Carotid Ultrasonography as a Strategy to Optimize the Management of Cardiovascular Risk in Patients with Type 1 Diabetes: A Cohort Study Article Swipe
Laura Boswell
,
Tonet Serés‐Noriega
,
Alex Mesa
,
Verónica Perea
,
Adriana Pané
,
Clara Viñals
,
Jesús Blanco
,
Marga Giménez
,
Irene Vinagre
,
Enric Esmatjes
,
Ignacio Conget
,
Antonio J. Amor
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1015404/v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-1015404/v1
Background : Although cardiovascular disease (CVD) remains the leading cause of mortality in type 1 diabetes (T1D), the use of cardioprotective drugs is scarce. We aimed to evaluate the impact of carotid ultrasonography (US) on the improvement in cardiovascular risk factors (CVRFs) in T1D. Methods : T1D patients without CVD meeting criteria for lipid treatment according to guidelines (age ≥40 years, nephropathy and/or ≥10 years of diabetes duration with ≥1 additional CVRFs) were included. The carotid-US group (US-G) underwent a standardized US protocol and CVRF assessment; recommendations were made according to subclinical atherosclerosis status. The control group (CG) followed usual clinical practice. Changes in CVRFs, specially statin use and LDL-cholesterol levels, at one year were analysed. Results: A total of 318 patients were included (51.3% female, mean age of 49.1 years and 25.5 years of diabetes duration): 211 in the US-G and 107 in the CG. Participants in the US-G had a higher baseline LDL-cholesterol than controls (114 vs. 102 mg/dL; p<0.001). Lipid-lowering treatment was modified in 38.9% in the US-G and 6.5% in the CG (p<0.001). At 1 year, the US-G was more frequently on statins, had lower LDL-cholesterol and 27% had stopped smoking (p<0.001 for all). Changes were more pronounced in those with plaques (p<0.001). In multivariate analyses adjusted for age, sex and other CVRFs, belonging to the US-G was independently associated with the intensification of lipid-lowering treatment (OR 10.47 [4.06-27.01]). Conclusions: Carotid-US is independently associated with an intensification of lipid-lowering therapy in a high-risk T1D population.
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Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-1015404/v1
- https://www.researchsquare.com/article/rs-1015404/latest.pdf
- OA Status
- green
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3209103414
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3209103414Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-1015404/v1Digital Object Identifier
- Title
-
Carotid Ultrasonography as a Strategy to Optimize the Management of Cardiovascular Risk in Patients with Type 1 Diabetes: A Cohort StudyWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-10-28Full publication date if available
- Authors
-
Laura Boswell, Tonet Serés‐Noriega, Alex Mesa, Verónica Perea, Adriana Pané, Clara Viñals, Jesús Blanco, Marga Giménez, Irene Vinagre, Enric Esmatjes, Ignacio Conget, Antonio J. AmorList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-1015404/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-1015404/latest.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.researchsquare.com/article/rs-1015404/latest.pdfDirect OA link when available
- Concepts
-
Type 2 diabetes, Medicine, Ultrasonography, Cohort, Carotid ultrasonography, Diabetes mellitus, Internal medicine, Carotid arteries, Cardiology, Radiology, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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