Cardio-oncology guidelines, structural heart disease and Kounis syndrome in the upcoming guidelines Article Swipe
Miguel Nobre Menezes
,
Mauricio Hostim Silva
,
Andreia Magalhães
,
Bruno Melica
,
Júlia Cristina Toste
,
Rita Calé
,
Manuel Almeida
,
Manuela Fiúza
,
Eduardo Infante de Oliveira
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.repc.2024.03.003
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.repc.2024.03.003
Cardio-oncology guidelines, structural heart disease and Kounis syndrome in the upcoming guidelines Recomendac ¸ões de cardio-oncologia, doenc ¸a cardíaca estrutural e síndrome de Kounis nas próximas recomendac ¸õesThe Cardio-Oncology Study Group of the Portuguese Society of Cardiology and the Portuguese Association of Cardiovascular Intervention have collaborated to produce a position paper that addresses the topic of cardiac intervention in cancer patients, with an emphasis on percutaneous techniques. 1 The authors of this outstanding work underlined the scarcity of currently available evidence or recommendations for treating structural or coronary heart disease.Another important point to remember is that, possibly more so than in the general population, the manifestations of coronary artery disease in cancer patients are frequently caused by microvascular disease, classical atherosclerotic disease, vasospasm and hypersensitivity to cancer drugs leading to hypersensitivity-associated acute coronary syndrome, so-called Kounis syndrome (KS). 2 Furthermore, this subject is only touched upon in passing in the most recent (2022) European Society of Cardiology (ESC) guidelines on cardio-oncology, 3 for which the ESC collaborated with the European Hematology Association, the European Society for Therapeutic Radiology and Oncology, and the International Cardio-Oncology Society.However, a noteworthy omission from the ESC guidelines is hypersensitivity reactions and the Kounis hypersensitivity-associated coronary syndrome, despite the fact that these conditions have been identified as serious side effects of cancer therapy in many reports in the medical literature.KS is an acute coronary syndrome that results from hypersensitivity or anaphylactic reactions.It can manifest as vasospastic angina (type 1), myocardial infarction (type 2), stent thrombosis with an occluding thrombus (type 3A), or stent restenosis (type 3B).Mast cells, which are best known for inducing hypersensitivity, are found in cardiac tissue and especially in the vulnerable shoulder region of atheroma of coronary arteries. 4uring the hypersensitivity reaction, inflammatory mediators are released, with effects including vasoconstriction and coronary artery spasm facilitated by histamine, platelet-activating factor, and eicosanoids.In the US
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- Type
- letter
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.repc.2024.03.003
- OA Status
- diamond
- Cited By
- 1
- References
- 9
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4400105691
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4400105691Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.repc.2024.03.003Digital Object Identifier
- Title
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Cardio-oncology guidelines, structural heart disease and Kounis syndrome in the upcoming guidelinesWork title
- Type
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letterOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-06-01Full publication date if available
- Authors
-
Miguel Nobre Menezes, Mauricio Hostim Silva, Andreia Magalhães, Bruno Melica, Júlia Cristina Toste, Rita Calé, Manuel Almeida, Manuela Fiúza, Eduardo Infante de OliveiraList of authors in order
- Landing page
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https://doi.org/10.1016/j.repc.2024.03.003Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.repc.2024.03.003Direct OA link when available
- Concepts
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Kounis syndrome, Medicine, Internal medicine, Cardiology, Disease, Oncology, Intensive care medicine, Acute coronary syndrome, Myocardial infarctionTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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9Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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