Jiawen Zhou
,
Yifei Du
,
Hua Yuan
,
Yongjie Zhang
,
Dengshun Miao
,
Yuli Wang
,
Jianliang Jin
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202404518
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202404518
With the increase in the aging population, senile osteoporosis (SOP) has become a major global public health concern. Here, it is found that Prx1 and Bmi‐1 co‐localized in trabecular bone, bone marrow cavity, endosteum, and periosteum. Prx1 ‐driven Bmi‐1 knockout in bone‐marrow mesenchymal stem cells (BMSCs) reduced bone mass and increased bone marrow adiposity by inhibiting osteoblastic bone formation, promoting osteoclastic bone resorption, downregulating the proliferation and osteogenic differentiation of BMSCs, and upregulating the adipogenic differentiation of BMSCs. However, Prx1 ‐driven Bmi‐1 overexpression showed a contrasting phenotype to Prx1 ‐driven Bmi‐1 knockout in BMSCs. Regarding mechanism, Bmi‐1‐RING1B bound to DNMT3A and promoted its ubiquitination and inhibited DNA methylation of Runx2 at the region from 45047012 to 45047313 bp, thus promoting the osteogenic differentiation of BMSCs. Moreover, Bmi‐1‐EZH2 repressed the transcription of Cebpa by promoting H3K27 trimethylation at the promoter region −1605 to −1596 bp, thus inhibiting the adipogenic differentiation of BMSCs. It is also found that Prx1 ‐driven Bmi‐1 overexpression rescued the SOP induced by Prx1 ‐driven Bmi‐1 knockout in BMSCs. Thus, Bmi‐1 functioned as a hub protein in the epigenetic regulation of BMSCs differentiation to delay bone aging. The Prx1 ‐driven Bmi‐1 overexpression in BMSCs can be used as an approach for the translational therapy of SOP.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/advs.202404518
- OA Status
- gold
- Cited By
- 8
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402193525
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4402193525Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/advs.202404518Digital Object Identifier
- Title
-
Bmi‐1 Epigenetically Orchestrates Osteogenic and Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells to Delay Bone AgingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-09-03Full publication date if available
- Authors
-
Jingyu Zhao, Ao Chen, Rong Wang, Dong Qiu, Haiyun Chen, Jiyu Li, Jinge Zhang, Tianxiao Wang, Yue Wang, Yujie Lin, Jiawen Zhou, Yifei Du, Hua Yuan, Yongjie Zhang, Dengshun Miao, Yuli Wang, Jianliang JinList of authors in order
- Landing page
-
https://doi.org/10.1002/advs.202404518Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1002/advs.202404518Direct OA link when available
- Concepts
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Adipogenesis, RUNX2, Mesenchymal stem cell, Bone marrow, Chemistry, Cell biology, Stem cell, Endocrinology, DNA methylation, Cancer research, Internal medicine, Biology, Medicine, Transcription factor, Gene expression, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 7, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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