Bubble and macroaggregate methods differ in detection of blood flow through intrapulmonary arteriovenous anastomoses in upright and supine hypoxia in humans Article Swipe
Joseph W. Duke
,
Jonathan E. Elliott
,
Steven S. Laurie
,
Thomas Voelkel
,
Igor M. Gladstone
,
Mathews B. Fish
,
Andrew T. Lovering
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1152/japplphysiol.00673.2017
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1152/japplphysiol.00673.2017
Blood flow through intrapulmonary arteriovenous anastomoses (Q̇ IPAVA ) increases in healthy humans breathing hypoxic gas and is potentially dependent on body position. Previous work in subjects breathing room air has shown an effect of body position when Q̇ IPAVA is detected with transthoracic saline contrast echocardiography (TTSCE). However, the potential effect of body position on Q̇ IPAVA has not been investigated when subjects are breathing hypoxic gas or with a technique capable of quantifying Q̇ IPAVA . Thus the purpose of this study was to quantify the effect of body position on Q̇ IPAVA when breathing normoxic and hypoxic gas at rest. We studied Q̇ IPAVA with TTSCE and quantified Q̇ IPAVA with filtered technetium-99m-labeled macroaggregates of albumin ( 99m Tc-MAA) in seven healthy men breathing normoxic and hypoxic (12% O 2 ) gas at rest while supine and upright. On the basis of previous work using TTSCE, we hypothesized that the quantified Q̇ IPAVA would be greatest with hypoxia in the supine position. We found that Q̇ IPAVA quantified with 99m Tc-MAA significantly increased while subjects breathed hypoxic gas in both supine and upright body positions (ΔQ̇ IPAVA = 0.7 ± 0.4 vs. 2.5 ± 1.1% of cardiac output, respectively). Q̇ IPAVA detected with TTSCE increased from normoxia in supine hypoxia but not in upright hypoxia (median hypoxia bubble score of 2 vs. 0, respectively). Surprisingly, Q̇ IPAVA magnitude was greatest in upright hypoxia, when Q̇ IPAVA was undetectable with TTSCE. These findings suggest that the relationship between TTSCE and 99m Tc-MAA is more complex than previously appreciated, perhaps because of the different physical properties of bubbles and MAA in solution. NEW & NOTEWORTHY Using saline contrast bubbles and radiolabeled macroaggregrates (MAA), we detected and quantified, respectively, hypoxia-induced blood flow through intrapulmonary arteriovenous anastomoses (Q̇ IPAVA ) in supine and upright body positions in healthy men. Upright hypoxia resulted in the largest magnitude of Q̇ IPAVA quantified with MAA but the lowest Q̇ IPAVA detected with saline contrast bubbles. These surprising results suggest that the differences in physical properties between saline contrast bubbles and MAA in blood may affect their behavior in vivo.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1152/japplphysiol.00673.2017
- https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00673.2017
- OA Status
- bronze
- Cited By
- 7
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2757823507
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2757823507Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1152/japplphysiol.00673.2017Digital Object Identifier
- Title
-
Bubble and macroaggregate methods differ in detection of blood flow through intrapulmonary arteriovenous anastomoses in upright and supine hypoxia in humansWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-10-02Full publication date if available
- Authors
-
Joseph W. Duke, Jonathan E. Elliott, Steven S. Laurie, Thomas Voelkel, Igor M. Gladstone, Mathews B. Fish, Andrew T. LoveringList of authors in order
- Landing page
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https://doi.org/10.1152/japplphysiol.00673.2017Publisher landing page
- PDF URL
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https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00673.2017Direct link to full text PDF
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YesWhether a free full text is available
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-
bronzeOpen access status per OpenAlex
- OA URL
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https://journals.physiology.org/doi/pdf/10.1152/japplphysiol.00673.2017Direct OA link when available
- Concepts
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Supine position, Arteriovenous Anastomosis, Hypoxia (environmental), Blood flow, Medicine, Anastomosis, Anesthesia, Cardiology, Internal medicine, Surgery, Chemistry, Oxygen, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
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2023: 2, 2022: 1, 2021: 1, 2019: 1, 2018: 2Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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