Botanical drug preparations for alleviating hair loss in menopausal women: a global ethnopharmacological mini-review Article Swipe
Zhuo Huang
,
Wen Jie Zhao
,
Yong-Jie Gao
,
Zhi-Rong Huang
,
Qing Rui Huang
,
Sui-Zhen Cai
,
MING HUI BI
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2025.1725691
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fphar.2025.1725691
Menopause is a natural physiological transition affecting over one billion women globally. It often brings distressing symptoms, including hair loss, which impacts up to 52% of postmenopausal women due to estrogen decline, increased androgen sensitivity, and oxidative stress. Conventional treatments like minoxidil provide limited efficacy and may cause side effects, underscoring the need for accessible, culturally attuned alternatives. This mini-review explores ethnopharmacological approaches that empower women through traditional remedies targeting multi-mechanistic pathways, supported by emerging clinical data. We conducted a systematic literature search across databases (PubMed, Scopus, Web of Science), focusing on studies from 2015 to 2025 involving botanical interventions. We prioritized randomized controlled trials in vitro studies, and animal models. Key remedies include saw palmetto ( Serenoa repens ), which inhibits 5α-reductase to reduce dihydrotestosterone by approximately 30%–40%; rosemary oil ( Salvia rosmarinus Spenn.), which promotes scalp microcirculation similar to minoxidil; and ginseng ( Panax ginseng C.A.Mey.), which enhances follicle proliferation via ginsenosides. Emerging evidence from 2024 to 2025 reviews highlights multi-target mechanisms in plant extracts, including phytoestrogenic and anti-inflammatory effects. Nutraceuticals have demonstrated improved hair density in menopausal cohorts. These low-cost, community-rooted therapies foster women’s autonomy and cultural resilience. This mini-review is not comprehensive; it highlights key challenges in current research, such as limited menopausal-specific evidence and standardization gaps. It advocates for future priorities like interdisciplinary trials integrating ethnobotany with modern pharmacology to bridge global health disparities. This aligns with the special issue’s vision of empowering women through sustainable, nature-based solutions.
Related Topics
Concepts
Medicine
Traditional medicine
Black cohosh
Clinical trial
Hair loss
Nutraceutical
Alternative medicine
Minoxidil
Pharmacology
Ginseng
Menopause
Alopecia areata
Randomized controlled trial
Systematic review
Drug
Ethnobotany
Estrogen
Hot flash
Bioinformatics
Health benefits
Hair growth
Pill
Review article
Drug development
Skin Aging
Androgen
Medicinal plants
Metadata
- Type
- article
- Landing Page
- https://doi.org/10.3389/fphar.2025.1725691
- https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1725691/pdf
- OA Status
- gold
- References
- 74
- OpenAlex ID
- https://openalex.org/W7106680989
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W7106680989Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fphar.2025.1725691Digital Object Identifier
- Title
-
Botanical drug preparations for alleviating hair loss in menopausal women: a global ethnopharmacological mini-reviewWork title
- Type
-
articleOpenAlex work type
- Publication year
-
2025Year of publication
- Publication date
-
2025-11-26Full publication date if available
- Authors
-
Zhuo Huang, Wen Jie Zhao, Yong-Jie Gao, Zhi-Rong Huang, Qing Rui Huang, Sui-Zhen Cai, MING HUI BIList of authors in order
- Landing page
-
https://doi.org/10.3389/fphar.2025.1725691Publisher landing page
- PDF URL
-
https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1725691/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://public-pages-files-2025.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1725691/pdfDirect OA link when available
- Concepts
-
Medicine, Traditional medicine, Black cohosh, Clinical trial, Hair loss, Nutraceutical, Alternative medicine, Minoxidil, Pharmacology, Ginseng, Menopause, Alopecia areata, Randomized controlled trial, Systematic review, Drug, Ethnobotany, Estrogen, Hot flash, Bioinformatics, Health benefits, Hair growth, Pill, Review article, Drug development, Skin Aging, Androgen, Medicinal plantsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
74Number of works referenced by this work
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| abstract_inverted_index.a | 2, 79 |
| abstract_inverted_index.), | 119 |
| abstract_inverted_index.It | 12, 211 |
| abstract_inverted_index.We | 77, 100 |
| abstract_inverted_index.as | 204 |
| abstract_inverted_index.by | 73, 126 |
| abstract_inverted_index.in | 105, 164, 178, 200 |
| abstract_inverted_index.is | 1, 193 |
| abstract_inverted_index.it | 196 |
| abstract_inverted_index.of | 25, 88, 236 |
| abstract_inverted_index.on | 91 |
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| abstract_inverted_index.up | 22 |
| abstract_inverted_index.52% | 24 |
| abstract_inverted_index.Key | 111 |
| abstract_inverted_index.Web | 87 |
| abstract_inverted_index.and | 35, 45, 108, 142, 169, 188, 208 |
| abstract_inverted_index.due | 28 |
| abstract_inverted_index.for | 53, 213 |
| abstract_inverted_index.key | 198 |
| abstract_inverted_index.may | 46 |
| abstract_inverted_index.not | 194 |
| abstract_inverted_index.oil | 130 |
| abstract_inverted_index.one | 8 |
| abstract_inverted_index.saw | 114 |
| abstract_inverted_index.the | 51, 232 |
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| abstract_inverted_index.2015 | 94 |
| abstract_inverted_index.2024 | 157 |
| abstract_inverted_index.2025 | 96, 159 |
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| abstract_inverted_index.hair | 18, 176 |
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| abstract_inverted_index.like | 40, 216 |
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| abstract_inverted_index.such | 203 |
| abstract_inverted_index.that | 63 |
| abstract_inverted_index.with | 221, 231 |
| abstract_inverted_index.Panax | 145 |
| abstract_inverted_index.These | 181 |
| abstract_inverted_index.cause | 47 |
| abstract_inverted_index.data. | 76 |
| abstract_inverted_index.gaps. | 210 |
| abstract_inverted_index.loss, | 19 |
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| abstract_inverted_index.plant | 165 |
| abstract_inverted_index.scalp | 137 |
| abstract_inverted_index.vitro | 106 |
| abstract_inverted_index.which | 20, 120, 135, 148 |
| abstract_inverted_index.women | 10, 27, 65, 238 |
| abstract_inverted_index.Salvia | 132 |
| abstract_inverted_index.across | 83 |
| abstract_inverted_index.aligns | 230 |
| abstract_inverted_index.animal | 109 |
| abstract_inverted_index.bridge | 225 |
| abstract_inverted_index.brings | 14 |
| abstract_inverted_index.foster | 185 |
| abstract_inverted_index.future | 214 |
| abstract_inverted_index.global | 226 |
| abstract_inverted_index.health | 227 |
| abstract_inverted_index.modern | 222 |
| abstract_inverted_index.reduce | 124 |
| abstract_inverted_index.repens | 118 |
| abstract_inverted_index.search | 82 |
| abstract_inverted_index.trials | 104, 218 |
| abstract_inverted_index.vision | 235 |
| abstract_inverted_index.Scopus, | 86 |
| abstract_inverted_index.Serenoa | 117 |
| abstract_inverted_index.attuned | 56 |
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| abstract_inverted_index.current | 201 |
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| abstract_inverted_index.ginseng | 143, 146 |
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| abstract_inverted_index.special | 233 |
| abstract_inverted_index.stress. | 37 |
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| abstract_inverted_index.through | 66, 239 |
| abstract_inverted_index.(PubMed, | 85 |
| abstract_inverted_index.Emerging | 154 |
| abstract_inverted_index.Spenn.), | 134 |
| abstract_inverted_index.androgen | 33 |
| abstract_inverted_index.autonomy | 187 |
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| abstract_inverted_index.cohorts. | 180 |
| abstract_inverted_index.cultural | 189 |
| abstract_inverted_index.decline, | 31 |
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| abstract_inverted_index.effects. | 171 |
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| abstract_inverted_index.evidence | 155, 207 |
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| abstract_inverted_index.focusing | 90 |
| abstract_inverted_index.follicle | 150 |
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| abstract_inverted_index.studies, | 107 |
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| abstract_inverted_index.Science), | 89 |
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| abstract_inverted_index.including | 17, 167 |
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| abstract_inverted_index.issue’s | 234 |
| abstract_inverted_index.low-cost, | 182 |
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| abstract_inverted_index.30%–40%; | 128 |
| abstract_inverted_index.C.A.Mey.), | 147 |
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| abstract_inverted_index.mini-review | 59, 192 |
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| abstract_inverted_index.resilience. | 190 |
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