Candidate Biological Markers for Social Anxiety Disorder: A Systematic Review Article Swipe
Alice Caldiroli
,
Enrico Capuzzi
,
Letizia Maria Affaticati
,
Teresa Surace
,
Carla Di Forti
,
Antonios Dakanalis
,
Massimo Clerici
,
Massimiliano Buoli
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24010835
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24010835
Social anxiety disorder (SAD) is a common psychiatric condition associated with a high risk of psychiatric comorbidity and impaired social/occupational functioning when not promptly treated. The identification of biological markers may facilitate the diagnostic process, leading to an early and proper treatment. Our aim was to systematically review the available literature about potential biomarkers for SAD. A search in the main online repositories (PubMed, ISI Web of Knowledge, PsychInfo, etc.) was performed. Of the 662 records screened, 61 were included. Results concerning cortisol, neuropeptides and inflammatory/immunological/neurotrophic markers remain inconsistent. Preliminary evidence emerged about the role of chromosome 16 and the endomannosidase gene, as well as of epigenetic factors, in increasing vulnerability to SAD. Neuroimaging findings revealed an altered connectivity of different cerebral areas in SAD patients and amygdala activation under social threat. Some parameters such as salivary alpha amylase levels, changes in antioxidant defenses, increased gaze avoidance and QT dispersion seem to be associated with SAD and may represent promising biomarkers of this condition. However, the preliminary positive correlations have been poorly replicated. Further studies on larger samples and investigating the same biomarkers are needed to identify more specific biological markers for SAD.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms24010835
- https://www.mdpi.com/1422-0067/24/1/835/pdf?version=1672808883
- OA Status
- gold
- Cited By
- 19
- References
- 166
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4313466441
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- DOI
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https://doi.org/10.3390/ijms24010835Digital Object Identifier
- Title
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Candidate Biological Markers for Social Anxiety Disorder: A Systematic ReviewWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-03Full publication date if available
- Authors
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Alice Caldiroli, Enrico Capuzzi, Letizia Maria Affaticati, Teresa Surace, Carla Di Forti, Antonios Dakanalis, Massimo Clerici, Massimiliano BuoliList of authors in order
- Landing page
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https://doi.org/10.3390/ijms24010835Publisher landing page
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https://www.mdpi.com/1422-0067/24/1/835/pdf?version=1672808883Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/24/1/835/pdf?version=1672808883Direct OA link when available
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Social anxiety, Clinical psychology, Anxiety, Comorbidity, Psychology, Autism spectrum disorder, Medicine, Psychiatry, Bioinformatics, Autism, BiologyTop concepts (fields/topics) attached by OpenAlex
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19Total citation count in OpenAlex
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2025: 5, 2024: 8, 2023: 6Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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