Carbohydrate-Based Host-Guest Complexation of Hydrophobic Antibiotics for the Enhancement of Antibacterial Activity Article Swipe
Daham Jeong
,
Sang‐Woo Joo
,
Vijay Vilas Shinde
,
Eunae Cho
,
Seunho Jung
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3390/molecules22081311
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.3390/molecules22081311
Host-guest complexation with various hydrophobic drugs has been used to enhance the solubility, permeability, and stability of guest drugs. Physical changes in hydrophobic drugs by complexation have been related to corresponding increases in the bioavailability of these drugs. Carbohydrates, including various derivatives of cyclodextrins, cyclosophoraoses, and some linear oligosaccharides, are generally used as host complexation agents in drug delivery systems. Many antibiotics with low bioavailability have some limitations to their clinical use due to their intrinsically poor aqueous solubility. Bioavailability enhancement is therefore an important step to achieve the desired concentration of antibiotics in the treatment of bacterial infections. Antibiotics encapsulated in a complexation-based drug delivery system will display improved antibacterial activity making it possible to reduce dosages and overcome the serious global problem of antibiotic resistance. Here, we review the present research trends in carbohydrate-based host-guest complexation of various hydrophobic antibiotics as an efficient delivery system to improve solubility, permeability, stability, and controlled release.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/molecules22081311
- https://www.mdpi.com/1420-3049/22/8/1311/pdf?version=1502194174
- OA Status
- gold
- Cited By
- 24
- References
- 112
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2744064885
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2744064885Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/molecules22081311Digital Object Identifier
- Title
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Carbohydrate-Based Host-Guest Complexation of Hydrophobic Antibiotics for the Enhancement of Antibacterial ActivityWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-08-08Full publication date if available
- Authors
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Daham Jeong, Sang‐Woo Joo, Vijay Vilas Shinde, Eunae Cho, Seunho JungList of authors in order
- Landing page
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https://doi.org/10.3390/molecules22081311Publisher landing page
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https://www.mdpi.com/1420-3049/22/8/1311/pdf?version=1502194174Direct link to full text PDF
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
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https://www.mdpi.com/1420-3049/22/8/1311/pdf?version=1502194174Direct OA link when available
- Concepts
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Bioavailability, Chemistry, Solubility, Antibiotics, Drug delivery, Drug, Combinatorial chemistry, Aqueous solution, Hydrophobic effect, Organic chemistry, Pharmacology, Biochemistry, MedicineTop concepts (fields/topics) attached by OpenAlex
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24Total citation count in OpenAlex
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2025: 1, 2024: 4, 2023: 3, 2022: 2, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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112Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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