C-peptide and epicardial adipose tissue in dialysis-dependent chronic kidney disease patients Article Swipe
Luis D’Marco
,
Ana Checa-Ros
,
Antonella Locascio
,
OH Okojie
,
Iris Viejo-Boyano
,
Valmore Bermúdez
,
Cristina Karohl
,
Paolo Raggi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2025.1650859
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fmed.2025.1650859
Background Several studies suggest that C-peptide (CP) is involved in regulating lipolysis, adipokine release, and other functions in the adipose tissue. On the other hand, organ-specific adipose tissues, such as the epicardial adipose tissue (EAT), have been reported as an independent cardiovascular risk factor in patients on dialysis. This study aimed to evaluate the association between CP, EAT volume, and coronary artery calcification (CAC) as markers of cardiovascular risk, on subjects with type 2 diabetes receiving insulin and dialysis. Methods This is a retrospective study on 62 patients with chronic kidney disease (CKD) stage 5 on dialysis awaiting kidney transplantation and referred for cardiovascular risk stratification at the Emory University Hospital. Computed tomography (CT) was used to assess CAC and to measure EAT volume. Demographic and anthropometric data were collected from all patients through record review. Results The mean patient age was 43 ± 11 and 55% were women. None of the serum analytical parameters correlated with CP. Subjects with higher BMI exhibited higher levels of CP. EAT volume strongly correlated with CP levels, and it was significantly correlated with CAC. On the contrary, no correlation was found between CP and CAC. Conclusion The significant association between EAT volume and CP suggests a potential role of CP in the cardiovascular physiopathology of patients with ESKD on dialysis. Insufficient statistical power was probably the cause of the lack of association of CP with CAC. Observational prospective studies are required to characterize CP as a cardiovascular risk marker in patients with ESKD.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmed.2025.1650859
- https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1650859/pdf
- OA Status
- gold
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413998707
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413998707Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmed.2025.1650859Digital Object Identifier
- Title
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C-peptide and epicardial adipose tissue in dialysis-dependent chronic kidney disease patientsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-09-04Full publication date if available
- Authors
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Luis D’Marco, Ana Checa-Ros, Antonella Locascio, OH Okojie, Iris Viejo-Boyano, Valmore Bermúdez, Cristina Karohl, Paolo RaggiList of authors in order
- Landing page
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https://doi.org/10.3389/fmed.2025.1650859Publisher landing page
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https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1650859/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2025.1650859/pdfDirect OA link when available
- Concepts
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Adipose tissue, Kidney disease, Dialysis, Medicine, Kidney, Internal medicine, Epicardial adipose tissue, Endocrinology, PathologyTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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57Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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