Cardiac time intervals and myocardial performance index for prediction of twin–twin transfusion syndrome Article Swipe

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Manon Gijtenbeek , Sanne J. Eschbach , Jaap M. Middeldorp , Frans J.C.M. Klumper , Femke Slaghekke , Dick Oepkes , Monique C. Haak ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.1002/pd.5981

Objectives To explore whether intertwin discordance in myocardial performance index (MPI) or cardiac time intervals enables the prediction of twin–twin transfusion syndrome (TTTS) in monochorionic diamniotic (MCDA) pregnancies with amniotic fluid discordance. Methods Prospective cohort study of MCDA pregnancies with amniotic fluid discordance ≥4 cm. Serial ultrasound examinations consisted of evaluation of amniotic fluid, fetal Dopplers and fetal cardiac function. Results We included 21 “future‐TTTS” (group I), 18 selective fetal growth restriction (sFGR; group II) and 20 uncomplicated MCDA twin pairs (group III). Group I had a higher intertwin difference in left ventricle (LV) MPI and right ventricle (RV) MPI compared to group II and III. The intertwin difference in global heart relaxation time was significantly higher in group I compared to group III. Future recipient twins had significantly higher contraction times of the global heart and RV and lower relaxation times of the global heart and RV compared to the “expected recipients” in group II and III. Conclusion Intertwin discordance in LV‐MPI and RV‐MPI differentiate between TTTS and MCDA pregnancies with transient discordant amniotic fluid volume. Cardiac time intervals identify future recipient twins. The clinical utility of cardiac time intervals and MPI should be investigated in large prospective studies.

Related Topics

Intrauterine Growth Restriction

Pregnancy

Fetus

Biology

Concepts

Medicine Ventricle Amniotic fluid Amniotic fluid index Internal medicine Cardiology Prospective cohort study Twin-to-twin transfusion syndrome Obstetrics Intrauterine growth restriction Pregnancy Fetus Biology Genetics

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Type: article
Language: en
Landing Page: https://doi.org/10.1002/pd.5981
PDF: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pd.5981
OA Status: hybrid
Cited By: 6
References: 21
Related Works: 10
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DOI: https://doi.org/10.1002/pd.5981

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Title: Cardiac time intervals and myocardial performance index for prediction of twin–twin transfusion syndrome

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Type: article

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Language: en

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Publication year: 2021

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Publication date: 2021-06-09

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Authors: Manon Gijtenbeek, Sanne J. Eschbach, Jaap M. Middeldorp, Frans J.C.M. Klumper, Femke Slaghekke, Dick Oepkes, Monique C. Haak

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Landing page: https://doi.org/10.1002/pd.5981

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Concepts: Medicine, Ventricle, Amniotic fluid, Amniotic fluid index, Internal medicine, Cardiology, Prospective cohort study, Twin-to-twin transfusion syndrome, Obstetrics, Intrauterine growth restriction, Pregnancy, Fetus, Biology, Genetics

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Cited by: 6

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