Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling Article Swipe
Adrienn Skopál
,
Tamás Kéki
,
Péter Tóth
,
Balázs Csóka
,
Balázs Koscsó
,
Zoltán H. Németh
,
Luca Antonioli
,
Andreas Ivessa
,
Francisco Ciruela
,
László Virág
,
György Haskó
,
Endre Kókai
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.jbc.2022.101888
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.jbc.2022.101888
Adenosine A2A receptor (A2AR)-dependent signaling in macrophages plays a key role in the regulation of inflammation. However, the processes regulating A2AR targeting to the cell surface and degradation in macrophages are incompletely understood. For example, the C-terminal domain of the A2AR and proteins interacting with it are known to regulate receptor recycling, although it is unclear what role potential A2AR-interacting partners have in macrophages. Here, we aimed to identify A2AR-interacting partners in macrophages that may effect receptor trafficking and activity. To this end, we performed a yeast two-hybrid screen using the C-terminal tail of A2AR as the "bait" and a macrophage expression library as the "prey." We found that the lysosomal protease cathepsin D (CtsD) was a robust hit. The A2AR-CtsD interaction was validated in vitro and in cellular models, including RAW 264.7 and mouse peritoneal macrophage (IPMΦ) cells. We also demonstrated that the A2AR is a substrate of CtsD and that the blockade of CtsD activity increases the density and cell surface targeting of A2AR in macrophages. Conversely, we demonstrate that A2AR activation prompts the maturation and enzymatic activity of CtsD in macrophages. In summary, we conclude that CtsD is a novel A2AR-interacting partner and thus describe molecular and functional interplay that may be crucial for adenosine-mediated macrophage regulation in inflammatory processes.
Related Topics
Concepts
Cell biology
Adenosine A2A receptor
Receptor
Cathepsin
Macrophage
Biology
Chemistry
Adenosine receptor
In vitro
Biochemistry
Enzyme
Agonist
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jbc.2022.101888
- http://www.jbc.org/article/S0021925822003283/pdf
- OA Status
- gold
- Cited By
- 9
- References
- 64
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4220845199
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4220845199Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.jbc.2022.101888Digital Object Identifier
- Title
-
Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signalingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-03-31Full publication date if available
- Authors
-
Adrienn Skopál, Tamás Kéki, Péter Tóth, Balázs Csóka, Balázs Koscsó, Zoltán H. Németh, Luca Antonioli, Andreas Ivessa, Francisco Ciruela, László Virág, György Haskó, Endre KókaiList of authors in order
- Landing page
-
https://doi.org/10.1016/j.jbc.2022.101888Publisher landing page
- PDF URL
-
https://www.jbc.org/article/S0021925822003283/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.jbc.org/article/S0021925822003283/pdfDirect OA link when available
- Concepts
-
Cell biology, Adenosine A2A receptor, Receptor, Cathepsin, Macrophage, Biology, Chemistry, Adenosine receptor, In vitro, Biochemistry, Enzyme, AgonistTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 4, 2023: 2Per-year citation counts (last 5 years)
- References (count)
-
64Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4220845199 |
|---|---|
| doi | https://doi.org/10.1016/j.jbc.2022.101888 |
| ids.doi | https://doi.org/10.1016/j.jbc.2022.101888 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35367412 |
| ids.openalex | https://openalex.org/W4220845199 |
| fwci | 1.80435592 |
| mesh[0].qualifier_ui | Q000378 |
| mesh[0].descriptor_ui | D000241 |
| mesh[0].is_major_topic | True |
| mesh[0].qualifier_name | metabolism |
| mesh[0].descriptor_name | Adenosine |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000818 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Animals |
| mesh[2].qualifier_ui | Q000378 |
| mesh[2].descriptor_ui | D002352 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | metabolism |
| mesh[2].descriptor_name | Carrier Proteins |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D002402 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | Cathepsin D |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D002402 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Cathepsin D |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D008264 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Macrophages |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D051379 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Mice |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D043705 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | Receptor, Adenosine A2A |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D043705 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Receptor, Adenosine A2A |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D015398 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Signal Transduction |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D000241 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Adenosine |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D000818 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Animals |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D002352 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Carrier Proteins |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D002402 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Cathepsin D |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D002402 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Cathepsin D |
| mesh[15].qualifier_ui | Q000378 |
| mesh[15].descriptor_ui | D008264 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | metabolism |
| mesh[15].descriptor_name | Macrophages |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D051379 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Mice |
| mesh[17].qualifier_ui | Q000235 |
| mesh[17].descriptor_ui | D043705 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | genetics |
| mesh[17].descriptor_name | Receptor, Adenosine A2A |
| mesh[18].qualifier_ui | Q000378 |
| mesh[18].descriptor_ui | D043705 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | metabolism |
| mesh[18].descriptor_name | Receptor, Adenosine A2A |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D015398 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Signal Transduction |
| type | article |
| title | Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling |
| awards[0].id | https://openalex.org/G5617736667 |
| awards[0].funder_id | https://openalex.org/F4320336675 |
| awards[0].display_name | |
| awards[0].funder_award_id | GINOP-2.3.2-15-2016-00020 |
| awards[0].funder_display_name | National Research, Development and Innovation Office |
| awards[1].id | https://openalex.org/G1872091918 |
| awards[1].funder_id | https://openalex.org/F4320321994 |
| awards[1].display_name | |
| awards[1].funder_award_id | MB08A 84685 |
| awards[1].funder_display_name | Hungarian Scientific Research Fund |
| awards[2].id | https://openalex.org/G1303723287 |
| awards[2].funder_id | https://openalex.org/F4320332161 |
| awards[2].display_name | |
| awards[2].funder_award_id | PID2020-118511RB-I00 |
| awards[2].funder_display_name | National Institutes of Health |
| awards[3].id | https://openalex.org/G3014707195 |
| awards[3].funder_id | https://openalex.org/F4320336675 |
| awards[3].display_name | |
| awards[3].funder_award_id | GINOP-2.3.2-15-2016-00048 |
| awards[3].funder_display_name | National Research, Development and Innovation Office |
| awards[4].id | https://openalex.org/G8329538458 |
| awards[4].funder_id | https://openalex.org/F4320332161 |
| awards[4].display_name | |
| awards[4].funder_award_id | R01DK113790 |
| awards[4].funder_display_name | National Institutes of Health |
| awards[5].id | https://openalex.org/G3156314389 |
| awards[5].funder_id | https://openalex.org/F4320332161 |
| awards[5].display_name | |
| awards[5].funder_award_id | MCIN/AEI/10.13039/501100011033 |
| awards[5].funder_display_name | National Institutes of Health |
| awards[6].id | https://openalex.org/G4090616718 |
| awards[6].funder_id | https://openalex.org/F4320332161 |
| awards[6].display_name | |
| awards[6].funder_award_id | R01GM066189 |
| awards[6].funder_display_name | National Institutes of Health |
| awards[7].id | https://openalex.org/G7247689756 |
| awards[7].funder_id | https://openalex.org/F4320332161 |
| awards[7].display_name | |
| awards[7].funder_award_id | R01HL158519 |
| awards[7].funder_display_name | National Institutes of Health |
| awards[8].id | https://openalex.org/G372615831 |
| awards[8].funder_id | https://openalex.org/F4320322192 |
| awards[8].display_name | |
| awards[8].funder_award_id | K132193 |
| awards[8].funder_display_name | Magyar Tudományos Akadémia |
| biblio.issue | 5 |
| biblio.volume | 298 |
| biblio.last_page | 101888 |
| biblio.first_page | 101888 |
| grants[0].funder | https://openalex.org/F4320321994 |
| grants[0].award_id | MB08A 84685 |
| grants[0].funder_display_name | Hungarian Scientific Research Fund |
| grants[1].funder | https://openalex.org/F4320322192 |
| grants[1].award_id | K132193 |
| grants[1].funder_display_name | Magyar Tudományos Akadémia |
| grants[2].funder | https://openalex.org/F4320322193 |
| grants[2].award_id | |
| grants[2].funder_display_name | Nemzeti Kutatási és Technológiai Hivatal |
| grants[3].funder | https://openalex.org/F4320332161 |
| grants[3].award_id | MCIN/AEI/10.13039/501100011033 |
| grants[3].funder_display_name | National Institutes of Health |
| grants[4].funder | https://openalex.org/F4320332161 |
| grants[4].award_id | PID2020-118511RB-I00 |
| grants[4].funder_display_name | National Institutes of Health |
| grants[5].funder | https://openalex.org/F4320332161 |
| grants[5].award_id | R01DK113790 |
| grants[5].funder_display_name | National Institutes of Health |
| grants[6].funder | https://openalex.org/F4320332161 |
| grants[6].award_id | R01GM066189 |
| grants[6].funder_display_name | National Institutes of Health |
| grants[7].funder | https://openalex.org/F4320332161 |
| grants[7].award_id | R01HL158519 |
| grants[7].funder_display_name | National Institutes of Health |
| grants[8].funder | https://openalex.org/F4320335322 |
| grants[8].award_id | |
| grants[8].funder_display_name | European Regional Development Fund |
| grants[9].funder | https://openalex.org/F4320336675 |
| grants[9].award_id | GINOP-2.3.2-15-2016-00020 |
| grants[9].funder_display_name | National Research, Development and Innovation Office |
| grants[10].funder | https://openalex.org/F4320336675 |
| grants[10].award_id | GINOP-2.3.2-15-2016-00048 |
| grants[10].funder_display_name | National Research, Development and Innovation Office |
| topics[0].id | https://openalex.org/T11193 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1314 |
| topics[0].subfield.display_name | Physiology |
| topics[0].display_name | Adenosine and Purinergic Signaling |
| topics[1].id | https://openalex.org/T11178 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9988999962806702 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1312 |
| topics[1].subfield.display_name | Molecular Biology |
| topics[1].display_name | Receptor Mechanisms and Signaling |
| topics[2].id | https://openalex.org/T11308 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9961000084877014 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Sphingolipid Metabolism and Signaling |
| funders[0].id | https://openalex.org/F4320321994 |
| funders[0].ror | https://ror.org/00v349e63 |
| funders[0].display_name | Hungarian Scientific Research Fund |
| funders[1].id | https://openalex.org/F4320322192 |
| funders[1].ror | https://ror.org/02ks8qq67 |
| funders[1].display_name | Magyar Tudományos Akadémia |
| funders[2].id | https://openalex.org/F4320322193 |
| funders[2].ror | https://ror.org/03g2am276 |
| funders[2].display_name | Nemzeti Kutatási és Technológiai Hivatal |
| funders[3].id | https://openalex.org/F4320332161 |
| funders[3].ror | https://ror.org/01cwqze88 |
| funders[3].display_name | National Institutes of Health |
| funders[4].id | https://openalex.org/F4320335322 |
| funders[4].ror | https://ror.org/00k4n6c32 |
| funders[4].display_name | European Regional Development Fund |
| funders[5].id | https://openalex.org/F4320336675 |
| funders[5].ror | |
| funders[5].display_name | National Research, Development and Innovation Office |
| is_xpac | False |
| apc_list.value | 2500 |
| apc_list.currency | USD |
| apc_list.value_usd | 2500 |
| apc_paid.value | 2190 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 2361 |
| concepts[0].id | https://openalex.org/C95444343 |
| concepts[0].level | 1 |
| concepts[0].score | 0.7489690780639648 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[0].display_name | Cell biology |
| concepts[1].id | https://openalex.org/C2778491162 |
| concepts[1].level | 5 |
| concepts[1].score | 0.5641324520111084 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q3063865 |
| concepts[1].display_name | Adenosine A2A receptor |
| concepts[2].id | https://openalex.org/C170493617 |
| concepts[2].level | 2 |
| concepts[2].score | 0.4632410407066345 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[2].display_name | Receptor |
| concepts[3].id | https://openalex.org/C167844969 |
| concepts[3].level | 3 |
| concepts[3].score | 0.44997698068618774 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q426245 |
| concepts[3].display_name | Cathepsin |
| concepts[4].id | https://openalex.org/C2779244956 |
| concepts[4].level | 3 |
| concepts[4].score | 0.4120534360408783 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q184204 |
| concepts[4].display_name | Macrophage |
| concepts[5].id | https://openalex.org/C86803240 |
| concepts[5].level | 0 |
| concepts[5].score | 0.38730621337890625 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[5].display_name | Biology |
| concepts[6].id | https://openalex.org/C185592680 |
| concepts[6].level | 0 |
| concepts[6].score | 0.36514535546302795 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[6].display_name | Chemistry |
| concepts[7].id | https://openalex.org/C67907053 |
| concepts[7].level | 4 |
| concepts[7].score | 0.2342764437198639 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q356147 |
| concepts[7].display_name | Adenosine receptor |
| concepts[8].id | https://openalex.org/C202751555 |
| concepts[8].level | 2 |
| concepts[8].score | 0.1818382441997528 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[8].display_name | In vitro |
| concepts[9].id | https://openalex.org/C55493867 |
| concepts[9].level | 1 |
| concepts[9].score | 0.15271717309951782 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[9].display_name | Biochemistry |
| concepts[10].id | https://openalex.org/C181199279 |
| concepts[10].level | 2 |
| concepts[10].score | 0.0839383602142334 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[10].display_name | Enzyme |
| concepts[11].id | https://openalex.org/C2778938600 |
| concepts[11].level | 3 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q389934 |
| concepts[11].display_name | Agonist |
| keywords[0].id | https://openalex.org/keywords/cell-biology |
| keywords[0].score | 0.7489690780639648 |
| keywords[0].display_name | Cell biology |
| keywords[1].id | https://openalex.org/keywords/adenosine-a2a-receptor |
| keywords[1].score | 0.5641324520111084 |
| keywords[1].display_name | Adenosine A2A receptor |
| keywords[2].id | https://openalex.org/keywords/receptor |
| keywords[2].score | 0.4632410407066345 |
| keywords[2].display_name | Receptor |
| keywords[3].id | https://openalex.org/keywords/cathepsin |
| keywords[3].score | 0.44997698068618774 |
| keywords[3].display_name | Cathepsin |
| keywords[4].id | https://openalex.org/keywords/macrophage |
| keywords[4].score | 0.4120534360408783 |
| keywords[4].display_name | Macrophage |
| keywords[5].id | https://openalex.org/keywords/biology |
| keywords[5].score | 0.38730621337890625 |
| keywords[5].display_name | Biology |
| keywords[6].id | https://openalex.org/keywords/chemistry |
| keywords[6].score | 0.36514535546302795 |
| keywords[6].display_name | Chemistry |
| keywords[7].id | https://openalex.org/keywords/adenosine-receptor |
| keywords[7].score | 0.2342764437198639 |
| keywords[7].display_name | Adenosine receptor |
| keywords[8].id | https://openalex.org/keywords/in-vitro |
| keywords[8].score | 0.1818382441997528 |
| keywords[8].display_name | In vitro |
| keywords[9].id | https://openalex.org/keywords/biochemistry |
| keywords[9].score | 0.15271717309951782 |
| keywords[9].display_name | Biochemistry |
| keywords[10].id | https://openalex.org/keywords/enzyme |
| keywords[10].score | 0.0839383602142334 |
| keywords[10].display_name | Enzyme |
| language | en |
| locations[0].id | doi:10.1016/j.jbc.2022.101888 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S140251998 |
| locations[0].source.issn | 0021-9258, 1067-8816, 1083-351X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 0021-9258 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Journal of Biological Chemistry |
| locations[0].source.host_organization | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_name | Elsevier BV |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320990 |
| locations[0].source.host_organization_lineage_names | Elsevier BV |
| locations[0].license | cc-by |
| locations[0].pdf_url | http://www.jbc.org/article/S0021925822003283/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Biological Chemistry |
| locations[0].landing_page_url | https://doi.org/10.1016/j.jbc.2022.101888 |
| locations[1].id | pmid:35367412 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | The Journal of biological chemistry |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35367412 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:9065627 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | J Biol Chem |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9065627 |
| locations[3].id | pmh:oai:diposit.ub.edu:2445/189964 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306401653 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) |
| locations[3].source.host_organization | https://openalex.org/I71999127 |
| locations[3].source.host_organization_name | Universitat de Barcelona |
| locations[3].source.host_organization_lineage | https://openalex.org/I71999127 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | info:eu-repo/semantics/publishedVersion |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
| locations[3].landing_page_url | http://hdl.handle.net/2445/189964 |
| locations[4].id | pmh:oai:arpi.unipi.it:11568/1139110 |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4377196265 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | CINECA IRIS Institutial research information system (University of Pisa) |
| locations[4].source.host_organization | https://openalex.org/I108290504 |
| locations[4].source.host_organization_name | University of Pisa |
| locations[4].source.host_organization_lineage | https://openalex.org/I108290504 |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | info:eu-repo/semantics/article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | |
| locations[4].landing_page_url | http://hdl.handle.net/11568/1139110 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5066429251 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Adrienn Skopál |
| authorships[0].countries | HU |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I132735039 |
| authorships[0].affiliations[0].raw_affiliation_string | Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I132735039 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[0].institutions[0].id | https://openalex.org/I132735039 |
| authorships[0].institutions[0].ror | https://ror.org/02xf66n48 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I132735039 |
| authorships[0].institutions[0].country_code | HU |
| authorships[0].institutions[0].display_name | University of Debrecen |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Adrienn Skopál |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[1].author.id | https://openalex.org/A5028600645 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Tamás Kéki |
| authorships[1].countries | HU |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I132735039 |
| authorships[1].affiliations[0].raw_affiliation_string | Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I132735039 |
| authorships[1].affiliations[1].raw_affiliation_string | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[1].institutions[0].id | https://openalex.org/I132735039 |
| authorships[1].institutions[0].ror | https://ror.org/02xf66n48 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I132735039 |
| authorships[1].institutions[0].country_code | HU |
| authorships[1].institutions[0].display_name | University of Debrecen |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Tamás Kéki |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, Doctoral School of Molecular Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[2].author.id | https://openalex.org/A5086671607 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-9698-8935 |
| authorships[2].author.display_name | Péter Tóth |
| authorships[2].countries | HU |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I132735039 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[2].institutions[0].id | https://openalex.org/I132735039 |
| authorships[2].institutions[0].ror | https://ror.org/02xf66n48 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I132735039 |
| authorships[2].institutions[0].country_code | HU |
| authorships[2].institutions[0].display_name | University of Debrecen |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Péter Á. Tóth |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[3].author.id | https://openalex.org/A5005635984 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-7562-1130 |
| authorships[3].author.display_name | Balázs Csóka |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I78577930 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Anesthesiology, Columbia University, New York, New York, USA |
| authorships[3].institutions[0].id | https://openalex.org/I78577930 |
| authorships[3].institutions[0].ror | https://ror.org/00hj8s172 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I78577930 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Columbia University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Balázs Csóka |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Anesthesiology, Columbia University, New York, New York, USA |
| authorships[4].author.id | https://openalex.org/A5055963250 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-9676-2066 |
| authorships[4].author.display_name | Balázs Koscsó |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I166722992 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA |
| authorships[4].institutions[0].id | https://openalex.org/I166722992 |
| authorships[4].institutions[0].ror | https://ror.org/0464eyp60 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I166722992 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | University of Massachusetts Chan Medical School |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Balázs Koscsó |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts, USA |
| authorships[5].author.id | https://openalex.org/A5101895971 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Zoltán H. Németh |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2802646204 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Surgery, Morristown Medical Center, Morristown, New Jersey, USA |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I78577930 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Anesthesiology, Columbia University, New York, New York, USA |
| authorships[5].institutions[0].id | https://openalex.org/I78577930 |
| authorships[5].institutions[0].ror | https://ror.org/00hj8s172 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I78577930 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Columbia University |
| authorships[5].institutions[1].id | https://openalex.org/I2802646204 |
| authorships[5].institutions[1].ror | https://ror.org/03m6tev69 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I2802646204, https://openalex.org/I67339987 |
| authorships[5].institutions[1].country_code | US |
| authorships[5].institutions[1].display_name | Morristown Medical Center |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Zoltán H. Németh |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Anesthesiology, Columbia University, New York, New York, USA, Department of Surgery, Morristown Medical Center, Morristown, New Jersey, USA |
| authorships[6].author.id | https://openalex.org/A5049744281 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-1241-617X |
| authorships[6].author.display_name | Luca Antonioli |
| authorships[6].countries | IT |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I108290504 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy |
| authorships[6].institutions[0].id | https://openalex.org/I108290504 |
| authorships[6].institutions[0].ror | https://ror.org/03ad39j10 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I108290504 |
| authorships[6].institutions[0].country_code | IT |
| authorships[6].institutions[0].display_name | University of Pisa |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Luca Antonioli |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy |
| authorships[7].author.id | https://openalex.org/A5075372883 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-7578-1337 |
| authorships[7].author.display_name | Andreas Ivessa |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I102322142, https://openalex.org/I4402554120 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA |
| authorships[7].institutions[0].id | https://openalex.org/I4402554120 |
| authorships[7].institutions[0].ror | https://ror.org/014ye1258 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I102322142, https://openalex.org/I4390039302, https://openalex.org/I4402554120 |
| authorships[7].institutions[0].country_code | |
| authorships[7].institutions[0].display_name | Rutgers New Jersey Medical School |
| authorships[7].institutions[1].id | https://openalex.org/I102322142 |
| authorships[7].institutions[1].ror | https://ror.org/05vt9qd57 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I102322142 |
| authorships[7].institutions[1].country_code | US |
| authorships[7].institutions[1].display_name | Rutgers, The State University of New Jersey |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Andreas Ivessa |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA |
| authorships[8].author.id | https://openalex.org/A5032553363 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-0832-3739 |
| authorships[8].author.display_name | Francisco Ciruela |
| authorships[8].countries | ES |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I71999127 |
| authorships[8].affiliations[0].raw_affiliation_string | Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain |
| authorships[8].affiliations[1].institution_ids | https://openalex.org/I2802050225 |
| authorships[8].affiliations[1].raw_affiliation_string | Neuropharmacology and Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, L'Hospitalet de Llobregat, Barcelona, Spain |
| authorships[8].institutions[0].id | https://openalex.org/I2802050225 |
| authorships[8].institutions[0].ror | https://ror.org/00epner96 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I157913058, https://openalex.org/I2802050225, https://openalex.org/I4210153292 |
| authorships[8].institutions[0].country_code | ES |
| authorships[8].institutions[0].display_name | Bellvitge University Hospital |
| authorships[8].institutions[1].id | https://openalex.org/I71999127 |
| authorships[8].institutions[1].ror | https://ror.org/021018s57 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I71999127 |
| authorships[8].institutions[1].country_code | ES |
| authorships[8].institutions[1].display_name | Universitat de Barcelona |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Francisco Ciruela |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Neuropharmacology and Pain Group, Neuroscience Program, Bellvitge Institute for Biomedical Research, L'Hospitalet de Llobregat, Barcelona, Spain, Pharmacology Unit, Department of Pathology and Experimental Therapeutics, School of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain |
| authorships[9].author.id | https://openalex.org/A5091410175 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-7099-6718 |
| authorships[9].author.display_name | László Virág |
| authorships[9].countries | HU |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I132735039 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I132735039 |
| authorships[9].affiliations[1].raw_affiliation_string | MTA-DE Cell Biology and Signaling Research Group, University of Debrecen, Debrecen, Hungary |
| authorships[9].institutions[0].id | https://openalex.org/I132735039 |
| authorships[9].institutions[0].ror | https://ror.org/02xf66n48 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I132735039 |
| authorships[9].institutions[0].country_code | HU |
| authorships[9].institutions[0].display_name | University of Debrecen |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | László Virág |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, MTA-DE Cell Biology and Signaling Research Group, University of Debrecen, Debrecen, Hungary |
| authorships[10].author.id | https://openalex.org/A5048760718 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | György Haskó |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I78577930 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Anesthesiology, Columbia University, New York, New York, USA |
| authorships[10].institutions[0].id | https://openalex.org/I78577930 |
| authorships[10].institutions[0].ror | https://ror.org/00hj8s172 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I78577930 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Columbia University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | György Haskó |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Department of Anesthesiology, Columbia University, New York, New York, USA |
| authorships[11].author.id | https://openalex.org/A5027924406 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-2035-8408 |
| authorships[11].author.display_name | Endre Kókai |
| authorships[11].countries | HU |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I132735039 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary |
| authorships[11].institutions[0].id | https://openalex.org/I132735039 |
| authorships[11].institutions[0].ror | https://ror.org/02xf66n48 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I132735039 |
| authorships[11].institutions[0].country_code | HU |
| authorships[11].institutions[0].display_name | University of Debrecen |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Endre Kókai |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Debrecen, Hungary |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | http://www.jbc.org/article/S0021925822003283/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2022-04-03T00:00:00 |
| display_name | Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11193 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1314 |
| primary_topic.subfield.display_name | Physiology |
| primary_topic.display_name | Adenosine and Purinergic Signaling |
| related_works | https://openalex.org/W2086661051, https://openalex.org/W2023880991, https://openalex.org/W3145111841, https://openalex.org/W2031312553, https://openalex.org/W2272409537, https://openalex.org/W2188270127, https://openalex.org/W2037293282, https://openalex.org/W2010808173, https://openalex.org/W3134199784, https://openalex.org/W2378050394 |
| cited_by_count | 9 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 4 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 2 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1016/j.jbc.2022.101888 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S140251998 |
| best_oa_location.source.issn | 0021-9258, 1067-8816, 1083-351X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 0021-9258 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Journal of Biological Chemistry |
| best_oa_location.source.host_organization | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_name | Elsevier BV |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| best_oa_location.source.host_organization_lineage_names | Elsevier BV |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | http://www.jbc.org/article/S0021925822003283/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Journal of Biological Chemistry |
| best_oa_location.landing_page_url | https://doi.org/10.1016/j.jbc.2022.101888 |
| primary_location.id | doi:10.1016/j.jbc.2022.101888 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S140251998 |
| primary_location.source.issn | 0021-9258, 1067-8816, 1083-351X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 0021-9258 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Journal of Biological Chemistry |
| primary_location.source.host_organization | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_name | Elsevier BV |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320990 |
| primary_location.source.host_organization_lineage_names | Elsevier BV |
| primary_location.license | cc-by |
| primary_location.pdf_url | http://www.jbc.org/article/S0021925822003283/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Biological Chemistry |
| primary_location.landing_page_url | https://doi.org/10.1016/j.jbc.2022.101888 |
| publication_date | 2022-03-31 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2022159206, https://openalex.org/W6676199798, https://openalex.org/W1985935029, https://openalex.org/W1975740938, https://openalex.org/W1980962873, https://openalex.org/W2779964566, https://openalex.org/W2774484667, https://openalex.org/W6714344039, https://openalex.org/W2092347010, https://openalex.org/W3089164168, https://openalex.org/W3111088798, https://openalex.org/W2055085733, https://openalex.org/W1980097469, https://openalex.org/W2163634929, https://openalex.org/W2063225331, https://openalex.org/W1989467245, https://openalex.org/W2010345210, https://openalex.org/W2015191525, https://openalex.org/W2053040310, https://openalex.org/W2189357378, https://openalex.org/W2021899096, https://openalex.org/W1983415181, https://openalex.org/W2153710892, https://openalex.org/W2067993922, https://openalex.org/W2104705300, https://openalex.org/W2055897605, https://openalex.org/W2007612703, https://openalex.org/W2620445856, https://openalex.org/W1995620656, https://openalex.org/W2119408455, https://openalex.org/W1970027494, https://openalex.org/W2100547925, https://openalex.org/W2064362798, https://openalex.org/W2169122721, https://openalex.org/W2322758085, https://openalex.org/W1575186397, https://openalex.org/W1991117131, https://openalex.org/W1937699687, https://openalex.org/W2073271316, https://openalex.org/W2036414840, https://openalex.org/W2035964694, https://openalex.org/W2003483275, https://openalex.org/W1517393168, https://openalex.org/W2038302872, https://openalex.org/W2172047118, https://openalex.org/W2501855129, https://openalex.org/W2055348159, https://openalex.org/W3015080429, https://openalex.org/W3213834885, https://openalex.org/W1987540173, https://openalex.org/W1975632229, https://openalex.org/W1974710770, https://openalex.org/W2119398013, https://openalex.org/W1798102435, https://openalex.org/W2898498783, https://openalex.org/W1972393828, https://openalex.org/W1819773387, https://openalex.org/W2069156204, https://openalex.org/W2007277452, https://openalex.org/W2087265011, https://openalex.org/W2030063490, https://openalex.org/W2409368695, https://openalex.org/W2050946838, https://openalex.org/W2106861254 |
| referenced_works_count | 64 |
| abstract_inverted_index.D | 113 |
| abstract_inverted_index.a | 8, 85, 99, 116, 146, 191 |
| abstract_inverted_index.In | 184 |
| abstract_inverted_index.To | 80 |
| abstract_inverted_index.We | 106, 139 |
| abstract_inverted_index.as | 95, 103 |
| abstract_inverted_index.be | 204 |
| abstract_inverted_index.in | 5, 11, 28, 62, 71, 124, 127, 166, 182, 210 |
| abstract_inverted_index.is | 54, 145, 190 |
| abstract_inverted_index.it | 45, 53 |
| abstract_inverted_index.of | 14, 38, 93, 148, 154, 164, 180 |
| abstract_inverted_index.to | 22, 48, 67 |
| abstract_inverted_index.we | 65, 83, 169, 186 |
| abstract_inverted_index.For | 33 |
| abstract_inverted_index.RAW | 131 |
| abstract_inverted_index.The | 119 |
| abstract_inverted_index.and | 26, 41, 78, 98, 126, 133, 150, 160, 177, 195, 199 |
| abstract_inverted_index.are | 30, 46 |
| abstract_inverted_index.for | 206 |
| abstract_inverted_index.key | 9 |
| abstract_inverted_index.may | 74, 203 |
| abstract_inverted_index.the | 12, 17, 23, 35, 39, 90, 96, 104, 109, 143, 152, 158, 175 |
| abstract_inverted_index.was | 115, 122 |
| abstract_inverted_index.CtsD | 149, 155, 181, 189 |
| abstract_inverted_index.also | 140 |
| abstract_inverted_index.cell | 24, 161 |
| abstract_inverted_index.end, | 82 |
| abstract_inverted_index.have | 61 |
| abstract_inverted_index.hit. | 118 |
| abstract_inverted_index.role | 10, 57 |
| abstract_inverted_index.tail | 92 |
| abstract_inverted_index.that | 73, 108, 142, 151, 171, 188, 202 |
| abstract_inverted_index.this | 81 |
| abstract_inverted_index.thus | 196 |
| abstract_inverted_index.what | 56 |
| abstract_inverted_index.with | 44 |
| abstract_inverted_index.264.7 | 132 |
| abstract_inverted_index.Here, | 64 |
| abstract_inverted_index.aimed | 66 |
| abstract_inverted_index.found | 107 |
| abstract_inverted_index.known | 47 |
| abstract_inverted_index.mouse | 134 |
| abstract_inverted_index.novel | 192 |
| abstract_inverted_index.plays | 7 |
| abstract_inverted_index.using | 89 |
| abstract_inverted_index.vitro | 125 |
| abstract_inverted_index.yeast | 86 |
| abstract_inverted_index."bait" | 97 |
| abstract_inverted_index.(CtsD) | 114 |
| abstract_inverted_index.cells. | 138 |
| abstract_inverted_index.domain | 37 |
| abstract_inverted_index.effect | 75 |
| abstract_inverted_index.robust | 117 |
| abstract_inverted_index.screen | 88 |
| abstract_inverted_index."prey." | 105 |
| abstract_inverted_index.(IPMΦ) | 137 |
| abstract_inverted_index.crucial | 205 |
| abstract_inverted_index.density | 159 |
| abstract_inverted_index.library | 102 |
| abstract_inverted_index.models, | 129 |
| abstract_inverted_index.partner | 194 |
| abstract_inverted_index.prompts | 174 |
| abstract_inverted_index.surface | 25, 162 |
| abstract_inverted_index.unclear | 55 |
| abstract_inverted_index.However, | 16 |
| abstract_inverted_index.activity | 156, 179 |
| abstract_inverted_index.although | 52 |
| abstract_inverted_index.blockade | 153 |
| abstract_inverted_index.cellular | 128 |
| abstract_inverted_index.conclude | 187 |
| abstract_inverted_index.describe | 197 |
| abstract_inverted_index.example, | 34 |
| abstract_inverted_index.identify | 68 |
| abstract_inverted_index.partners | 60, 70 |
| abstract_inverted_index.protease | 111 |
| abstract_inverted_index.proteins | 42 |
| abstract_inverted_index.receptor | 2, 50, 76 |
| abstract_inverted_index.regulate | 49 |
| abstract_inverted_index.summary, | 185 |
| abstract_inverted_index.Adenosine | 0 |
| abstract_inverted_index.activity. | 79 |
| abstract_inverted_index.cathepsin | 112 |
| abstract_inverted_index.enzymatic | 178 |
| abstract_inverted_index.including | 130 |
| abstract_inverted_index.increases | 157 |
| abstract_inverted_index.interplay | 201 |
| abstract_inverted_index.lysosomal | 110 |
| abstract_inverted_index.molecular | 198 |
| abstract_inverted_index.performed | 84 |
| abstract_inverted_index.potential | 58 |
| abstract_inverted_index.processes | 18 |
| abstract_inverted_index.signaling | 4 |
| abstract_inverted_index.substrate | 147 |
| abstract_inverted_index.targeting | 21, 163 |
| abstract_inverted_index.validated | 123 |
| abstract_inverted_index.C-terminal | 36, 91 |
| abstract_inverted_index.activation | 173 |
| abstract_inverted_index.expression | 101 |
| abstract_inverted_index.functional | 200 |
| abstract_inverted_index.macrophage | 100, 136, 208 |
| abstract_inverted_index.maturation | 176 |
| abstract_inverted_index.peritoneal | 135 |
| abstract_inverted_index.processes. | 212 |
| abstract_inverted_index.recycling, | 51 |
| abstract_inverted_index.regulating | 19 |
| abstract_inverted_index.regulation | 13, 209 |
| abstract_inverted_index.two-hybrid | 87 |
| abstract_inverted_index.Conversely, | 168 |
| abstract_inverted_index.degradation | 27 |
| abstract_inverted_index.demonstrate | 170 |
| abstract_inverted_index.interacting | 43 |
| abstract_inverted_index.interaction | 121 |
| abstract_inverted_index.macrophages | 6, 29, 72 |
| abstract_inverted_index.trafficking | 77 |
| abstract_inverted_index.understood. | 32 |
| abstract_inverted_index.demonstrated | 141 |
| abstract_inverted_index.incompletely | 31 |
| abstract_inverted_index.inflammatory | 211 |
| abstract_inverted_index.macrophages. | 63, 167, 183 |
| abstract_inverted_index.inflammation. | 15 |
| abstract_inverted_index.A<sub>2A</sub> | 1 |
| abstract_inverted_index.A<sub>2A</sub>R | 20, 40, 94, 144, 165, 172 |
| abstract_inverted_index.adenosine-mediated | 207 |
| abstract_inverted_index.A<sub>2A</sub>R-CtsD | 120 |
| abstract_inverted_index.(A<sub>2A</sub>R)-dependent | 3 |
| abstract_inverted_index.A<sub>2A</sub>R-interacting | 59, 69, 193 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5027924406, https://openalex.org/A5048760718 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I132735039, https://openalex.org/I78577930 |
| citation_normalized_percentile.value | 0.79085457 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |