CAPN2: A Target Enabling Package Article Swipe
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Xiaodong Wang
,
Michael A. Stashko
,
Shiva Krishna Reddy Guduru
,
Marta Glavatskikh
,
Dmitri Kireev
,
Ken Pearce
,
Stephen V. Frye
,
W.J. Bradshaw
,
Paul E. Brennan
,
Yuhong Fu
,
Haian Fu
,
Emory-Sage-SGC TREAT-AD Center
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5281/zenodo.5903022
· OA: W4393477466
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.5281/zenodo.5903022
· OA: W4393477466
CAPN2 mediates neurodegenerative effect through cleavage of a range of proteins linked to tau hyperphosphorylation (GSK-3β), higher levels of Aβ (NCX3), or poor memory (CPEB3). Inhibiting calpain-2 might reduce cleavage of these proteins and reverse its neurodegenerative effect. This aim of this TEP is to produce reagents to allow for further analysis of CAPN2 as a potential target for AD treatment.
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