Calcium Supplementation in Pregnancy: A Systematic Review of Clinical Studies Article Swipe
Angeliki Gerede
,
Panayiota Papasozomenou
,
Sofoklis Stavros
,
Anastasios Potiris
,
Ekaterini Domali
,
Nikolaos Nikolettos
,
Makarios Eleftheriades
,
Μenelaos Zafrakas
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/medicina61071195
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/medicina61071195
Background and Objectives: Calcium is an essential mineral that plays a vital role in fetal development and maternal health during pregnancy. The World Health Organization recommends a daily calcium intake of 1.5–2 g for pregnant adult women. Calcium deficiency during gestation may lead to complications, such as gestational hypertension, preeclampsia, loss of bone mineral density, impaired fetal development, and other adverse pregnancy outcomes. The aim of the present review is to evaluate the current clinical evidence on calcium intake during pregnancy. Methods: The present systematic review was conducted according to the PRISMA 2020 statement by searching two major databases, PubMed and Mendeley. The study protocol was registered in the Open Science Framework (DOI: osf.io/rvj7z). Inclusion criteria were clinical trials on calcium supplementation during pregnancy. Exclusion criteria were clinical guidelines, reviews, case reports, case series, letters, and commentaries. The Newcastle–Ottawa Scale was used to assess the risk of bias in the included studies. Results: Initially, 451 publications were identified, and after removal of duplicates and screening of titles and/or abstracts and/or full texts, 34 studies were included. The number of participants ranged between 30 and 22,000 women. Calcium supplementation was associated with lower incidence of and less severe gestational hypertension and preeclampsia, lower risk of preterm birth, longer pregnancy duration and higher neonatal birth weight, and improved maternal bone mineral density postpartum. When the doses were split up into smaller doses, the benefits were strongest with high-dose regimens (1.5–2 g/day). Conclusions: Calcium supplementation during pregnancy has beneficial effects on maternal and neonatal health, especially in populations with insufficient dietary daily calcium intake and women at high risk of hypertensive disorders. Daily dose may vary according to individual needs, daily dietary calcium intake, and general health status. Further large-scale randomized controlled trials (RCTs) are necessary to confirm these findings.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/medicina61071195
- https://www.mdpi.com/1648-9144/61/7/1195/pdf?version=1751290247
- OA Status
- gold
- References
- 84
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411803966
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4411803966Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/medicina61071195Digital Object Identifier
- Title
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Calcium Supplementation in Pregnancy: A Systematic Review of Clinical StudiesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-06-30Full publication date if available
- Authors
-
Angeliki Gerede, Panayiota Papasozomenou, Sofoklis Stavros, Anastasios Potiris, Ekaterini Domali, Nikolaos Nikolettos, Makarios Eleftheriades, Μenelaos ZafrakasList of authors in order
- Landing page
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https://doi.org/10.3390/medicina61071195Publisher landing page
- PDF URL
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https://www.mdpi.com/1648-9144/61/7/1195/pdf?version=1751290247Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1648-9144/61/7/1195/pdf?version=1751290247Direct OA link when available
- Concepts
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Medicine, Pregnancy, Preeclampsia, Gestational hypertension, Obstetrics, Calcium supplementation, Inclusion and exclusion criteria, Clinical trial, Gestation, Birth weight, Gestational age, Calcium, Pediatrics, Internal medicine, Alternative medicine, Genetics, Biology, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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84Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Further | 285 |
| abstract_inverted_index.Science | 110 |
| abstract_inverted_index.adverse | 60 |
| abstract_inverted_index.between | 181 |
| abstract_inverted_index.calcium | 28, 77, 120, 259, 279 |
| abstract_inverted_index.confirm | 294 |
| abstract_inverted_index.current | 73 |
| abstract_inverted_index.density | 219 |
| abstract_inverted_index.dietary | 257, 278 |
| abstract_inverted_index.effects | 246 |
| abstract_inverted_index.g/day). | 238 |
| abstract_inverted_index.general | 282 |
| abstract_inverted_index.health, | 251 |
| abstract_inverted_index.intake, | 280 |
| abstract_inverted_index.mineral | 7, 53, 218 |
| abstract_inverted_index.present | 67, 83 |
| abstract_inverted_index.preterm | 204 |
| abstract_inverted_index.removal | 160 |
| abstract_inverted_index.series, | 133 |
| abstract_inverted_index.smaller | 228 |
| abstract_inverted_index.status. | 284 |
| abstract_inverted_index.studies | 173 |
| abstract_inverted_index.weight, | 213 |
| abstract_inverted_index.(1.5–2 | 237 |
| abstract_inverted_index.Methods: | 81 |
| abstract_inverted_index.Results: | 152 |
| abstract_inverted_index.benefits | 231 |
| abstract_inverted_index.clinical | 74, 117, 127 |
| abstract_inverted_index.criteria | 115, 125 |
| abstract_inverted_index.density, | 54 |
| abstract_inverted_index.duration | 208 |
| abstract_inverted_index.evaluate | 71 |
| abstract_inverted_index.evidence | 75 |
| abstract_inverted_index.impaired | 55 |
| abstract_inverted_index.improved | 215 |
| abstract_inverted_index.included | 150 |
| abstract_inverted_index.letters, | 134 |
| abstract_inverted_index.maternal | 17, 216, 248 |
| abstract_inverted_index.neonatal | 211, 250 |
| abstract_inverted_index.pregnant | 34 |
| abstract_inverted_index.protocol | 104 |
| abstract_inverted_index.regimens | 236 |
| abstract_inverted_index.reports, | 131 |
| abstract_inverted_index.reviews, | 129 |
| abstract_inverted_index.studies. | 151 |
| abstract_inverted_index.Exclusion | 124 |
| abstract_inverted_index.Framework | 111 |
| abstract_inverted_index.Inclusion | 114 |
| abstract_inverted_index.Mendeley. | 101 |
| abstract_inverted_index.abstracts | 168 |
| abstract_inverted_index.according | 88, 273 |
| abstract_inverted_index.conducted | 87 |
| abstract_inverted_index.essential | 6 |
| abstract_inverted_index.findings. | 296 |
| abstract_inverted_index.gestation | 40 |
| abstract_inverted_index.high-dose | 235 |
| abstract_inverted_index.incidence | 192 |
| abstract_inverted_index.included. | 175 |
| abstract_inverted_index.necessary | 292 |
| abstract_inverted_index.outcomes. | 62 |
| abstract_inverted_index.pregnancy | 61, 207, 243 |
| abstract_inverted_index.screening | 164 |
| abstract_inverted_index.searching | 95 |
| abstract_inverted_index.statement | 93 |
| abstract_inverted_index.strongest | 233 |
| abstract_inverted_index.Background | 0 |
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| abstract_inverted_index.associated | 189 |
| abstract_inverted_index.beneficial | 245 |
| abstract_inverted_index.controlled | 288 |
| abstract_inverted_index.databases, | 98 |
| abstract_inverted_index.deficiency | 38 |
| abstract_inverted_index.disorders. | 268 |
| abstract_inverted_index.duplicates | 162 |
| abstract_inverted_index.especially | 252 |
| abstract_inverted_index.individual | 275 |
| abstract_inverted_index.pregnancy. | 20, 80, 123 |
| abstract_inverted_index.randomized | 287 |
| abstract_inverted_index.recommends | 25 |
| abstract_inverted_index.registered | 106 |
| abstract_inverted_index.systematic | 84 |
| abstract_inverted_index.Objectives: | 2 |
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| abstract_inverted_index.gestational | 47, 197 |
| abstract_inverted_index.guidelines, | 128 |
| abstract_inverted_index.identified, | 157 |
| abstract_inverted_index.large-scale | 286 |
| abstract_inverted_index.populations | 254 |
| abstract_inverted_index.postpartum. | 220 |
| abstract_inverted_index.Conclusions: | 239 |
| abstract_inverted_index.Organization | 24 |
| abstract_inverted_index.development, | 57 |
| abstract_inverted_index.hypertension | 198 |
| abstract_inverted_index.hypertensive | 267 |
| abstract_inverted_index.insufficient | 256 |
| abstract_inverted_index.participants | 179 |
| abstract_inverted_index.publications | 155 |
| abstract_inverted_index.commentaries. | 136 |
| abstract_inverted_index.hypertension, | 48 |
| abstract_inverted_index.preeclampsia, | 49, 200 |
| abstract_inverted_index.complications, | 44 |
| abstract_inverted_index.osf.io/rvj7z). | 113 |
| abstract_inverted_index.supplementation | 121, 187, 241 |
| abstract_inverted_index.Newcastle–Ottawa | 138 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.800000011920929 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.31675085 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |