C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis Article Swipe
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1073/pnas.1501947112
· OA: W1902317134
Significance Recent studies have reported genetic association of chromosome 5 open reading frame 30 ( C5orf30 ) with both rheumatoid arthritis (RA) susceptibility and the severity of radiological damage to joints. The gene is expressed in vertebrate genomes with a high degree of conservation, implying a central function in these organisms. Here, we report that C5orf30 encodes a 206-aa protein that is highly expressed in RA synovial fibroblasts (RASFs), a cell type implicated in causing joint damage. Importantly inhibition of C5orf30 increases the autoaggressive phenotype of RASFs in vitro and increases joint inflammation and damage in murine inflammatory arthritis. Our data reveals C5orf30 to be a negative regulator of tissue breakdown modulating the autoaggressive phenotype that is characteristic of RASFs.
