Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity Article Swipe
Audrey T. Medeiros
,
Scott J. Gratz
,
A. Delgado
,
Jason T. Ritt
,
Kate M. O’Connor-Giles
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.88412
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7554/elife.88412
Synaptic heterogeneity is a hallmark of nervous systems that enables complex and adaptable communication in neural circuits. To understand circuit function, it is thus critical to determine the factors that contribute to the functional diversity of synapses. We investigated the contributions of voltage-gated calcium channel (VGCC) abundance, spatial organization, and subunit composition to synapse diversity among and between synapses formed by two closely related Drosophila glutamatergic motor neurons with distinct neurotransmitter release probabilities (P r ). Surprisingly, VGCC levels are highly predictive of heterogeneous P r among individual synapses of either low- or high-P r inputs, but not between inputs. We find that the same number of VGCCs are more densely organized at high-P r synapses, consistent with tighter VGCC-synaptic vesicle coupling. We generated endogenously tagged lines to investigate VGCC subunits in vivo and found that the α2δ–3 subunit Straightjacket along with the CAST/ELKS active zone (AZ) protein Bruchpilot, both key regulators of VGCCs, are less abundant at high-P r inputs, yet positively correlate with P r among synapses formed by either input. Consistently, both Straightjacket and Bruchpilot levels are dynamically increased across AZs of both inputs when neurotransmitter release is potentiated to maintain stable communication following glutamate receptor inhibition. Together, these findings suggest a model in which VGCC and AZ protein abundance intersects with input-specific spatial and molecular organization to shape the functional diversity of synapses.
Related Topics
Concepts
Synapse
Abundance (ecology)
Active zone
Neuroscience
Biology
Ecology
Synaptic vesicle
Genetics
Membrane
Vesicle
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.88412
- OA Status
- gold
- Cited By
- 8
- References
- 109
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4384522776
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4384522776Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.88412Digital Object Identifier
- Title
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Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversityWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
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2023-07-17Full publication date if available
- Authors
-
Audrey T. Medeiros, Scott J. Gratz, A. Delgado, Jason T. Ritt, Kate M. O’Connor-GilesList of authors in order
- Landing page
-
https://doi.org/10.7554/elife.88412Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.7554/elife.88412Direct OA link when available
- Concepts
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Synapse, Abundance (ecology), Active zone, Neuroscience, Biology, Ecology, Synaptic vesicle, Genetics, Membrane, VesicleTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 6, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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109Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.synapses. | 36, 226 |
| abstract_inverted_index.α2δ–3 | 137 |
| abstract_inverted_index.Bruchpilot | 177 |
| abstract_inverted_index.Drosophila | 64 |
| abstract_inverted_index.abundance, | 46 |
| abstract_inverted_index.consistent | 116 |
| abstract_inverted_index.contribute | 30 |
| abstract_inverted_index.functional | 33, 223 |
| abstract_inverted_index.individual | 87 |
| abstract_inverted_index.intersects | 213 |
| abstract_inverted_index.positively | 162 |
| abstract_inverted_index.predictive | 81 |
| abstract_inverted_index.regulators | 151 |
| abstract_inverted_index.understand | 18 |
| abstract_inverted_index.Bruchpilot, | 148 |
| abstract_inverted_index.composition | 51 |
| abstract_inverted_index.dynamically | 180 |
| abstract_inverted_index.inhibition. | 199 |
| abstract_inverted_index.investigate | 128 |
| abstract_inverted_index.potentiated | 191 |
| abstract_inverted_index.endogenously | 124 |
| abstract_inverted_index.investigated | 38 |
| abstract_inverted_index.organization | 219 |
| abstract_inverted_index.Consistently, | 173 |
| abstract_inverted_index.Surprisingly, | 76 |
| abstract_inverted_index.VGCC-synaptic | 119 |
| abstract_inverted_index.communication | 13, 195 |
| abstract_inverted_index.contributions | 40 |
| abstract_inverted_index.glutamatergic | 65 |
| abstract_inverted_index.heterogeneity | 1 |
| abstract_inverted_index.heterogeneous | 83 |
| abstract_inverted_index.organization, | 48 |
| abstract_inverted_index.probabilities | 72 |
| abstract_inverted_index.voltage-gated | 42 |
| abstract_inverted_index.Straightjacket | 139, 175 |
| abstract_inverted_index.input-specific | 215 |
| abstract_inverted_index.neurotransmitter | 70, 188 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| citation_normalized_percentile.value | 0.80759554 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |