Frontiers in Genetics • Vol 12
Calculation of Similarity Between 26 Autoimmune Diseases Based on Three Measurements Including Network, Function, and Semantics
November 2021 • Yanjun Ding, Mintian Cui, Jun Qian, Chao Wang, Shen Qi, Hongbiao Ren, Liangshuang Li, Fengmin Zhang, Ruijie Zhang
Autoimmune diseases (ADs) are a broad range of diseases in which the immune response to self-antigens causes damage or disorder of tissues, and the genetic susceptibility is regarded as the key etiology of ADs. Accumulating evidence has suggested that there are certain commonalities among different ADs. However, the theoretical research about similarity between ADs is still limited. In this work, we first computed the genetic similarity between 26 ADs based on three measurements: network similarity (NetSim), funct…