Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil Article Swipe

View

Bingxue Yang , Xinran Xie , Dazhao Lv , Jiajun Hu , Yuyun Chen , Zhaoyu Wu , Shuyue Luo , Shiyi Zhang ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.1038/s41416-022-02039-3

Related Topics

Concepts

Capecitabine Thymidine phosphorylase Toxicity Pharmacology Cytotoxicity Chemistry Metabolite Cancer research In vitro Internal medicine Medicine Biochemistry Cancer Enzyme Colorectal cancer

Metadata

Type: article
Language: en
Landing Page: https://doi.org/10.1038/s41416-022-02039-3
OA Status: green
Cited By: 16
References: 46
Related Works: 10
OpenAlex ID: https://openalex.org/W4308517569

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4308517569

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1038/s41416-022-02039-3

Digital Object Identifier
Title: Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil

Work title
Type: article

OpenAlex work type
Language: en

Primary language
Publication year: 2022

Year of publication
Publication date: 2022-11-08

Full publication date if available
Authors: Bingxue Yang, Xinran Xie, Dazhao Lv, Jiajun Hu, Yuyun Chen, Zhaoyu Wu, Shuyue Luo, Shiyi Zhang

List of authors in order
Landing page: https://doi.org/10.1038/s41416-022-02039-3

Publisher landing page
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://www.ncbi.nlm.nih.gov/pmc/articles/9902485

Direct OA link when available
Concepts: Capecitabine, Thymidine phosphorylase, Toxicity, Pharmacology, Cytotoxicity, Chemistry, Metabolite, Cancer research, In vitro, Internal medicine, Medicine, Biochemistry, Cancer, Enzyme, Colorectal cancer

Top concepts (fields/topics) attached by OpenAlex
Cited by: 16

Total citation count in OpenAlex
Citations by year (recent): 2025: 7, 2024: 7, 2023: 2

Per-year citation counts (last 5 years)
References (count): 46

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4308517569
doi	https://doi.org/10.1038/s41416-022-02039-3
ids.doi	https://doi.org/10.1038/s41416-022-02039-3
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/36347964
ids.openalex	https://openalex.org/W4308517569
fwci	5.11583681
mesh[0].qualifier_ui
mesh[0].descriptor_ui	D000818
mesh[0].is_major_topic	False
mesh[0].qualifier_name
mesh[0].descriptor_name	Animals
mesh[1].qualifier_ui
mesh[1].descriptor_ui	D051379
mesh[1].is_major_topic	False
mesh[1].qualifier_name
mesh[1].descriptor_name	Mice
mesh[2].qualifier_ui	Q000494
mesh[2].descriptor_ui	D000069287
mesh[2].is_major_topic	False
mesh[2].qualifier_name	pharmacology
mesh[2].descriptor_name	Capecitabine
mesh[3].qualifier_ui	Q000494
mesh[3].descriptor_ui	D005472
mesh[3].is_major_topic	True
mesh[3].qualifier_name	pharmacology
mesh[3].descriptor_name	Fluorouracil
mesh[4].qualifier_ui	Q000188
mesh[4].descriptor_ui	D060831
mesh[4].is_major_topic	True
mesh[4].qualifier_name	drug therapy
mesh[4].descriptor_name	Hand-Foot Syndrome
mesh[5].qualifier_ui	Q000209
mesh[5].descriptor_ui	D060831
mesh[5].is_major_topic	True
mesh[5].qualifier_name	etiology
mesh[5].descriptor_name	Hand-Foot Syndrome
mesh[6].qualifier_ui
mesh[6].descriptor_ui	D000069292
mesh[6].is_major_topic	False
mesh[6].qualifier_name
mesh[6].descriptor_name	Pyroptosis
mesh[7].qualifier_ui	Q000235
mesh[7].descriptor_ui	D013939
mesh[7].is_major_topic	False
mesh[7].qualifier_name	genetics
mesh[7].descriptor_name	Thymidine Phosphorylase
mesh[8].qualifier_ui	Q000378
mesh[8].descriptor_ui	D013939
mesh[8].is_major_topic	False
mesh[8].qualifier_name	metabolism
mesh[8].descriptor_name	Thymidine Phosphorylase
mesh[9].qualifier_ui
mesh[9].descriptor_ui	D011788
mesh[9].is_major_topic	False
mesh[9].qualifier_name
mesh[9].descriptor_name	Quality of Life
mesh[10].qualifier_ui	Q000009
mesh[10].descriptor_ui	D003841
mesh[10].is_major_topic	False
mesh[10].qualifier_name	adverse effects
mesh[10].descriptor_name	Deoxycytidine
mesh[11].qualifier_ui
mesh[11].descriptor_ui	D000818
mesh[11].is_major_topic	False
mesh[11].qualifier_name
mesh[11].descriptor_name	Animals
mesh[12].qualifier_ui
mesh[12].descriptor_ui	D051379
mesh[12].is_major_topic	False
mesh[12].qualifier_name
mesh[12].descriptor_name	Mice
mesh[13].qualifier_ui	Q000494
mesh[13].descriptor_ui	D000069287
mesh[13].is_major_topic	False
mesh[13].qualifier_name	pharmacology
mesh[13].descriptor_name	Capecitabine
mesh[14].qualifier_ui	Q000494
mesh[14].descriptor_ui	D005472
mesh[14].is_major_topic	True
mesh[14].qualifier_name	pharmacology
mesh[14].descriptor_name	Fluorouracil
mesh[15].qualifier_ui	Q000188
mesh[15].descriptor_ui	D060831
mesh[15].is_major_topic	True
mesh[15].qualifier_name	drug therapy
mesh[15].descriptor_name	Hand-Foot Syndrome
mesh[16].qualifier_ui	Q000209
mesh[16].descriptor_ui	D060831
mesh[16].is_major_topic	True
mesh[16].qualifier_name	etiology
mesh[16].descriptor_name	Hand-Foot Syndrome
mesh[17].qualifier_ui
mesh[17].descriptor_ui	D000069292
mesh[17].is_major_topic	False
mesh[17].qualifier_name
mesh[17].descriptor_name	Pyroptosis
mesh[18].qualifier_ui	Q000235
mesh[18].descriptor_ui	D013939
mesh[18].is_major_topic	False
mesh[18].qualifier_name	genetics
mesh[18].descriptor_name	Thymidine Phosphorylase
mesh[19].qualifier_ui	Q000378
mesh[19].descriptor_ui	D013939
mesh[19].is_major_topic	False
mesh[19].qualifier_name	metabolism
mesh[19].descriptor_name	Thymidine Phosphorylase
mesh[20].qualifier_ui
mesh[20].descriptor_ui	D011788
mesh[20].is_major_topic	False
mesh[20].qualifier_name
mesh[20].descriptor_name	Quality of Life
mesh[21].qualifier_ui	Q000009
mesh[21].descriptor_ui	D003841
mesh[21].is_major_topic	False
mesh[21].qualifier_name	adverse effects
mesh[21].descriptor_name	Deoxycytidine
type	article
title	Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil
biblio.issue	2
biblio.volume	128
biblio.last_page	231
biblio.first_page	219
topics[0].id	https://openalex.org/T12937
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	1.0
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2708
topics[0].subfield.display_name	Dermatology
topics[0].display_name	Chemotherapy-related skin toxicity
topics[1].id	https://openalex.org/T12433
topics[1].field.id	https://openalex.org/fields/27
topics[1].field.display_name	Medicine
topics[1].score	0.9905999898910522
topics[1].domain.id	https://openalex.org/domains/4
topics[1].domain.display_name	Health Sciences
topics[1].subfield.id	https://openalex.org/subfields/2708
topics[1].subfield.display_name	Dermatology
topics[1].display_name	Skin Diseases and Diabetes
topics[2].id	https://openalex.org/T11752
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9835000038146973
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2730
topics[2].subfield.display_name	Oncology
topics[2].display_name	Cancer Treatment and Pharmacology
is_xpac	False
apc_list.value	3790
apc_list.currency	EUR
apc_list.value_usd	4690
apc_paid
concepts[0].id	https://openalex.org/C2777909004
concepts[0].level	4
concepts[0].score	0.951162576675415
concepts[0].wikidata	https://www.wikidata.org/wiki/Q420207
concepts[0].display_name	Capecitabine
concepts[1].id	https://openalex.org/C2776735402
concepts[1].level	3
concepts[1].score	0.8563309907913208
concepts[1].wikidata	https://www.wikidata.org/wiki/Q22038268
concepts[1].display_name	Thymidine phosphorylase
concepts[2].id	https://openalex.org/C29730261
concepts[2].level	2
concepts[2].score	0.74711012840271
concepts[2].wikidata	https://www.wikidata.org/wiki/Q274160
concepts[2].display_name	Toxicity
concepts[3].id	https://openalex.org/C98274493
concepts[3].level	1
concepts[3].score	0.6121271848678589
concepts[3].wikidata	https://www.wikidata.org/wiki/Q128406
concepts[3].display_name	Pharmacology
concepts[4].id	https://openalex.org/C109316439
concepts[4].level	3
concepts[4].score	0.538361132144928
concepts[4].wikidata	https://www.wikidata.org/wiki/Q246181
concepts[4].display_name	Cytotoxicity
concepts[5].id	https://openalex.org/C185592680
concepts[5].level	0
concepts[5].score	0.5173506140708923
concepts[5].wikidata	https://www.wikidata.org/wiki/Q2329
concepts[5].display_name	Chemistry
concepts[6].id	https://openalex.org/C2777477808
concepts[6].level	2
concepts[6].score	0.5017800331115723
concepts[6].wikidata	https://www.wikidata.org/wiki/Q407595
concepts[6].display_name	Metabolite
concepts[7].id	https://openalex.org/C502942594
concepts[7].level	1
concepts[7].score	0.3851393163204193
concepts[7].wikidata	https://www.wikidata.org/wiki/Q3421914
concepts[7].display_name	Cancer research
concepts[8].id	https://openalex.org/C202751555
concepts[8].level	2
concepts[8].score	0.29772713780403137
concepts[8].wikidata	https://www.wikidata.org/wiki/Q221681
concepts[8].display_name	In vitro
concepts[9].id	https://openalex.org/C126322002
concepts[9].level	1
concepts[9].score	0.2949051856994629
concepts[9].wikidata	https://www.wikidata.org/wiki/Q11180
concepts[9].display_name	Internal medicine
concepts[10].id	https://openalex.org/C71924100
concepts[10].level	0
concepts[10].score	0.24781066179275513
concepts[10].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[10].display_name	Medicine
concepts[11].id	https://openalex.org/C55493867
concepts[11].level	1
concepts[11].score	0.19271811842918396
concepts[11].wikidata	https://www.wikidata.org/wiki/Q7094
concepts[11].display_name	Biochemistry
concepts[12].id	https://openalex.org/C121608353
concepts[12].level	2
concepts[12].score	0.15907561779022217
concepts[12].wikidata	https://www.wikidata.org/wiki/Q12078
concepts[12].display_name	Cancer
concepts[13].id	https://openalex.org/C181199279
concepts[13].level	2
concepts[13].score	0.1522819697856903
concepts[13].wikidata	https://www.wikidata.org/wiki/Q8047
concepts[13].display_name	Enzyme
concepts[14].id	https://openalex.org/C526805850
concepts[14].level	3
concepts[14].score	0.0
concepts[14].wikidata	https://www.wikidata.org/wiki/Q188874
concepts[14].display_name	Colorectal cancer
keywords[0].id	https://openalex.org/keywords/capecitabine
keywords[0].score	0.951162576675415
keywords[0].display_name	Capecitabine
keywords[1].id	https://openalex.org/keywords/thymidine-phosphorylase
keywords[1].score	0.8563309907913208
keywords[1].display_name	Thymidine phosphorylase
keywords[2].id	https://openalex.org/keywords/toxicity
keywords[2].score	0.74711012840271
keywords[2].display_name	Toxicity
keywords[3].id	https://openalex.org/keywords/pharmacology
keywords[3].score	0.6121271848678589
keywords[3].display_name	Pharmacology
keywords[4].id	https://openalex.org/keywords/cytotoxicity
keywords[4].score	0.538361132144928
keywords[4].display_name	Cytotoxicity
keywords[5].id	https://openalex.org/keywords/chemistry
keywords[5].score	0.5173506140708923
keywords[5].display_name	Chemistry
keywords[6].id	https://openalex.org/keywords/metabolite
keywords[6].score	0.5017800331115723
keywords[6].display_name	Metabolite
keywords[7].id	https://openalex.org/keywords/cancer-research
keywords[7].score	0.3851393163204193
keywords[7].display_name	Cancer research
keywords[8].id	https://openalex.org/keywords/in-vitro
keywords[8].score	0.29772713780403137
keywords[8].display_name	In vitro
keywords[9].id	https://openalex.org/keywords/internal-medicine
keywords[9].score	0.2949051856994629
keywords[9].display_name	Internal medicine
keywords[10].id	https://openalex.org/keywords/medicine
keywords[10].score	0.24781066179275513
keywords[10].display_name	Medicine
keywords[11].id	https://openalex.org/keywords/biochemistry
keywords[11].score	0.19271811842918396
keywords[11].display_name	Biochemistry
keywords[12].id	https://openalex.org/keywords/cancer
keywords[12].score	0.15907561779022217
keywords[12].display_name	Cancer
keywords[13].id	https://openalex.org/keywords/enzyme
keywords[13].score	0.1522819697856903
keywords[13].display_name	Enzyme
language	en
locations[0].id	doi:10.1038/s41416-022-02039-3
locations[0].is_oa	False
locations[0].source.id	https://openalex.org/S62966998
locations[0].source.issn	0007-0920, 1532-1827
locations[0].source.type	journal
locations[0].source.is_oa	False
locations[0].source.issn_l	0007-0920
locations[0].source.is_core	True
locations[0].source.is_in_doaj	False
locations[0].source.display_name	British Journal of Cancer
locations[0].source.host_organization	https://openalex.org/P4310319965
locations[0].source.host_organization_name	Springer Nature
locations[0].source.host_organization_lineage	https://openalex.org/P4310319965
locations[0].license
locations[0].pdf_url
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	British Journal of Cancer
locations[0].landing_page_url	https://doi.org/10.1038/s41416-022-02039-3
locations[1].id	pmid:36347964
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	British journal of cancer
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/36347964
locations[2].id	pmh:oai:pubmedcentral.nih.gov:9902485
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S2764455111
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	PubMed Central
locations[2].source.host_organization	https://openalex.org/I1299303238
locations[2].source.host_organization_name	National Institutes of Health
locations[2].source.host_organization_lineage	https://openalex.org/I1299303238
locations[2].license
locations[2].pdf_url
locations[2].version	acceptedVersion
locations[2].raw_type	Text
locations[2].license_id
locations[2].is_accepted	True
locations[2].is_published	False
locations[2].raw_source_name	Br J Cancer
locations[2].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/9902485
indexed_in	crossref, pubmed
authorships[0].author.id	https://openalex.org/A5042926956
authorships[0].author.orcid	https://orcid.org/0000-0002-8505-0298
authorships[0].author.display_name	Bingxue Yang
authorships[0].countries	CN
authorships[0].affiliations[0].institution_ids	https://openalex.org/I183067930
authorships[0].affiliations[0].raw_affiliation_string	School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
authorships[0].institutions[0].id	https://openalex.org/I183067930
authorships[0].institutions[0].ror	https://ror.org/0220qvk04
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I183067930
authorships[0].institutions[0].country_code	CN
authorships[0].institutions[0].display_name	Shanghai Jiao Tong University
authorships[0].author_position	first
authorships[0].raw_author_name	Bingxue Yang
authorships[0].is_corresponding	False
authorships[0].raw_affiliation_strings	School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
authorships[1].author.id	https://openalex.org/A5012723797
authorships[1].author.orcid	https://orcid.org/0000-0002-1273-8542
authorships[1].author.display_name	Xinran Xie
authorships[1].countries	CN
authorships[1].affiliations[0].institution_ids	https://openalex.org/I183067930
authorships[1].affiliations[0].raw_affiliation_string	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[1].institutions[0].id	https://openalex.org/I183067930
authorships[1].institutions[0].ror	https://ror.org/0220qvk04
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I183067930
authorships[1].institutions[0].country_code	CN
authorships[1].institutions[0].display_name	Shanghai Jiao Tong University
authorships[1].author_position	middle
authorships[1].raw_author_name	Xinran Xie
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[2].author.id	https://openalex.org/A5041817572
authorships[2].author.orcid
authorships[2].author.display_name	Dazhao Lv
authorships[2].countries	CN
authorships[2].affiliations[0].institution_ids	https://openalex.org/I183067930
authorships[2].affiliations[0].raw_affiliation_string	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[2].institutions[0].id	https://openalex.org/I183067930
authorships[2].institutions[0].ror	https://ror.org/0220qvk04
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I183067930
authorships[2].institutions[0].country_code	CN
authorships[2].institutions[0].display_name	Shanghai Jiao Tong University
authorships[2].author_position	middle
authorships[2].raw_author_name	Dazhao Lv
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[3].author.id	https://openalex.org/A5006459972
authorships[3].author.orcid
authorships[3].author.display_name	Jiajun Hu
authorships[3].countries	CN
authorships[3].affiliations[0].institution_ids	https://openalex.org/I183067930
authorships[3].affiliations[0].raw_affiliation_string	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[3].institutions[0].id	https://openalex.org/I183067930
authorships[3].institutions[0].ror	https://ror.org/0220qvk04
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I183067930
authorships[3].institutions[0].country_code	CN
authorships[3].institutions[0].display_name	Shanghai Jiao Tong University
authorships[3].author_position	middle
authorships[3].raw_author_name	Jiajun Hu
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[4].author.id	https://openalex.org/A5074611149
authorships[4].author.orcid	https://orcid.org/0000-0002-7070-800X
authorships[4].author.display_name	Yuyun Chen
authorships[4].countries	CN
authorships[4].affiliations[0].institution_ids	https://openalex.org/I183067930
authorships[4].affiliations[0].raw_affiliation_string	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[4].institutions[0].id	https://openalex.org/I183067930
authorships[4].institutions[0].ror	https://ror.org/0220qvk04
authorships[4].institutions[0].type	education
authorships[4].institutions[0].lineage	https://openalex.org/I183067930
authorships[4].institutions[0].country_code	CN
authorships[4].institutions[0].display_name	Shanghai Jiao Tong University
authorships[4].author_position	middle
authorships[4].raw_author_name	Yuyun Chen
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[5].author.id	https://openalex.org/A5103007575
authorships[5].author.orcid	https://orcid.org/0000-0001-6512-1557
authorships[5].author.display_name	Zhaoyu Wu
authorships[5].countries	CN
authorships[5].affiliations[0].institution_ids	https://openalex.org/I183067930
authorships[5].affiliations[0].raw_affiliation_string	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[5].institutions[0].id	https://openalex.org/I183067930
authorships[5].institutions[0].ror	https://ror.org/0220qvk04
authorships[5].institutions[0].type	education
authorships[5].institutions[0].lineage	https://openalex.org/I183067930
authorships[5].institutions[0].country_code	CN
authorships[5].institutions[0].display_name	Shanghai Jiao Tong University
authorships[5].author_position	middle
authorships[5].raw_author_name	Zhaoyu Wu
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[6].author.id	https://openalex.org/A5075208730
authorships[6].author.orcid
authorships[6].author.display_name	Shuyue Luo
authorships[6].countries	CN
authorships[6].affiliations[0].institution_ids	https://openalex.org/I183067930
authorships[6].affiliations[0].raw_affiliation_string	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[6].institutions[0].id	https://openalex.org/I183067930
authorships[6].institutions[0].ror	https://ror.org/0220qvk04
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I183067930
authorships[6].institutions[0].country_code	CN
authorships[6].institutions[0].display_name	Shanghai Jiao Tong University
authorships[6].author_position	middle
authorships[6].raw_author_name	Shuyue Luo
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[7].author.id	https://openalex.org/A5100784918
authorships[7].author.orcid	https://orcid.org/0000-0002-9375-5992
authorships[7].author.display_name	Shiyi Zhang
authorships[7].countries	CN
authorships[7].affiliations[0].institution_ids	https://openalex.org/I183067930
authorships[7].affiliations[0].raw_affiliation_string	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
authorships[7].institutions[0].id	https://openalex.org/I183067930
authorships[7].institutions[0].ror	https://ror.org/0220qvk04
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I183067930
authorships[7].institutions[0].country_code	CN
authorships[7].institutions[0].display_name	Shanghai Jiao Tong University
authorships[7].author_position	last
authorships[7].raw_author_name	Shiyi Zhang
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	School of Pharmacy and School of Biomedical Engineering, Shanghai Jiao Tong University, 200240, Shanghai, China
has_content.pdf	False
has_content.grobid_xml	False
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.ncbi.nlm.nih.gov/pmc/articles/9902485
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Capecitabine induces hand-foot syndrome through elevated thymidine phosphorylase-mediated locoregional toxicity and GSDME-driven pyroptosis that can be relieved by tipiracil
has_fulltext	False
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T12937
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	1.0
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2708
primary_topic.subfield.display_name	Dermatology
primary_topic.display_name	Chemotherapy-related skin toxicity
related_works	https://openalex.org/W2387874833, https://openalex.org/W2381322183, https://openalex.org/W2365250332, https://openalex.org/W1956578949, https://openalex.org/W2048287147, https://openalex.org/W2373338389, https://openalex.org/W3103719647, https://openalex.org/W2102433244, https://openalex.org/W2181322113, https://openalex.org/W2011892983
cited_by_count	16
counts_by_year[0].year	2025
counts_by_year[0].cited_by_count	7
counts_by_year[1].year	2024
counts_by_year[1].cited_by_count	7
counts_by_year[2].year	2023
counts_by_year[2].cited_by_count	2
locations_count	3
best_oa_location.id	pmh:oai:pubmedcentral.nih.gov:9902485
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S2764455111
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	PubMed Central
best_oa_location.source.host_organization	https://openalex.org/I1299303238
best_oa_location.source.host_organization_name	National Institutes of Health
best_oa_location.source.host_organization_lineage	https://openalex.org/I1299303238
best_oa_location.license
best_oa_location.pdf_url
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	Text
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name	Br J Cancer
best_oa_location.landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/9902485
primary_location.id	doi:10.1038/s41416-022-02039-3
primary_location.is_oa	False
primary_location.source.id	https://openalex.org/S62966998
primary_location.source.issn	0007-0920, 1532-1827
primary_location.source.type	journal
primary_location.source.is_oa	False
primary_location.source.issn_l	0007-0920
primary_location.source.is_core	True
primary_location.source.is_in_doaj	False
primary_location.source.display_name	British Journal of Cancer
primary_location.source.host_organization	https://openalex.org/P4310319965
primary_location.source.host_organization_name	Springer Nature
primary_location.source.host_organization_lineage	https://openalex.org/P4310319965
primary_location.license
primary_location.pdf_url
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	British Journal of Cancer
primary_location.landing_page_url	https://doi.org/10.1038/s41416-022-02039-3
publication_date	2022-11-08
publication_year	2022
referenced_works	https://openalex.org/W2087675944, https://openalex.org/W2078221442, https://openalex.org/W2001123286, https://openalex.org/W42253793, https://openalex.org/W1979186680, https://openalex.org/W2153625933, https://openalex.org/W2191413197, https://openalex.org/W2140626944, https://openalex.org/W1966574632, https://openalex.org/W2144791212, https://openalex.org/W2050684119, https://openalex.org/W6662830976, https://openalex.org/W2091951404, https://openalex.org/W2156497634, https://openalex.org/W2516657632, https://openalex.org/W2092325910, https://openalex.org/W2044970916, https://openalex.org/W2055568666, https://openalex.org/W6664565554, https://openalex.org/W1986952772, https://openalex.org/W2055562862, https://openalex.org/W2069648355, https://openalex.org/W2058130490, https://openalex.org/W6664939750, https://openalex.org/W2094755494, https://openalex.org/W2093963262, https://openalex.org/W2108300681, https://openalex.org/W3157776632, https://openalex.org/W3003771615, https://openalex.org/W2911937431, https://openalex.org/W2608687752, https://openalex.org/W2770936091, https://openalex.org/W3142080073, https://openalex.org/W3168373164, https://openalex.org/W2606696407, https://openalex.org/W2304527713, https://openalex.org/W2152676488, https://openalex.org/W1985658064, https://openalex.org/W2059292387, https://openalex.org/W3011500848, https://openalex.org/W2076687077, https://openalex.org/W2155769979, https://openalex.org/W2189078621, https://openalex.org/W6687351831, https://openalex.org/W2062611780, https://openalex.org/W2818139375
referenced_works_count	46
abstract_inverted_index
cited_by_percentile_year.max	99
cited_by_percentile_year.min	94
countries_distinct_count	1
institutions_distinct_count	8
citation_normalized_percentile.value	0.92781104
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True