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Brown-fat-mediated tumour suppression by cold-altered global metabolism
August 2022 • Takahiro Seki, Yunlong Yang, Xiaoting Sun, Sharon Lim, Sisi Xie, Ziheng Guo, Wenjing Xiong, Masashi Kuroda, Hiroshi Sakaue, Kayoko Hosaka, Jing Xu, M…
Abstract Glucose uptake is essential for cancer glycolysis and is involved in non-shivering thermogenesis of adipose tissues 1–6 . Most cancers use glycolysis to harness energy for their infinite growth, invasion and metastasis 2,7,8 . Activation of thermogenic metabolism in brown adipose tissue (BAT) by cold and drugs instigates blood glucose uptake in adipocytes 4,5,9 . However, the functional effects of the global metabolic changes associated with BAT activation on tumour growth are unclear. Here we show that e…
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