BMP4 micro‐immunotherapy increases collagen deposition and reduces PGE2 release in human gingival fibroblasts and increases tissue viability of engineered 3D gingiva under inflammatory conditions Article Swipe
Maria del Mar Ferrà‐Cañellas
,
Marta Munar‐Bestard
,
Laura Molina García
,
Béatrice Lejeune
,
Joana Maria Ramis
,
Marta Monjo
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/jper.20-0552
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/jper.20-0552
Background We aimed to evaluate the effect of low doses (LD) bone morphogenetic protein‐2 (BMP2) and BMP4 micro‐immunotherapy (MI) in two in vitro models of periodontal wound healing/regeneration. Methods We first evaluated the effect of LD of BMP2 and BMP4 MI on a 2D cell culture using human gingival fibroblasts (hGF) under inflammatory conditions induced by IL1β. Biocompatibility, inflammatory response (Prostaglandin E2 (PGE2) release), collagen deposition and release of extracellular matrix (ECM) organization‐related enzymes (matrix metalloproteinase‐1 (MMP1) and metalloproteinase inhibitor 1 (TIMP1)) were evaluated after short (3 days) and long‐term (24 days) treatment with BMP2 or BMP4 MI. Then, given the results obtained in the 2D cell culture, LD BMP4 MI treatment was evaluated in a 3D cell culture model of human tissue equivalent of gingiva (GTE) under the same inflammatory stimulus, evaluating the biocompatibility, inflammatory response and effect on MMP1 and TIMP1 release. Results LD BMP4 was able to decrease the release of the inflammatory mediator PGE2 and completely re‐establish the impaired collagen metabolism induced by IL1β treatment. In the 3D model, LD BMP4 treatment improved tissue viability compared with the vehicle, with similar levels to 3D tissues without inflammation. No significant effects were observed on PGE2 levels nor MMP1/TIMP1 ratio after LD BMP4 treatment, although a tendency to decrease PGE2 levels was observed after 3 days. Conclusions LD BMP4 MI treatment shows anti‐inflammatory and regenerative properties on hGF, and improved viability of 3D gingiva under inflammatory conditions. LD BMP4 MI treatment could be used on primary prevention or maintenance care of periodontitis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jper.20-0552
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/JPER.20-0552
- OA Status
- hybrid
- Cited By
- 19
- References
- 51
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3119842691Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/jper.20-0552Digital Object Identifier
- Title
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BMP4 micro‐immunotherapy increases collagen deposition and reduces PGE2 release in human gingival fibroblasts and increases tissue viability of engineered 3D gingiva under inflammatory conditionsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-03Full publication date if available
- Authors
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Maria del Mar Ferrà‐Cañellas, Marta Munar‐Bestard, Laura Molina García, Béatrice Lejeune, Joana Maria Ramis, Marta MonjoList of authors in order
- Landing page
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https://doi.org/10.1002/jper.20-0552Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/JPER.20-0552Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/JPER.20-0552Direct OA link when available
- Concepts
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TIMP1, MMP1, Matrix metalloproteinase, Viability assay, Extracellular matrix, Inflammation, Wound healing, Medicine, Chemistry, Immunology, Internal medicine, Cell, Biochemistry, Gene, Gene expressionTop concepts (fields/topics) attached by OpenAlex
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19Total citation count in OpenAlex
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2025: 4, 2024: 4, 2023: 5, 2022: 5, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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51Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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