C-KIT Expression in Orbital Cavernous Venous Hemangiomas Article Swipe
Mizhir Atallah
,
Natalia Edison
,
E. Levi
,
Irit Elmalah
,
Daniel Briscoe
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biom11081199
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/biom11081199
Orbital (slow flow) cavernous venous hemangiomas (OCVH) are the most common benign orbital tumors in adults. The c-KIT is a tyrosine kinase receptor, which is expressed on several types of cells, is thought to play a key role in tumor pathogenesis. The purpose of this study was to evaluate the presence of the receptor c-KIT in OCVH. Our retrospective study examined 16 orbital cavernous venous hemangiomas from 16 cases operated on between 2006–2016 at Emek Medical Center. The mean tumor size was 18.4 mm. Symptoms appeared between 6 months and 22 years before operation. All specimens were analyzed for the c-KIT receptor through immunohistochemistry. The c-KIT was expressed by the endothelium in all 16 preparates. Staining was strong in two cases, moderate in six, and weak in eight cases, with no statistically significant correlation between staining and tumor size (p = 0.69) or the symptom duration (p = 0.15). We conclude that c-KIT may play an important role in the pathogenesis of OCVH. This pilot study is significant in that tumor-targeted therapy such as Imatinib Mesylate and Sunitinib may have a role in treating surgically complicated cases located in the orbital apex. A large multicenter collaborative study is necessary to examine the role of c-KIT in OCVH.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biom11081199
- https://www.mdpi.com/2218-273X/11/8/1199/pdf?version=1628836713
- OA Status
- gold
- Cited By
- 3
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3189316318
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3189316318Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/biom11081199Digital Object Identifier
- Title
-
C-KIT Expression in Orbital Cavernous Venous HemangiomasWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-08-12Full publication date if available
- Authors
-
Mizhir Atallah, Natalia Edison, E. Levi, Irit Elmalah, Daniel BriscoeList of authors in order
- Landing page
-
https://doi.org/10.3390/biom11081199Publisher landing page
- PDF URL
-
https://www.mdpi.com/2218-273X/11/8/1199/pdf?version=1628836713Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2218-273X/11/8/1199/pdf?version=1628836713Direct OA link when available
- Concepts
-
Pathogenesis, Immunohistochemistry, Medicine, Hemangioma, Imatinib mesylate, Pathology, Cavernous hemangiomas, Sunitinib, Vein, Internal medicine, Imatinib, Cancer, Myeloid leukemiaTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
3Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3189316318 |
|---|---|
| doi | https://doi.org/10.3390/biom11081199 |
| ids.doi | https://doi.org/10.3390/biom11081199 |
| ids.mag | 3189316318 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34439864 |
| ids.openalex | https://openalex.org/W3189316318 |
| fwci | 0.7627908 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000293 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Adolescent |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000328 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Adult |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000368 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Aged |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D002648 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Child |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D005260 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Female |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D015972 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Gene Expression Regulation, Neoplastic |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D006392 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | Hemangioma, Cavernous |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D006392 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Hemangioma, Cavernous |
| mesh[8].qualifier_ui | Q000473 |
| mesh[8].descriptor_ui | D006392 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | pathology |
| mesh[8].descriptor_name | Hemangioma, Cavernous |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D006801 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Humans |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D008297 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Male |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008875 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Middle Aged |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D009918 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Orbital Neoplasms |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D009918 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | Orbital Neoplasms |
| mesh[14].qualifier_ui | Q000473 |
| mesh[14].descriptor_ui | D009918 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | pathology |
| mesh[14].descriptor_name | Orbital Neoplasms |
| mesh[15].qualifier_ui | Q000096 |
| mesh[15].descriptor_ui | D019009 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | biosynthesis |
| mesh[15].descriptor_name | Proto-Oncogene Proteins c-kit |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D019009 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | Proto-Oncogene Proteins c-kit |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D055815 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Young Adult |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000293 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Adolescent |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D000328 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Adult |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D000368 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Aged |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D002648 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Child |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D005260 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Female |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D015972 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Gene Expression Regulation, Neoplastic |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D006392 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | Hemangioma, Cavernous |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D006392 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Hemangioma, Cavernous |
| mesh[26].qualifier_ui | Q000473 |
| mesh[26].descriptor_ui | D006392 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | pathology |
| mesh[26].descriptor_name | Hemangioma, Cavernous |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D006801 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Humans |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D008297 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Male |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D008875 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Middle Aged |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D009918 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | Orbital Neoplasms |
| mesh[31].qualifier_ui | Q000378 |
| mesh[31].descriptor_ui | D009918 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | metabolism |
| mesh[31].descriptor_name | Orbital Neoplasms |
| mesh[32].qualifier_ui | Q000473 |
| mesh[32].descriptor_ui | D009918 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | pathology |
| mesh[32].descriptor_name | Orbital Neoplasms |
| mesh[33].qualifier_ui | Q000096 |
| mesh[33].descriptor_ui | D019009 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | biosynthesis |
| mesh[33].descriptor_name | Proto-Oncogene Proteins c-kit |
| mesh[34].qualifier_ui | Q000235 |
| mesh[34].descriptor_ui | D019009 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | genetics |
| mesh[34].descriptor_name | Proto-Oncogene Proteins c-kit |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D055815 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Young Adult |
| type | article |
| title | C-KIT Expression in Orbital Cavernous Venous Hemangiomas |
| biblio.issue | 8 |
| biblio.volume | 11 |
| biblio.last_page | 1199 |
| biblio.first_page | 1199 |
| topics[0].id | https://openalex.org/T10980 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2746 |
| topics[0].subfield.display_name | Surgery |
| topics[0].display_name | Vascular Malformations and Hemangiomas |
| topics[1].id | https://openalex.org/T12278 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9993000030517578 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2730 |
| topics[1].subfield.display_name | Oncology |
| topics[1].display_name | Vascular Tumors and Angiosarcomas |
| topics[2].id | https://openalex.org/T13363 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9966999888420105 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2734 |
| topics[2].subfield.display_name | Pathology and Forensic Medicine |
| topics[2].display_name | Soft tissue tumors and treatment |
| is_xpac | False |
| apc_list.value | 2100 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2273 |
| apc_paid.value | 2100 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2273 |
| concepts[0].id | https://openalex.org/C2780942790 |
| concepts[0].level | 2 |
| concepts[0].score | 0.673067033290863 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q372016 |
| concepts[0].display_name | Pathogenesis |
| concepts[1].id | https://openalex.org/C204232928 |
| concepts[1].level | 2 |
| concepts[1].score | 0.6129103302955627 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q899285 |
| concepts[1].display_name | Immunohistochemistry |
| concepts[2].id | https://openalex.org/C71924100 |
| concepts[2].level | 0 |
| concepts[2].score | 0.5747353434562683 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[2].display_name | Medicine |
| concepts[3].id | https://openalex.org/C2780191036 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5548077821731567 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q861028 |
| concepts[3].display_name | Hemangioma |
| concepts[4].id | https://openalex.org/C3019892230 |
| concepts[4].level | 4 |
| concepts[4].score | 0.541100263595581 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q177094 |
| concepts[4].display_name | Imatinib mesylate |
| concepts[5].id | https://openalex.org/C142724271 |
| concepts[5].level | 1 |
| concepts[5].score | 0.45756298303604126 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[5].display_name | Pathology |
| concepts[6].id | https://openalex.org/C2911163174 |
| concepts[6].level | 3 |
| concepts[6].score | 0.45310139656066895 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1737261 |
| concepts[6].display_name | Cavernous hemangiomas |
| concepts[7].id | https://openalex.org/C2779490328 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4392838478088379 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q417542 |
| concepts[7].display_name | Sunitinib |
| concepts[8].id | https://openalex.org/C2777202286 |
| concepts[8].level | 2 |
| concepts[8].score | 0.42577823996543884 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q9609 |
| concepts[8].display_name | Vein |
| concepts[9].id | https://openalex.org/C126322002 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3194308876991272 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[9].display_name | Internal medicine |
| concepts[10].id | https://openalex.org/C2777583451 |
| concepts[10].level | 3 |
| concepts[10].score | 0.17244413495063782 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q177094 |
| concepts[10].display_name | Imatinib |
| concepts[11].id | https://openalex.org/C121608353 |
| concepts[11].level | 2 |
| concepts[11].score | 0.14317145943641663 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[11].display_name | Cancer |
| concepts[12].id | https://openalex.org/C2778729363 |
| concepts[12].level | 2 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11688946 |
| concepts[12].display_name | Myeloid leukemia |
| keywords[0].id | https://openalex.org/keywords/pathogenesis |
| keywords[0].score | 0.673067033290863 |
| keywords[0].display_name | Pathogenesis |
| keywords[1].id | https://openalex.org/keywords/immunohistochemistry |
| keywords[1].score | 0.6129103302955627 |
| keywords[1].display_name | Immunohistochemistry |
| keywords[2].id | https://openalex.org/keywords/medicine |
| keywords[2].score | 0.5747353434562683 |
| keywords[2].display_name | Medicine |
| keywords[3].id | https://openalex.org/keywords/hemangioma |
| keywords[3].score | 0.5548077821731567 |
| keywords[3].display_name | Hemangioma |
| keywords[4].id | https://openalex.org/keywords/imatinib-mesylate |
| keywords[4].score | 0.541100263595581 |
| keywords[4].display_name | Imatinib mesylate |
| keywords[5].id | https://openalex.org/keywords/pathology |
| keywords[5].score | 0.45756298303604126 |
| keywords[5].display_name | Pathology |
| keywords[6].id | https://openalex.org/keywords/cavernous-hemangiomas |
| keywords[6].score | 0.45310139656066895 |
| keywords[6].display_name | Cavernous hemangiomas |
| keywords[7].id | https://openalex.org/keywords/sunitinib |
| keywords[7].score | 0.4392838478088379 |
| keywords[7].display_name | Sunitinib |
| keywords[8].id | https://openalex.org/keywords/vein |
| keywords[8].score | 0.42577823996543884 |
| keywords[8].display_name | Vein |
| keywords[9].id | https://openalex.org/keywords/internal-medicine |
| keywords[9].score | 0.3194308876991272 |
| keywords[9].display_name | Internal medicine |
| keywords[10].id | https://openalex.org/keywords/imatinib |
| keywords[10].score | 0.17244413495063782 |
| keywords[10].display_name | Imatinib |
| keywords[11].id | https://openalex.org/keywords/cancer |
| keywords[11].score | 0.14317145943641663 |
| keywords[11].display_name | Cancer |
| language | en |
| locations[0].id | doi:10.3390/biom11081199 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210236520 |
| locations[0].source.issn | 2218-273X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2218-273X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Biomolecules |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/2218-273X/11/8/1199/pdf?version=1628836713 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Biomolecules |
| locations[0].landing_page_url | https://doi.org/10.3390/biom11081199 |
| locations[1].id | pmid:34439864 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Biomolecules |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34439864 |
| locations[2].id | pmh:oai:doaj.org/article:dac9251508c5416596bb096edabc6880 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Biomolecules, Vol 11, Iss 8, p 1199 (2021) |
| locations[2].landing_page_url | https://doaj.org/article/dac9251508c5416596bb096edabc6880 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:8392613 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Biomolecules |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8392613 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5089564094 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Mizhir Atallah |
| authorships[0].countries | IL |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2799294462 |
| authorships[0].affiliations[0].raw_affiliation_string | Laboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I2799294462 |
| authorships[0].affiliations[1].raw_affiliation_string | Ophthalmology Department, Emek Medical Center, Afula 18101, Israel |
| authorships[0].institutions[0].id | https://openalex.org/I2799294462 |
| authorships[0].institutions[0].ror | https://ror.org/02b988t02 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I2799294462, https://openalex.org/I64767286 |
| authorships[0].institutions[0].country_code | IL |
| authorships[0].institutions[0].display_name | Emek Medical Center |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Mizhir Atallah |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Laboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel, Ophthalmology Department, Emek Medical Center, Afula 18101, Israel |
| authorships[1].author.id | https://openalex.org/A5064790980 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Natalia Edison |
| authorships[1].countries | IL |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I2799294462 |
| authorships[1].affiliations[0].raw_affiliation_string | The Tissue Diagnostics and Cancer Research Institute, Emek Medical Center, Afula 18101, Israel |
| authorships[1].institutions[0].id | https://openalex.org/I2799294462 |
| authorships[1].institutions[0].ror | https://ror.org/02b988t02 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I2799294462, https://openalex.org/I64767286 |
| authorships[1].institutions[0].country_code | IL |
| authorships[1].institutions[0].display_name | Emek Medical Center |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Natalia Edison |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | The Tissue Diagnostics and Cancer Research Institute, Emek Medical Center, Afula 18101, Israel |
| authorships[2].author.id | https://openalex.org/A5071644809 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-1805-9030 |
| authorships[2].author.display_name | E. Levi |
| authorships[2].countries | IL |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2799294462 |
| authorships[2].affiliations[0].raw_affiliation_string | Laboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel |
| authorships[2].institutions[0].id | https://openalex.org/I2799294462 |
| authorships[2].institutions[0].ror | https://ror.org/02b988t02 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I2799294462, https://openalex.org/I64767286 |
| authorships[2].institutions[0].country_code | IL |
| authorships[2].institutions[0].display_name | Emek Medical Center |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Esther Levi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Laboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel |
| authorships[3].author.id | https://openalex.org/A5023003275 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Irit Elmalah |
| authorships[3].countries | IL |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2799294462 |
| authorships[3].affiliations[0].raw_affiliation_string | The Tissue Diagnostics and Cancer Research Institute, Emek Medical Center, Afula 18101, Israel |
| authorships[3].institutions[0].id | https://openalex.org/I2799294462 |
| authorships[3].institutions[0].ror | https://ror.org/02b988t02 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2799294462, https://openalex.org/I64767286 |
| authorships[3].institutions[0].country_code | IL |
| authorships[3].institutions[0].display_name | Emek Medical Center |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Irit Elmalah |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | The Tissue Diagnostics and Cancer Research Institute, Emek Medical Center, Afula 18101, Israel |
| authorships[4].author.id | https://openalex.org/A5088885226 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-0740-7335 |
| authorships[4].author.display_name | Daniel Briscoe |
| authorships[4].countries | IL |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I2799294462 |
| authorships[4].affiliations[0].raw_affiliation_string | Laboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I2799294462 |
| authorships[4].affiliations[1].raw_affiliation_string | Ophthalmology Department, Emek Medical Center, Afula 18101, Israel |
| authorships[4].institutions[0].id | https://openalex.org/I2799294462 |
| authorships[4].institutions[0].ror | https://ror.org/02b988t02 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I2799294462, https://openalex.org/I64767286 |
| authorships[4].institutions[0].country_code | IL |
| authorships[4].institutions[0].display_name | Emek Medical Center |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Daniel Briscoe |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Laboratory of Ophthalmic Research, Emek Medical Center, Afula 18101, Israel, Ophthalmology Department, Emek Medical Center, Afula 18101, Israel |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/2218-273X/11/8/1199/pdf?version=1628836713 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | C-KIT Expression in Orbital Cavernous Venous Hemangiomas |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10980 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2746 |
| primary_topic.subfield.display_name | Surgery |
| primary_topic.display_name | Vascular Malformations and Hemangiomas |
| related_works | https://openalex.org/W2353073495, https://openalex.org/W1993669251, https://openalex.org/W2356578833, https://openalex.org/W2364430558, https://openalex.org/W2167062096, https://openalex.org/W2159918272, https://openalex.org/W2367090168, https://openalex.org/W2086989368, https://openalex.org/W2134915497, https://openalex.org/W2411748488 |
| cited_by_count | 3 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 2 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3390/biom11081199 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210236520 |
| best_oa_location.source.issn | 2218-273X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2218-273X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Biomolecules |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/2218-273X/11/8/1199/pdf?version=1628836713 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Biomolecules |
| best_oa_location.landing_page_url | https://doi.org/10.3390/biom11081199 |
| primary_location.id | doi:10.3390/biom11081199 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210236520 |
| primary_location.source.issn | 2218-273X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2218-273X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Biomolecules |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/2218-273X/11/8/1199/pdf?version=1628836713 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Biomolecules |
| primary_location.landing_page_url | https://doi.org/10.3390/biom11081199 |
| publication_date | 2021-08-12 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W6600829549, https://openalex.org/W2053359352, https://openalex.org/W2072282133, https://openalex.org/W2055469815, https://openalex.org/W1970028203, https://openalex.org/W1982964633, https://openalex.org/W2090589146, https://openalex.org/W20521071, https://openalex.org/W2023719869, https://openalex.org/W2104648805, https://openalex.org/W1570625730, https://openalex.org/W1973403102, https://openalex.org/W2070656767, https://openalex.org/W2341184764, https://openalex.org/W2165720262, https://openalex.org/W2171620774, https://openalex.org/W2024510824, https://openalex.org/W2048993739, https://openalex.org/W2119455657, https://openalex.org/W4233154886, https://openalex.org/W2002228338, https://openalex.org/W2061807131, https://openalex.org/W2115590950, https://openalex.org/W2170723552, https://openalex.org/W1974847622, https://openalex.org/W2120667639, https://openalex.org/W1974208182, https://openalex.org/W1988429312, https://openalex.org/W2124877381, https://openalex.org/W1752312133, https://openalex.org/W2037695813, https://openalex.org/W2059780090, https://openalex.org/W2324850882, https://openalex.org/W2147124043, https://openalex.org/W2016086822, https://openalex.org/W6682729648, https://openalex.org/W2055763832, https://openalex.org/W2079420659, https://openalex.org/W2015015957, https://openalex.org/W1993771149, https://openalex.org/W2399991151, https://openalex.org/W84458402, https://openalex.org/W1995232821, https://openalex.org/W1995255092, https://openalex.org/W2038200800, https://openalex.org/W2123903372, https://openalex.org/W2127997861, https://openalex.org/W2082644391, https://openalex.org/W2151504205 |
| referenced_works_count | 49 |
| abstract_inverted_index.6 | 87 |
| abstract_inverted_index.= | 140, 147 |
| abstract_inverted_index.A | 192 |
| abstract_inverted_index.a | 19, 35, 180 |
| abstract_inverted_index.(p | 139, 146 |
| abstract_inverted_index.16 | 61, 67, 113 |
| abstract_inverted_index.22 | 90 |
| abstract_inverted_index.We | 149 |
| abstract_inverted_index.an | 155 |
| abstract_inverted_index.as | 173 |
| abstract_inverted_index.at | 73 |
| abstract_inverted_index.by | 108 |
| abstract_inverted_index.in | 14, 38, 55, 111, 118, 122, 126, 158, 168, 182, 188, 205 |
| abstract_inverted_index.is | 18, 24, 31, 166, 197 |
| abstract_inverted_index.no | 130 |
| abstract_inverted_index.of | 29, 43, 51, 161, 203 |
| abstract_inverted_index.on | 26, 70 |
| abstract_inverted_index.or | 142 |
| abstract_inverted_index.to | 33, 47, 199 |
| abstract_inverted_index.All | 94 |
| abstract_inverted_index.Our | 57 |
| abstract_inverted_index.The | 16, 41, 77, 104 |
| abstract_inverted_index.all | 112 |
| abstract_inverted_index.and | 89, 124, 136, 176 |
| abstract_inverted_index.are | 7 |
| abstract_inverted_index.for | 98 |
| abstract_inverted_index.key | 36 |
| abstract_inverted_index.may | 153, 178 |
| abstract_inverted_index.mm. | 83 |
| abstract_inverted_index.the | 8, 49, 52, 99, 109, 143, 159, 189, 201 |
| abstract_inverted_index.two | 119 |
| abstract_inverted_index.was | 46, 81, 106, 116 |
| abstract_inverted_index.18.4 | 82 |
| abstract_inverted_index.Emek | 74 |
| abstract_inverted_index.This | 163 |
| abstract_inverted_index.from | 66 |
| abstract_inverted_index.have | 179 |
| abstract_inverted_index.mean | 78 |
| abstract_inverted_index.most | 9 |
| abstract_inverted_index.play | 34, 154 |
| abstract_inverted_index.role | 37, 157, 181, 202 |
| abstract_inverted_index.six, | 123 |
| abstract_inverted_index.size | 80, 138 |
| abstract_inverted_index.such | 172 |
| abstract_inverted_index.that | 151, 169 |
| abstract_inverted_index.this | 44 |
| abstract_inverted_index.weak | 125 |
| abstract_inverted_index.were | 96 |
| abstract_inverted_index.with | 129 |
| abstract_inverted_index.(slow | 1 |
| abstract_inverted_index.0.69) | 141 |
| abstract_inverted_index.OCVH. | 56, 162, 206 |
| abstract_inverted_index.apex. | 191 |
| abstract_inverted_index.c-KIT | 17, 54, 100, 105, 152, 204 |
| abstract_inverted_index.cases | 68, 186 |
| abstract_inverted_index.eight | 127 |
| abstract_inverted_index.flow) | 2 |
| abstract_inverted_index.large | 193 |
| abstract_inverted_index.pilot | 164 |
| abstract_inverted_index.study | 45, 59, 165, 196 |
| abstract_inverted_index.tumor | 39, 79, 137 |
| abstract_inverted_index.types | 28 |
| abstract_inverted_index.which | 23 |
| abstract_inverted_index.years | 91 |
| abstract_inverted_index.(OCVH) | 6 |
| abstract_inverted_index.0.15). | 148 |
| abstract_inverted_index.before | 92 |
| abstract_inverted_index.benign | 11 |
| abstract_inverted_index.cases, | 120, 128 |
| abstract_inverted_index.cells, | 30 |
| abstract_inverted_index.common | 10 |
| abstract_inverted_index.kinase | 21 |
| abstract_inverted_index.months | 88 |
| abstract_inverted_index.strong | 117 |
| abstract_inverted_index.tumors | 13 |
| abstract_inverted_index.venous | 4, 64 |
| abstract_inverted_index.Center. | 76 |
| abstract_inverted_index.Medical | 75 |
| abstract_inverted_index.Orbital | 0 |
| abstract_inverted_index.adults. | 15 |
| abstract_inverted_index.between | 71, 86, 134 |
| abstract_inverted_index.examine | 200 |
| abstract_inverted_index.located | 187 |
| abstract_inverted_index.orbital | 12, 62, 190 |
| abstract_inverted_index.purpose | 42 |
| abstract_inverted_index.several | 27 |
| abstract_inverted_index.symptom | 144 |
| abstract_inverted_index.therapy | 171 |
| abstract_inverted_index.thought | 32 |
| abstract_inverted_index.through | 102 |
| abstract_inverted_index.Imatinib | 174 |
| abstract_inverted_index.Mesylate | 175 |
| abstract_inverted_index.Staining | 115 |
| abstract_inverted_index.Symptoms | 84 |
| abstract_inverted_index.analyzed | 97 |
| abstract_inverted_index.appeared | 85 |
| abstract_inverted_index.conclude | 150 |
| abstract_inverted_index.duration | 145 |
| abstract_inverted_index.evaluate | 48 |
| abstract_inverted_index.examined | 60 |
| abstract_inverted_index.moderate | 121 |
| abstract_inverted_index.operated | 69 |
| abstract_inverted_index.presence | 50 |
| abstract_inverted_index.receptor | 53, 101 |
| abstract_inverted_index.staining | 135 |
| abstract_inverted_index.treating | 183 |
| abstract_inverted_index.tyrosine | 20 |
| abstract_inverted_index.Sunitinib | 177 |
| abstract_inverted_index.cavernous | 3, 63 |
| abstract_inverted_index.expressed | 25, 107 |
| abstract_inverted_index.important | 156 |
| abstract_inverted_index.necessary | 198 |
| abstract_inverted_index.receptor, | 22 |
| abstract_inverted_index.specimens | 95 |
| abstract_inverted_index.operation. | 93 |
| abstract_inverted_index.surgically | 184 |
| abstract_inverted_index.2006–2016 | 72 |
| abstract_inverted_index.complicated | 185 |
| abstract_inverted_index.correlation | 133 |
| abstract_inverted_index.endothelium | 110 |
| abstract_inverted_index.hemangiomas | 5, 65 |
| abstract_inverted_index.multicenter | 194 |
| abstract_inverted_index.preparates. | 114 |
| abstract_inverted_index.significant | 132, 167 |
| abstract_inverted_index.pathogenesis | 160 |
| abstract_inverted_index.collaborative | 195 |
| abstract_inverted_index.pathogenesis. | 40 |
| abstract_inverted_index.retrospective | 58 |
| abstract_inverted_index.statistically | 131 |
| abstract_inverted_index.tumor-targeted | 170 |
| abstract_inverted_index.immunohistochemistry. | 103 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5088885226 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I2799294462 |
| citation_normalized_percentile.value | 0.69163152 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |