Jornal Brasileiro de Pneumologia • Vol 49 • No 2
Brazilian guidelines for the pharmacological treatment of the pulmonary symptoms of cystic fibrosis. Official document of the Sociedade Brasileira de Pneumologia e Tisiologia (SBPT, Brazilian Thoracic Association)
May 2023 • Rodrigo Abensur Athanazio, Suzana Érico Tanni, Juliana Carvalho Ferreira, Paulo de Tarso Roth Dalcin, Marcelo Bicalho de Fuccio, Concetta Esposito, M…
Cystic fibrosis (CF) is a genetic disease that results in dysfunction of the CF transmembrane conductance regulator (CFTR) protein, which is a chloride and bicarbonate channel expressed in the apical portion of epithelial cells of various organs. Dysfunction of that protein results in diverse clinical manifestations, primarily involving the respiratory and gastrointestinal systems, impairing quality of life and reducing life expectancy. Although CF is still an incurable pathology, the therapeutic and prognostic pe…