Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal Contraception Article Swipe
Jennifer E. Balkus
,
Thesla Palanee‐Phillips
,
Krishnaveni Reddy
,
Samantha Siva
,
Ishana Harkoo
,
Clemensia Nakabiito
,
Kenneth Kintu
,
Gonasangrie Nair
,
Catherine A. Chappell
,
Flavia Matovu Kiweewa
,
Samuel Kabwigu
,
Logashvari Naidoo
,
Nitesha Jeenarain
,
Mark A. Marzinke
,
Lydia Soto‐Torres
,
Elizabeth R. Brown
,
Jared M. Baeten
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1097/qai.0000000000001455
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1097/qai.0000000000001455
Objective: To evaluate the potential for a clinically relevant drug–drug interaction with concomitant use of a dapivirine vaginal ring, a novel antiretroviral-based HIV-1 prevention strategy, and hormonal contraception by examining contraceptive efficacies with and without dapivirine ring use. Design: A secondary analysis of women participating in MTN-020/ASPIRE, a randomized, double-blind, placebo-controlled trial of the dapivirine vaginal ring for HIV-1 prevention. Methods: Use of a highly effective method of contraception was an eligibility criterion for study participation. Urine pregnancy tests were performed monthly. Pregnancy incidence by arm was calculated separately for each hormonal contraceptive method and compared using an Andersen–Gill proportional hazards model stratified by site and censored at HIV-1 infection. Results: Of 2629 women enrolled, 2310 women returned for follow-up and reported using a hormonal contraceptive method at any point during study participation (1139 in the dapivirine arm and 1171 in the placebo arm). Pregnancy incidence in the dapivirine arm versus placebo among women using injectable depot medroxyprogesterone acetate was 0.43% vs. 0.54%, among women using injectable norethisterone enanthate was 1.15% vs. 0%, among women using hormonal implants was 0.22% vs. 0.69%, and among women using oral contraceptive pills was 32.26% vs. 28.01%. Pregnancy incidence did not differ by study arm for any of the hormonal contraceptive methods. Conclusions: Use of the dapivirine ring does not reduce the effectiveness of hormonal contraceptives for pregnancy prevention. Oral contraceptive pill use was associated with high pregnancy incidence, potentially because of poor pill adherence. Injectable and implantable methods were highly effective in preventing pregnancy.
Related Topics
Concepts
Vaginal ring
Medicine
Hormonal contraception
Obstetrics
Pregnancy
Gynecology
Medroxyprogesterone acetate
Desogestrel
Population
Placebo
Ethinylestradiol
Pill
Family planning
Hormone
Internal medicine
Pharmacology
Research methodology
Environmental health
Biology
Genetics
Pathology
Alternative medicine
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/qai.0000000000001455
- OA Status
- green
- Cited By
- 18
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2619918398
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2619918398Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/qai.0000000000001455Digital Object Identifier
- Title
-
Brief Report: Dapivirine Vaginal Ring Use Does Not Diminish the Effectiveness of Hormonal ContraceptionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-05-25Full publication date if available
- Authors
-
Jennifer E. Balkus, Thesla Palanee‐Phillips, Krishnaveni Reddy, Samantha Siva, Ishana Harkoo, Clemensia Nakabiito, Kenneth Kintu, Gonasangrie Nair, Catherine A. Chappell, Flavia Matovu Kiweewa, Samuel Kabwigu, Logashvari Naidoo, Nitesha Jeenarain, Mark A. Marzinke, Lydia Soto‐Torres, Elizabeth R. Brown, Jared M. BaetenList of authors in order
- Landing page
-
https://doi.org/10.1097/qai.0000000000001455Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/5597463Direct OA link when available
- Concepts
-
Vaginal ring, Medicine, Hormonal contraception, Obstetrics, Pregnancy, Gynecology, Medroxyprogesterone acetate, Desogestrel, Population, Placebo, Ethinylestradiol, Pill, Family planning, Hormone, Internal medicine, Pharmacology, Research methodology, Environmental health, Biology, Genetics, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
18Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3, 2023: 2, 2022: 1, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
25Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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