Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis root Article Swipe
Trevor M. Nolan
,
Nemanja Vukašinović
,
Che‐Wei Hsu
,
Jingyuan Zhang
,
Isabelle Vanhoutte
,
Rachel Shahan
,
Isaiah Taylor
,
Laura Greenstreet
,
Matthieu Heitz
,
Anton Afanassiev
,
Ping Wang
,
Pablo Székely
,
Aiden Brosnan
,
Yanhai Yin
,
Geoffrey Schiebinger
,
Uwe Ohler
,
Eugenia Russinova
,
Philip N. Benfey
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1126/science.adf4721
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1126/science.adf4721
Brassinosteroids are plant steroid hormones that regulate diverse processes, such as cell division and cell elongation, through gene regulatory networks that vary in space and time. By using time series single-cell RNA sequencing to profile brassinosteroid-responsive gene expression specific to different cell types and developmental stages of the Arabidopsis root, we identified the elongating cortex as a site where brassinosteroids trigger a shift from proliferation to elongation associated with increased expression of cell wall–related genes. Our analysis revealed HOMEOBOX FROM ARABIDOPSIS THALIANA 7 ( HAT7 ) and GT-2-LIKE 1 ( GTL1 ) as brassinosteroid-responsive transcription factors that regulate cortex cell elongation. These results establish the cortex as a site of brassinosteroid-mediated growth and unveil a brassinosteroid signaling network regulating the transition from proliferation to elongation, which illuminates aspects of spatiotemporal hormone responses.
Related Topics
Concepts
Brassinosteroid
Arabidopsis
Biology
Cell biology
Arabidopsis thaliana
Cell division
Transcription factor
Gene expression
Lateral root
Gene
Genetics
Cell
Mutant
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1126/science.adf4721
- OA Status
- green
- Cited By
- 130
- References
- 130
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4362507269
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4362507269Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1126/science.adf4721Digital Object Identifier
- Title
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Brassinosteroid gene regulatory networks at cellular resolution in the Arabidopsis rootWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-03-31Full publication date if available
- Authors
-
Trevor M. Nolan, Nemanja Vukašinović, Che‐Wei Hsu, Jingyuan Zhang, Isabelle Vanhoutte, Rachel Shahan, Isaiah Taylor, Laura Greenstreet, Matthieu Heitz, Anton Afanassiev, Ping Wang, Pablo Székely, Aiden Brosnan, Yanhai Yin, Geoffrey Schiebinger, Uwe Ohler, Eugenia Russinova, Philip N. BenfeyList of authors in order
- Landing page
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https://doi.org/10.1126/science.adf4721Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10119888/pdf/nihms-1889089.pdfDirect OA link when available
- Concepts
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Brassinosteroid, Arabidopsis, Biology, Cell biology, Arabidopsis thaliana, Cell division, Transcription factor, Gene expression, Lateral root, Gene, Genetics, Cell, MutantTop concepts (fields/topics) attached by OpenAlex
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130Total citation count in OpenAlex
- Citations by year (recent)
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2025: 56, 2024: 45, 2023: 29Per-year citation counts (last 5 years)
- References (count)
-
130Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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