Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery disease Article Swipe
H. Hämäläinen
,
Tiina M. Laitinen
,
Marja Hedman
,
Antti Hedman
,
Antti Kivelä
,
Tomi Laitinen
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/cpf.12780
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1111/cpf.12780
Background In patients with coronary artery disease (CAD), ischaemic cardiomyopathy may result in progressive cardiac remodelling and left ventricular (LV) dysfunction. Myocardial perfusion imaging (MPI) can be used to quantify LV size and shape, mechanical dyssynchrony (LVMD) and ejection fraction (EF) as well as myocardial ischaemia and injury extents. We investigated the prevalence of LV remodelling (LVR) in patients with CAD and the relationship between LVR, LVMD and EF. Methods Three hundred twenty‐six patients with CAD were evaluated. The EF and end‐diastolic volume (EDV) were measured using MPI. LVMD was assessed using phase analysis. LVR was characterised according to LV dilatation or increased shape indices (systolic shape index [SIES] and diastolic shape index [SIED]). Results LVR were observed in 41% of CAD patients. EDV, SIES and SIED were larger in patients with LVMD or low EF. After adjustment for age, sex and infarct and ischaemia extents, phase histogram bandwidth correlated with EDV ( r = 0.218) and SIES ( r = 0.266) and EF correlated with EDV ( r = –0.535), SIES ( r = –0.554) and SIED ( r = –0.217, p < 0.001 for all). Conclusions LVR is frequently seen in patients with CAD and may be detected even before the development of symptomatic heart failure. A large LV volume and a more spherical‐shaped LV were associated with LVMD and low EF, highlighting the close relationships between remodelling and systolic dyssynchrony and dysfunction. MPI is useful for assessing LVR by providing information about LV size and shape, which changes from an ellipsoid towards a spherical form in the development of ischaemic cardiomyopathy.
Related Topics
Concepts
Medicine
Cardiology
Internal medicine
Ejection fraction
Coronary artery disease
Heart failure
Gated SPECT
Myocardial perfusion imaging
Ventricular remodeling
Diastole
Ventricular dyssynchrony
Ischemia
Cardiac resynchronization therapy
Blood pressure
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/cpf.12780
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpf.12780
- OA Status
- bronze
- Cited By
- 8
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285730877
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285730877Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/cpf.12780Digital Object Identifier
- Title
-
Cardiac remodelling in association with left ventricular dyssynchrony and systolic dysfunction in patients with coronary artery diseaseWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-07-18Full publication date if available
- Authors
-
H. Hämäläinen, Tiina M. Laitinen, Marja Hedman, Antti Hedman, Antti Kivelä, Tomi LaitinenList of authors in order
- Landing page
-
https://doi.org/10.1111/cpf.12780Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpf.12780Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cpf.12780Direct OA link when available
- Concepts
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Medicine, Cardiology, Internal medicine, Ejection fraction, Coronary artery disease, Heart failure, Gated SPECT, Myocardial perfusion imaging, Ventricular remodeling, Diastole, Ventricular dyssynchrony, Ischemia, Cardiac resynchronization therapy, Blood pressureTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
8Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 4, 2023: 2, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
28Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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