Broad Tuning of Paper Microfluidic Properties by Covalent Surface Modification for Precise Flow Control and Sensing Article Swipe
Canan Aksoy
,
Ischa van Kesteren
,
Han Zuilhof
,
Gert IJ. Salentijn
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acsabm.4c01812
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1021/acsabm.4c01812
In an effort to innovate on-site sensing platforms for a wide range of analytes in different matrices, microfluidic paper-based devices (μPADs) are promising candidates to bring the lab to the sample, as they allow passive, capillary-action-driven flow. Their use, however, is somewhat limited by the fact that the integration of advanced functionality and flow control is difficult. Although recent progress in this area has led to the development of on/off-valving and timing control of flow by changing the chemical and physical properties of paper, precise control over flow in paper microfluidics remains challenging. Here, we propose the use of a simple covalent modification of cellulose paper to tune its surface properties, thereby introducing a broad range of functionality and applicability. For this purpose, fatty acyl chlorides with different chain lengths were used as hydrophobic reagents to change the surface properties. The modified paper was characterized by FTIR-ATR, static water contact angle measurements, and capillary flow properties (permeability, maximum flow distance, and flow rate). The produced papers were then applied in several proof-of-concept devices to demonstrate their potential in sensing and actuating for improved on-site analysis. We demonstrate how precisely modified paper can be used for surface tension measurements and multistep valving based on its wickability for solutions of varying surface tensions, for the determination of ethanol concentration in water by monitoring the maximum flow distance in a 3D-printed device, and for the optimization of on-paper liquid-liquid extraction via fine-tuned control of capillary flow rates.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acsabm.4c01812
- OA Status
- hybrid
- Cited By
- 1
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409550948
All OpenAlex metadata
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https://openalex.org/W4409550948Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acsabm.4c01812Digital Object Identifier
- Title
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Broad Tuning of Paper Microfluidic Properties by Covalent Surface Modification for Precise Flow Control and SensingWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
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2025-04-17Full publication date if available
- Authors
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Canan Aksoy, Ischa van Kesteren, Han Zuilhof, Gert IJ. SalentijnList of authors in order
- Landing page
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https://doi.org/10.1021/acsabm.4c01812Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1021/acsabm.4c01812Direct OA link when available
- Concepts
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Microfluidics, Surface modification, Nanotechnology, Materials science, Flow (mathematics), Flow control (data), Computer science, Engineering, Chemical engineering, Mechanics, Physics, TelecommunicationsTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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48Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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