Case report: a rare clinical presentation of a difficult diagnosis of dedifferentiated liposarcoma showing leiomyosarcoma phenotype in the ileocecal region Article Swipe
Tomonori Kawasaki
,
Tomoaki Tashima
,
Kojiro Onohara
,
Yasumitsu Hirano
,
Misuzu Yamato
,
Suguru Shirotake
,
Tomoaki Torigoe
,
Yasuo Yazawa
,
Masataka Hirasaki
,
Masanori Wako
,
Taro Fujimaki
,
Jiro Ichikawa
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1425809
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2024.1425809
Dedifferentiated liposarcoma is a malignant lipomatous tumor that rarely occurs in the gastrointestinal tract, including the ileocecal region. In this case, computed tomography and magnetic resonance imaging showed no fatty mass located in the mesenteric or submucosal lesion, and positron emission tomography–computed tomography showed a high maximum standardized uptake value, collectively indicating the gastrointestinal stroma tumor and lymphoma. The pathological findings resemble leiomyosarcoma; the immunohistochemistry findings including mouse double minute 2 homolog and cyclin D-dependent kinase-4 and amplification of mouse double minute 2 homolog in fluorescence in situ hybridization just favored the diagnosis of dedifferentiated liposarcoma with leiomyosarcoma phenotype and not leiomyosarcoma. Recently, a new inhibitor for mouse double minute 2 homolog and cyclin D-dependent kinase-4 has been developed, and clinical trials for dedifferentiated liposarcoma are currently ongoing. This could change the treatment strategy drastically compared with other soft tissue sarcomas. Hence, a correct diagnosis of dedifferentiated liposarcoma is required.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2024.1425809
- OA Status
- gold
- Cited By
- 5
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404219751
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404219751Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2024.1425809Digital Object Identifier
- Title
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Case report: a rare clinical presentation of a difficult diagnosis of dedifferentiated liposarcoma showing leiomyosarcoma phenotype in the ileocecal regionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-11Full publication date if available
- Authors
-
Tomonori Kawasaki, Tomoaki Tashima, Kojiro Onohara, Yasumitsu Hirano, Misuzu Yamato, Suguru Shirotake, Tomoaki Torigoe, Yasuo Yazawa, Masataka Hirasaki, Masanori Wako, Taro Fujimaki, Jiro IchikawaList of authors in order
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https://doi.org/10.3389/fonc.2024.1425809Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fonc.2024.1425809Direct OA link when available
- Concepts
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Presentation (obstetrics), Liposarcoma, Leiomyosarcoma, Medicine, Case presentation, Phenotype, Pathology, Radiology, Sarcoma, Biology, Surgery, Gene, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5Per-year citation counts (last 5 years)
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18Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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