Cardioprotective effects of short-term empagliflozin treatment in db/db mice Article Swipe
Bernhard Radlinger
,
Florian Hornsteiner
,
Sabrina Folie
,
Willi Salvenmoser
,
Bernhard J. Haubner
,
Thomas Schuetz
,
Simone Haas
,
Claudia Ress
,
Timon E. Adolph
,
Karin Salzmann
,
Bernhard G. Weiss
,
Herbert Tilg
,
Susanne Kaser
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-020-76698-8
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-020-76698-8
Sodium glucose transporter (SGLT)-2 inhibitors have consistently shown cardioprotective effects independent of the glycemic status of treated patients. In this study we aimed to investigate underlying mechanisms of short-term empagliflozin treatment in a mouse model of type II diabetes. Male db/db mice were fed a western type diet with or without enrichment with empagliflozin for 7 days. While glucose tolerance was significantly improved in empagliflozin treated mice, body weight and fasting insulin levels were comparable in both groups. Cardiac insulin signaling activity indicated by reduced proteinkinase B (AKT) phosphorylation was significantly decreased in the empagliflozin treated group. Remarkably, mitochondrial mass estimated by citrate synthase activity was significantly elevated in empagliflozin treated mice. Accordingly, mitochondrial morphology was significantly altered upon treatment with empagliflozin as analysed by transmission electron microscopy. Additionally, short-term empagliflozin therapy was associated with a changed cardiac tissue cytokine expression in favor of an anti-inflammatory pattern. Our data suggest that early cardioprotection in empagliflozin treated mice is independent of a reduction in body weight or hyperinsulinemia. Ameliorated mitochondrial ultrastructure, attenuated cardiac insulin signaling and diminished cardiac inflammation might contribute to the cardioprotective effects of empagliflozin.
Related Topics
Concepts
Empagliflozin
Endocrinology
Insulin
Medicine
Type 2 diabetes
Internal medicine
Pharmacology
Glycemic
Canagliflozin
Cardioprotection
Diabetes mellitus
Myocardial infarction
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-020-76698-8
- https://www.nature.com/articles/s41598-020-76698-8.pdf
- OA Status
- gold
- Cited By
- 24
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3102806899
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3102806899Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-020-76698-8Digital Object Identifier
- Title
-
Cardioprotective effects of short-term empagliflozin treatment in db/db miceWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-11-12Full publication date if available
- Authors
-
Bernhard Radlinger, Florian Hornsteiner, Sabrina Folie, Willi Salvenmoser, Bernhard J. Haubner, Thomas Schuetz, Simone Haas, Claudia Ress, Timon E. Adolph, Karin Salzmann, Bernhard G. Weiss, Herbert Tilg, Susanne KaserList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-020-76698-8Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-020-76698-8.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41598-020-76698-8.pdfDirect OA link when available
- Concepts
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Empagliflozin, Endocrinology, Insulin, Medicine, Type 2 diabetes, Internal medicine, Pharmacology, Glycemic, Canagliflozin, Cardioprotection, Diabetes mellitus, Myocardial infarctionTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
24Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 5, 2023: 3, 2022: 6, 2021: 5Per-year citation counts (last 5 years)
- References (count)
-
49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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