Bufotalin-Loaded Biomimetic Prussian Blue Nanoparticles For Colorectal Cancer Chemo-Photothermal Ferroptosis Therapy Article Swipe

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Prussian blue Photothermal therapy In vivo Colorectal cancer Hyperthermia Nanoparticle In vitro Cancer research Photothermal effect Materials science Biocompatible material Chemistry Nanotechnology Cancer Biophysics Biomedical engineering Medicine Biochemistry Internal medicine Electrochemistry Biology Physical chemistry Electrode Biotechnology

Yi Wu , Jiahui Tian , Jialu Yang , Qian Peng , Zhengchun Wu , Rushi Liu , Mengjie Luo , Yilan Qiu , Ruiyun Cao ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.2217/nnm-2023-0293 · OA: W4390696036

Purpose: We constructed biomimetic nanoparticles with biocompatible, tumor-targeting, laser-responsive properties for ferroptosis-induced colorectal cancer chemo-photothermal therapy, with the aim to realize double-hit ferroptosis treatment for colorectal cancer. Methods: The nanoparticles were prepared by first loading the chemotherapy drug bufotalin (CS-5) with Prussian blue (PB), then combining a hybridized erythrocyte-tumor membrane (M) with PB@CS-5 to produce PB@CS-5@M. The chemo-photothermal therapy efficiency of PB@CS-5@M was tested by in vitro and in vivo experiments. Results and conclusion: The combined PB and CS-5 act as promising ferroptosis inducers to enhance ferroptosis efficacy. The hyperthermia induced by laser stimulation can trigger PB to release CS-5 and iron and ferrous ions, which further promotes ferroptosis.