Candidacidal and Antibiofilm Activity of PS1-3 Peptide against Drug-Resistant Candida albicans on Contact Lenses Article Swipe
Jong‐Kook Lee
,
So‐Young Park
,
Young‐Min Kim
,
Taeuk Guk
,
Min Young Lee
,
Seong‐Cheol Park
,
Jung Ro Lee
,
Mi-Kyeong Jang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics14081602
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics14081602
The recent emergence of antibiotic-resistant fungi has accelerated research on novel antifungal agents. In particular, Candida albicans infections are related to biofilm formation on medical devices, such as catheters, stents, and contact lenses, resulting in high morbidity and mortality. In this study, we aimed to elucidate the antifungal and antibiofilm effects of a peptide against drug-resistant C. albicans. α-Helical peptides in which the sequence of KWYK was repeated twice and four times, designated peptide series 1 (PS1)-1 and PS1-3, respectively, were generated, and the candidacidal activities of PS1-1, PS1-3, and fluconazole against drug-resistant C. albicans cells were assessed. The PS1-3 peptide showed higher killing activity than PS1-1 or fluconazole and acted via a membranolytic mechanism. In addition, the PS1-3 peptide exhibited more potent activity than PS1-1 and fluconazole in terms of fungal biofilm inhibition and reduction at the minimum fungicidal concentration on the contact lens surface. Overall, these findings established PS1-3 as a potential candidacidal agent for applications on contact lenses.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics14081602
- https://www.mdpi.com/1999-4923/14/8/1602/pdf?version=1659260199
- OA Status
- gold
- Cited By
- 8
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4289204369
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4289204369Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/pharmaceutics14081602Digital Object Identifier
- Title
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Candidacidal and Antibiofilm Activity of PS1-3 Peptide against Drug-Resistant Candida albicans on Contact LensesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-07-31Full publication date if available
- Authors
-
Jong‐Kook Lee, So‐Young Park, Young‐Min Kim, Taeuk Guk, Min Young Lee, Seong‐Cheol Park, Jung Ro Lee, Mi-Kyeong JangList of authors in order
- Landing page
-
https://doi.org/10.3390/pharmaceutics14081602Publisher landing page
- PDF URL
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https://www.mdpi.com/1999-4923/14/8/1602/pdf?version=1659260199Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4923/14/8/1602/pdf?version=1659260199Direct OA link when available
- Concepts
-
Candida albicans, Fluconazole, Biofilm, Microbiology, Peptide, Contact lens, Corpus albicans, Antifungal drug, Antifungal, Drug, Chemistry, Biology, Medicine, Pharmacology, Bacteria, Biochemistry, Genetics, OphthalmologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 4, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
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25Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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