Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female Mice Article Swipe
Richard A. Miller
,
David E. Harrison
,
David B. Allison
,
Molly A. Bogue
,
Vivian Diaz
,
Elizabeth Fernández
,
Andrzej T. Gałecki
,
W. Timothy Garvey
,
Navasuja Kumar
,
Martin A. Javors
,
Warren Ladiges
,
Francesca Macchiarini
,
James F. Nelson
,
Peter C. Reifsnyder
,
Nadia Rosenthal
,
Adam B. Salmon
,
Daniel L. Smith
,
Jessica M. Snyder
,
David B. Lombard
,
Randy Strong
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.23.112763
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1101/2020.05.23.112763
Canagliflozin (Cana) is an inhibitor of the sodium glucose transporter 2 (SGLT2), and is thought to act by blocking renal reuptake and intestinal absorption of glucose. Cana is FDA-approved for treatment of diabetes, and affords protection from cardiovascular and kidney diseases. In the context of the mouse Interventions Testing Program, genetically heterogeneous mice were given chow containing 180 ppm Cana at 7 months of age until their death. Cana extended median survival of male mice by 14%, with p < 0.001 by log-rank test. Cana also increased by 9% the age for 90 th percentile survival (p < 0.001 by Wang/Allison test), with parallel effects seen at each of three test sites. Cana did not alter the distribution of inferred cause of death, nor of incidental pathology findings at end-of-life necropsies. No benefits were seen in female mice. The lifespan benefit of Cana is likely to reflect blunting of peak glucose levels, because similar longevity effects are seen in mice given acarbose, a diabetes drug that blocks glucose surges through a distinct mechanism, i.e. slowing breakdown of carbohydrate in the intestine. Interventions that control daily peak glucose levels deserve attention as possible preventive medicines to protect from a wide range of late-life neoplastic and degenerative diseases.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2020.05.23.112763
- https://www.biorxiv.org/content/biorxiv/early/2020/05/26/2020.05.23.112763.full.pdf
- OA Status
- green
- Cited By
- 12
- References
- 47
- Related Works
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- OpenAlex ID
- https://openalex.org/W3031832889
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3031832889Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2020.05.23.112763Digital Object Identifier
- Title
-
Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female MiceWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-05-26Full publication date if available
- Authors
-
Richard A. Miller, David E. Harrison, David B. Allison, Molly A. Bogue, Vivian Diaz, Elizabeth Fernández, Andrzej T. Gałecki, W. Timothy Garvey, Navasuja Kumar, Martin A. Javors, Warren Ladiges, Francesca Macchiarini, James F. Nelson, Peter C. Reifsnyder, Nadia Rosenthal, Adam B. Salmon, Daniel L. Smith, Jessica M. Snyder, David B. Lombard, Randy StrongList of authors in order
- Landing page
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https://doi.org/10.1101/2020.05.23.112763Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2020/05/26/2020.05.23.112763.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.biorxiv.org/content/biorxiv/early/2020/05/26/2020.05.23.112763.full.pdfDirect OA link when available
- Concepts
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Canagliflozin, Acarbose, Diabetes mellitus, Context (archaeology), Medicine, Glucose transporter, Internal medicine, Endocrinology, Longevity, Physiology, Type 2 diabetes, Biology, Gerontology, Insulin, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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12Total citation count in OpenAlex
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2025: 3, 2024: 1, 2023: 5, 2021: 3Per-year citation counts (last 5 years)
- References (count)
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47Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.death. | 68 |
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| corresponding_author_ids | https://openalex.org/A5066597539 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 20 |
| corresponding_institution_ids | https://openalex.org/I27837315 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6800000071525574 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.83825377 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |