Cancer during Pregnancy: A Review of Preclinical and Clinical Transplacental Transfer of Anticancer Agents Article Swipe

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Laure Benoit , Olivier Mir , François Vialard , Paul Berveiller ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.3390/cancers13061238

The occurrence of cancer during pregnancy is observed in 1 in 1000 pregnancies and is expected to increase given the trend of delaying childbearing. While breast cancer is the most common, the incidence of other cancers, such as cervical, ovarian, and lung cancers as well as hemopathies and melanomas, is also increasing. Thus, cancer occurrence in pregnant women raises questions of management during pregnancy and, especially, assessment of the treatment benefit–risk ratio to ensure optimal management for the mother while ensuring the safety of the fetus. Chemotherapy remains a cornerstone of cancer management. If the use of anticancer agents appears possible during pregnancy, while avoiding the first trimester, the extent of placental transfer of different anticancer agents varies considerably thereafter. Furthermore, the significant physiological pharmacokinetic variations observed in pregnant women may have an impact on the placental transfer of anticancer agents. Given the complexity of predicting placental transfer of anticancer agents, preclinical studies are therefore mandatory. The aim of this review was to provide updated data on in vivo and ex vivo transplacental transfer of anticancer agents used in the management of the most common pregnancy-associated cancers to better manage these highly complex cases.

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Transplacental Medicine Pregnancy Cancer Ovarian cancer Fetus Placenta Obstetrics Oncology Internal medicine Biology Genetics

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Type: review
Language: en
Landing Page: https://doi.org/10.3390/cancers13061238
PDF: https://www.mdpi.com/2072-6694/13/6/1238/pdf?version=1615474413
OA Status: gold
Cited By: 41
References: 158
Related Works: 10
OpenAlex ID: https://openalex.org/W3133493500

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OpenAlex ID: https://openalex.org/W3133493500

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DOI: https://doi.org/10.3390/cancers13061238

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Title: Cancer during Pregnancy: A Review of Preclinical and Clinical Transplacental Transfer of Anticancer Agents

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Type: review

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Language: en

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Publication year: 2021

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Publication date: 2021-03-11

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Authors: Laure Benoit, Olivier Mir, François Vialard, Paul Berveiller

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Landing page: https://doi.org/10.3390/cancers13061238

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PDF URL: https://www.mdpi.com/2072-6694/13/6/1238/pdf?version=1615474413

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OA URL: https://www.mdpi.com/2072-6694/13/6/1238/pdf?version=1615474413

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Concepts: Transplacental, Medicine, Pregnancy, Cancer, Ovarian cancer, Fetus, Placenta, Obstetrics, Oncology, Internal medicine, Biology, Genetics

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Cited by: 41

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Citations by year (recent): 2025: 13, 2024: 12, 2023: 8, 2022: 5, 2021: 2

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