Cardiovascular risks and primary interventions among treated rheumatoid arthritis patients: Experience from a tertiary care centre in Kuala Lumpur, Malaysia Article Swipe

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Shantini Radhakrishnan , Salmi Abdul Razak , Mohd Shahrir Mohamed Said , Noraida Mohamed Shah , Adyani Md Redzuan ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.4314/tjpr.v21i4.25

Purpose: To investigate the cardiovascular risk among treated rheumatoid arthritis (RA) patients to predict the factors associated with high cardiovascular risk and to determine the presence of pharmacotherapy primary prevention among treated RA patients with high cardiovascular disease (CVD) risk.Methods: The study was a prospective cross-sectional study on adult patients diagnosed and treated for RA and without established heart disease/stroke. Cardiovascular risk scoring was based on Framingham Cardiovascular Disease 10-year risk prediction model (BMI model) x 1.5 factor while descriptive and inferential analyses were done using SPSS.Results: High CVD risk was defined as FRS-CVD cardiovascular risk categories (>20%) and 55.9% of patients were at high CVD risk. Use of Hydroxychloroquine (OR: 0.44; 95 % CI: 0.21- 0.92; p= 0.028) and COX-2 inhibitors (OR: 0.31; 95% CI:0.10- 0.95; p = 0.039) were found to be significantly associated with high CVD risk among treated RA patients. Significant number of high CVD risk patients did receive pharmacotherapy primary prevention (p = 0.001).Conclusion: Hydroxychloroquine and COX-2 inhibitors are independent negative risk predictors associated with high CVD risk among treated RA patients. Baseline cardiovascular risk data may be useful in rational use of medications to treat RA, considering that cardiovascular related mortality is the leading cause of death in RA.

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Infectious Diseases (Medical Specialty)

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Medicine Internal medicine Rheumatoid arthritis Framingham Risk Score Hydroxychloroquine Disease Pharmacotherapy Risk factor Proportional hazards model Infectious disease (medical specialty) Coronavirus disease 2019 (COVID-19)

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Type: article
Language: en
Landing Page: https://doi.org/10.4314/tjpr.v21i4.25
PDF: https://www.ajol.info/index.php/tjpr/article/download/226218/213486
OA Status: gold
Cited By: 1
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DOI: https://doi.org/10.4314/tjpr.v21i4.25

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Title: Cardiovascular risks and primary interventions among treated rheumatoid arthritis patients: Experience from a tertiary care centre in Kuala Lumpur, Malaysia

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Language: en

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Publication year: 2022

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Publication date: 2022-06-04

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Authors: Shantini Radhakrishnan, Salmi Abdul Razak, Mohd Shahrir Mohamed Said, Noraida Mohamed Shah, Adyani Md Redzuan

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Landing page: https://doi.org/10.4314/tjpr.v21i4.25

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Concepts: Medicine, Internal medicine, Rheumatoid arthritis, Framingham Risk Score, Hydroxychloroquine, Disease, Pharmacotherapy, Risk factor, Proportional hazards model, Infectious disease (medical specialty), Coronavirus disease 2019 (COVID-19)

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Cited by: 1

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abstract_inverted_index.useful	183
abstract_inverted_index.10-year	69
abstract_inverted_index.Disease	68
abstract_inverted_index.FRS-CVD	93
abstract_inverted_index.defined	91
abstract_inverted_index.disease	37
abstract_inverted_index.factors	15
abstract_inverted_index.leading	199
abstract_inverted_index.predict	13
abstract_inverted_index.primary	28, 154
abstract_inverted_index.receive	152
abstract_inverted_index.related	195
abstract_inverted_index.scoring	62
abstract_inverted_index.treated	7, 31, 52, 141, 174
abstract_inverted_index.without	56
abstract_inverted_index.Baseline	177
abstract_inverted_index.CI:0.10-	125
abstract_inverted_index.Purpose:	0
abstract_inverted_index.analyses	82
abstract_inverted_index.negative	165
abstract_inverted_index.patients	11, 33, 49, 101, 150
abstract_inverted_index.presence	25
abstract_inverted_index.rational	185
abstract_inverted_index.(>20%)	97
abstract_inverted_index.arthritis	9
abstract_inverted_index.determine	23
abstract_inverted_index.diagnosed	50
abstract_inverted_index.mortality	196
abstract_inverted_index.patients.	143, 176
abstract_inverted_index.Framingham	66
abstract_inverted_index.associated	16, 135, 168
abstract_inverted_index.categories	96
abstract_inverted_index.inhibitors	121, 162
abstract_inverted_index.prediction	71
abstract_inverted_index.predictors	167
abstract_inverted_index.prevention	29, 155
abstract_inverted_index.rheumatoid	8
abstract_inverted_index.Significant	144
abstract_inverted_index.considering	192
abstract_inverted_index.descriptive	79
abstract_inverted_index.established	57
abstract_inverted_index.independent	164
abstract_inverted_index.inferential	81
abstract_inverted_index.investigate	2
abstract_inverted_index.medications	188
abstract_inverted_index.prospective	44
abstract_inverted_index.SPSS.Results:	86
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abstract_inverted_index.Cardiovascular	60, 67
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abstract_inverted_index.cross-sectional	45
abstract_inverted_index.disease/stroke.	59
abstract_inverted_index.pharmacotherapy	27, 153
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institutions_distinct_count	5
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