Can Diffusion Tensor Imaging Apparent Diffusion Coefficient Diagnose Carpal Tunnel Syndrome? A Systematic Review and Meta-Analysis Article Swipe
Adam G. Evans
,
Maurice D. Morgan
,
Benjamin A. Aiken
,
Patrick E. Assi
,
Jeremy T. Joseph
,
Tigran Kesayan
,
Lauren M. Mioton
,
Isaac V. Manzanera Esteve
,
J. Bradford Hill
,
Wesley P. Thayer
,
Salam Al Kassis
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/15589447221096706
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1177/15589447221096706
Magnetic resonance diffusion tensor imaging (DTI) can detect microstructural changes in peripheral nerves. Studies have reported that the median nerve apparent diffusion coefficient (ADC), a quantification of water molecule diffusion direction, is sensitive in diagnosing carpal tunnel syndrome (CTS). Five databases were searched for studies using ADC to investigate CTS. Apparent diffusion coefficient (measured in mm 2 /s) were pooled in random-effects meta-analyses. Twenty-two studies met criteria yielding 592 patients with CTS and 414 controls. Median nerve ADC were measured at the level of the distal radioulnar joint (CTS ADC: 1.11, 95% CI: 1.07-1.15, I 2 = 54%; control ADC: 1.04, 95% CI: 1.01-1.07, I 2 = 57%), pisiform (CTS ADC: 1.39, 95% CI: 1.37-1.42, I 2 = 0%; control ADC: 1.27, 95% CI: 1.23-1.31, I 2 = 59%), hamate (CTS ADC: 1.40, 95% CI: 1.36-1.43, I 2 = 58%; control ADC: 1.27, 95% CI: 1.25-1.28, I 2 = 47%), and as an combination of several measurements (CTS ADC: 1.40, 95% CI: 1.37-1.47, I 2 = 100%; control ADC: 1.39, 95% CI: 1.24-1.53, I 2 = 100%). Median nerve ADC is decreased in individuals with CTS compared to controls at the levels of the hamate and pisiform. ADC cut-offs to diagnose CTS should be established according to these anatomic levels and can be improved through additional studies that include use of a wrist coil.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1177/15589447221096706
- OA Status
- green
- Cited By
- 7
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4282545963
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4282545963Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1177/15589447221096706Digital Object Identifier
- Title
-
Can Diffusion Tensor Imaging Apparent Diffusion Coefficient Diagnose Carpal Tunnel Syndrome? A Systematic Review and Meta-AnalysisWork title
- Type
-
reviewOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-06-13Full publication date if available
- Authors
-
Adam G. Evans, Maurice D. Morgan, Benjamin A. Aiken, Patrick E. Assi, Jeremy T. Joseph, Tigran Kesayan, Lauren M. Mioton, Isaac V. Manzanera Esteve, J. Bradford Hill, Wesley P. Thayer, Salam Al KassisList of authors in order
- Landing page
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https://doi.org/10.1177/15589447221096706Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/9896277Direct OA link when available
- Concepts
-
Medicine, Effective diffusion coefficient, Diffusion MRI, Carpal tunnel syndrome, Magnetic resonance imaging, Median nerve, Nuclear medicine, Wrist, Radiology, SurgeryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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