CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion Article Swipe
Pengcheng Zhou
,
Sonia Erfani
,
Zeyi Liu
,
Changhe Jia
,
Yecang Chen
,
Bingwei Xu
,
Xinyu Deng
,
Jose Alfaro
,
Li Chen
,
Dana Napier
,
Michael L. Lu
,
Jian‐An Huang
,
Chunming Liu
,
Olivier Thibault
,
Rosalind A. Segal
,
Binhua P. Zhou
,
Natasha Kyprianou
,
Craig Horbinski
,
Xiuwei H. Yang
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.4896
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.18632/oncotarget.4896
Glioblastoma, one of the most aggressive forms of brain cancer, is featured by high tumor cell motility and invasiveness, which not only fuel tumor infiltration, but also enable escape from surgical or other clinical interventions. Thus, better understanding of how these malignant traits are controlled will be key to the discovery of novel biomarkers and therapies against this deadly disease. Tetraspanin CD151 and its associated α3β1 integrin have been implicated in facilitating tumor progression across multiple cancer types. How these adhesion molecules are involved in the progression of glioblastoma, however, remains largely unclear. Here, we examined an in-house tissue microarray-based cohort of 96 patient biopsies and TCGA dataset to evaluate the clinical significance of CD151 and α3β1 integrin. Functional and signaling analyses were also conducted to understand how these molecules promote the aggressiveness of glioblastoma at molecular and cellular levels. Results from our analyses showed that CD151 and α3 integrin were significantly elevated in glioblastomas at both protein and mRNA levels, and exhibited strong inverse correlation with patient survival (p < 0.006). These adhesion molecules also formed tight protein complexes and synergized with EGF/EGFR to accelerate tumor cell motility and invasion. Furthermore, disruption of such complexes enhanced the survival of tumor-bearing mice in a xenograft model, and impaired activation of FAK and small GTPases. Also, knockdown- or pharmacological agent-based attenuation of EGFR, FAK or Graf (ARHGAP26)/small GTPase-mediated pathways markedly mitigated the aggressiveness of glioblastoma cells. Collectively, our findings provide clinical, molecular and cellular evidence of CD151-α3β1 integrin complexes as promising prognostic biomarkers and therapeutic targets for glioblastoma.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.18632/oncotarget.4896
- https://www.oncotarget.com/article/4896/pdf/
- OA Status
- diamond
- Cited By
- 80
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W1841468843
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W1841468843Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.18632/oncotarget.4896Digital Object Identifier
- Title
-
CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-08-13Full publication date if available
- Authors
-
Pengcheng Zhou, Sonia Erfani, Zeyi Liu, Changhe Jia, Yecang Chen, Bingwei Xu, Xinyu Deng, Jose Alfaro, Li Chen, Dana Napier, Michael L. Lu, Jian‐An Huang, Chunming Liu, Olivier Thibault, Rosalind A. Segal, Binhua P. Zhou, Natasha Kyprianou, Craig Horbinski, Xiuwei H. YangList of authors in order
- Landing page
-
https://doi.org/10.18632/oncotarget.4896Publisher landing page
- PDF URL
-
https://www.oncotarget.com/article/4896/pdf/Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.oncotarget.com/article/4896/pdf/Direct OA link when available
- Concepts
-
Cancer research, Integrin, Tetraspanin, Tumor progression, Motility, Cell adhesion molecule, Biology, Focal adhesion, Gene knockdown, Cancer, Medicine, Cell, Signal transduction, Immunology, Cell biology, Cell culture, Internal medicine, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
80Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 4, 2023: 4, 2022: 10, 2021: 32Per-year citation counts (last 5 years)
- References (count)
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57Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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