Brain Morphometry and Cognitive Features in the Prediction of Irritable Bowel Syndrome Article Swipe
Arvid Lundervold
,
Ben René Bjørsvik
,
Julie Billing
,
Birgitte Berentsen
,
Gülen Arslan Lied
,
Elisabeth Kjelsvik Steinsvik
,
Trygve Hausken
,
Daniela M. Pfabigan
,
Astri J. Lundervold
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics15040470
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics15040470
Background/Objectives: Irritable bowel syndrome (IBS) is a gut–brain disorder characterized by abdominal pain, altered bowel habits, and psychological distress. While brain–gut interactions are recognized in IBS pathophysiology, the relationship between brain morphometry, cognitive function, and clinical features remains poorly understood. The study aims to conduct the following: (i) to replicate previous univariate morphometric findings in IBS patients and conduct software comparisons; (ii) to investigate whether multivariate analysis of brain morphometric measures and cognitive performance can distinguish IBS patients from healthy controls (HCs), and evaluate the importance of structural and cognitive features in this discrimination. Methods: We studied 49 IBS patients and 29 HCs using structural brain magnetic resonance images (MRIs) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Brain morphometry was analyzed using FreeSurfer v6.0.1 and v7.4.1, with IBS severity assessed via the IBS-Severity Scoring System. We employed univariate, multivariate, and machine learning approaches with cross-validation. Results: The FreeSurfer version comparison revealed substantial variations in morphometric measurements, while morphometric measures alone showed limited discrimination between groups; combining morphometric and cognitive measures achieved 93% sensitivity in identifying IBS patients (22% specificity). The feature importance analysis highlighted the role of subcortical structures (the hippocampus, caudate, and putamen) and cognitive domains (recall and verbal skills) in group discrimination. Conclusions: Our comprehensive open-source framework suggests that combining brain morphometry and cognitive measures improves IBS-HC discrimination compared to morphometric measures alone. The importance of subcortical structures and specific cognitive domains supports complex brain–gut interaction in IBS, emphasizing the need for multimodal approaches and rigorous methodological considerations.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/diagnostics15040470
- OA Status
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- References
- 67
- Related Works
- 10
- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4407565487Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/diagnostics15040470Digital Object Identifier
- Title
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Brain Morphometry and Cognitive Features in the Prediction of Irritable Bowel SyndromeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-02-14Full publication date if available
- Authors
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Arvid Lundervold, Ben René Bjørsvik, Julie Billing, Birgitte Berentsen, Gülen Arslan Lied, Elisabeth Kjelsvik Steinsvik, Trygve Hausken, Daniela M. Pfabigan, Astri J. LundervoldList of authors in order
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https://doi.org/10.3390/diagnostics15040470Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.3390/diagnostics15040470Direct OA link when available
- Concepts
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Irritable bowel syndrome, Cognition, Brain morphometry, Voxel-based morphometry, Medicine, Psychology, Neuroscience, Clinical psychology, Internal medicine, Radiology, Magnetic resonance imaging, White matterTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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