BRAF Mutation in Neuroblastoma: A Case Report of a Rare Finding Article Swipe

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Neuroblastoma Medicine Stage (stratigraphy) Melanoma Rare disease Mutation Solid tumor Cancer research Disease Oncology Pathology Internal medicine Cancer Biology Genetics Gene Paleontology Cell culture

Sara C. Hutchins , Sara Ferguson R , Geling Li , Elizabeth A. Beierle , Elizabeth Alva ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.22541/au.165839790.04919195/v1 · OA: W4286016546

Neuroblastoma is the most common extracranial solid tumor in children. Approximately half of the patients with Stage MS disease have tumor regression, but 10-15% will have progression of disease. BRAF mutations are common in some cancers, such as melanoma and pediatric astrocytoma, but are rare in pediatric extracranial solid tumors, including neuroblastoma. Here we report the case of an infant with Stage MS neuroblastoma with a rare BRAF V600E mutation and subsequent progression to Stage M disease.