CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas Article Swipe
Jaime Miguel Gomes Pita
,
Eric Raspé
,
Katia Coulonval
,
Myriam Decaussin‐Petrucci
,
Maxime Tarabichi
,
Geert Dom
,
Frédérick Libert
,
Ligia Craciun
,
Guy Andry
,
Laurence Wicquart
,
Emmanuelle Leteurtre
,
C. Trésallet
,
Laura A. Marlow
,
John A. Copland
,
Cosimo Durante
,
Carine Maenhaut
,
Branca Cavaco
,
Jacques E. Dumont
,
Giuseppe Costante
,
Pierre P. Roger
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1247542
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2023.1247542
Background CDK4/6 inhibitors (CDK4/6i) have been established as standard treatment against advanced Estrogen Receptor-positive breast cancers. These drugs are being tested against several cancers, including in combinations with other therapies. We identified the T172-phosphorylation of CDK4 as the step determining its activity, retinoblastoma protein (RB) inactivation, cell cycle commitment and sensitivity to CDK4/6i. Poorly differentiated (PDTC) and anaplastic (ATC) thyroid carcinomas, the latter considered one of the most lethal human malignancies, represent major clinical challenges. Several molecular evidence suggest that CDK4/6i could be considered for treating these advanced thyroid cancers. Methods We analyzed by two-dimensional gel electrophoresis the CDK4 modification profile and the presence of T172-phosphorylated CDK4 in a collection of 98 fresh-frozen tissues and in 21 cell lines. A sub-cohort of samples was characterized by RNA sequencing and immunohistochemistry. Sensitivity to CDK4/6i (palbociclib and abemaciclib) was assessed by BrdU incorporation/viability assays. Treatment of cell lines with CDK4/6i and combination with BRAF/MEK inhibitors (dabrafenib/trametinib) was comprehensively evaluated by western blot, characterization of immunoprecipitated CDK4 and CDK2 complexes and clonogenic assays. Results CDK4 phosphorylation was detected in all well-differentiated thyroid carcinomas (n=29), 19/20 PDTC, 16/23 ATC and 18/21 thyroid cancer cell lines, including 11 ATC-derived ones. Tumors and cell lines without phosphorylated CDK4 presented very high p16 CDKN2A levels, which were associated with proliferative activity. Absence of CDK4 phosphorylation in cell lines was associated with CDK4/6i insensitivity. RB1 defects (the primary cause of intrinsic CDK4/6i resistance) were not found in 5/7 tumors without detectable phosphorylated CDK4. A previously developed 11-gene expression signature identified the likely unresponsive tumors, lacking CDK4 phosphorylation. In cell lines, palbociclib synergized with dabrafenib/trametinib by completely and permanently arresting proliferation. These combinations prevented resistance mechanisms induced by palbociclib, most notably Cyclin E1-CDK2 activation and a paradoxical stabilization of phosphorylated CDK4 complexes. Conclusion Our study supports further clinical evaluation of CDK4/6i and their combination with anti-BRAF/MEK therapies as a novel effective treatment against advanced thyroid tumors. Moreover, the complementary use of our 11 genes predictor with p16/KI67 evaluation could represent a prompt tool for recognizing the intrinsically CDK4/6i insensitive patients, who are potentially better candidates to immediate chemotherapy.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2023.1247542
- OA Status
- gold
- Cited By
- 6
- References
- 125
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388194957
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4388194957Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2023.1247542Digital Object Identifier
- Title
-
CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomasWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-10-26Full publication date if available
- Authors
-
Jaime Miguel Gomes Pita, Eric Raspé, Katia Coulonval, Myriam Decaussin‐Petrucci, Maxime Tarabichi, Geert Dom, Frédérick Libert, Ligia Craciun, Guy Andry, Laurence Wicquart, Emmanuelle Leteurtre, C. Trésallet, Laura A. Marlow, John A. Copland, Cosimo Durante, Carine Maenhaut, Branca Cavaco, Jacques E. Dumont, Giuseppe Costante, Pierre P. RogerList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2023.1247542Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fendo.2023.1247542Direct OA link when available
- Concepts
-
Cancer research, Thyroid carcinoma, Phosphorylation, Thyroid, Oncology, Medicine, Internal medicine, Biology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 3Per-year citation counts (last 5 years)
- References (count)
-
125Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4388194957 |
|---|---|
| doi | https://doi.org/10.3389/fendo.2023.1247542 |
| ids.doi | https://doi.org/10.3389/fendo.2023.1247542 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37964967 |
| ids.openalex | https://openalex.org/W4388194957 |
| fwci | 2.02424991 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D010766 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Phosphorylation |
| mesh[2].qualifier_ui | Q000235 |
| mesh[2].descriptor_ui | D048493 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | genetics |
| mesh[2].descriptor_name | Proto-Oncogene Proteins B-raf |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D045744 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Cell Line, Tumor |
| mesh[4].qualifier_ui | Q000188 |
| mesh[4].descriptor_ui | D013964 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | drug therapy |
| mesh[4].descriptor_name | Thyroid Neoplasms |
| mesh[5].qualifier_ui | Q000494 |
| mesh[5].descriptor_ui | D047428 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | pharmacology |
| mesh[5].descriptor_name | Protein Kinase Inhibitors |
| mesh[6].qualifier_ui | Q000627 |
| mesh[6].descriptor_ui | D047428 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | therapeutic use |
| mesh[6].descriptor_name | Protein Kinase Inhibitors |
| mesh[7].qualifier_ui | Q000188 |
| mesh[7].descriptor_ui | D065646 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | drug therapy |
| mesh[7].descriptor_name | Thyroid Carcinoma, Anaplastic |
| mesh[8].qualifier_ui | Q000378 |
| mesh[8].descriptor_ui | D020929 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | metabolism |
| mesh[8].descriptor_name | Mitogen-Activated Protein Kinase Kinases |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D051358 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Cyclin-Dependent Kinase 4 |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D007093 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Imidazoles |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D010091 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Oximes |
| mesh[12].qualifier_ui | Q000031 |
| mesh[12].descriptor_ui | D011392 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | analogs & derivatives |
| mesh[12].descriptor_name | Proline |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D013859 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Thiocarbamates |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D006801 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Humans |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D010766 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Phosphorylation |
| mesh[16].qualifier_ui | Q000235 |
| mesh[16].descriptor_ui | D048493 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | genetics |
| mesh[16].descriptor_name | Proto-Oncogene Proteins B-raf |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D045744 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Cell Line, Tumor |
| mesh[18].qualifier_ui | Q000188 |
| mesh[18].descriptor_ui | D013964 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | drug therapy |
| mesh[18].descriptor_name | Thyroid Neoplasms |
| mesh[19].qualifier_ui | Q000494 |
| mesh[19].descriptor_ui | D047428 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | pharmacology |
| mesh[19].descriptor_name | Protein Kinase Inhibitors |
| mesh[20].qualifier_ui | Q000627 |
| mesh[20].descriptor_ui | D047428 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | therapeutic use |
| mesh[20].descriptor_name | Protein Kinase Inhibitors |
| mesh[21].qualifier_ui | Q000188 |
| mesh[21].descriptor_ui | D065646 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | drug therapy |
| mesh[21].descriptor_name | Thyroid Carcinoma, Anaplastic |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D020929 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Mitogen-Activated Protein Kinase Kinases |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D051358 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Cyclin-Dependent Kinase 4 |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D007093 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Imidazoles |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D010091 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Oximes |
| mesh[26].qualifier_ui | Q000031 |
| mesh[26].descriptor_ui | D011392 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | analogs & derivatives |
| mesh[26].descriptor_name | Proline |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D013859 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Thiocarbamates |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D006801 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Humans |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D010766 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Phosphorylation |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D048493 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | Proto-Oncogene Proteins B-raf |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D045744 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Cell Line, Tumor |
| mesh[32].qualifier_ui | Q000188 |
| mesh[32].descriptor_ui | D013964 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | drug therapy |
| mesh[32].descriptor_name | Thyroid Neoplasms |
| mesh[33].qualifier_ui | Q000494 |
| mesh[33].descriptor_ui | D047428 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | pharmacology |
| mesh[33].descriptor_name | Protein Kinase Inhibitors |
| mesh[34].qualifier_ui | Q000627 |
| mesh[34].descriptor_ui | D047428 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | therapeutic use |
| mesh[34].descriptor_name | Protein Kinase Inhibitors |
| mesh[35].qualifier_ui | Q000188 |
| mesh[35].descriptor_ui | D065646 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | drug therapy |
| mesh[35].descriptor_name | Thyroid Carcinoma, Anaplastic |
| mesh[36].qualifier_ui | Q000378 |
| mesh[36].descriptor_ui | D020929 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | metabolism |
| mesh[36].descriptor_name | Mitogen-Activated Protein Kinase Kinases |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D051358 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Cyclin-Dependent Kinase 4 |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D007093 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Imidazoles |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D010091 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Oximes |
| mesh[40].qualifier_ui | Q000031 |
| mesh[40].descriptor_ui | D011392 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | analogs & derivatives |
| mesh[40].descriptor_name | Proline |
| mesh[41].qualifier_ui | |
| mesh[41].descriptor_ui | D013859 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | |
| mesh[41].descriptor_name | Thiocarbamates |
| type | article |
| title | CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas |
| biblio.issue | |
| biblio.volume | 14 |
| biblio.last_page | 1247542 |
| biblio.first_page | 1247542 |
| grants[0].funder | https://openalex.org/F4320321390 |
| grants[0].award_id | J.0002.16, J.0141.19, J.0169.22 |
| grants[0].funder_display_name | Fonds De La Recherche Scientifique - FNRS |
| grants[1].funder | https://openalex.org/F4320323739 |
| grants[1].award_id | Fund Doctor J.P. Naets |
| grants[1].funder_display_name | Koning Boudewijnstichting |
| grants[2].funder | https://openalex.org/F4320325019 |
| grants[2].award_id | |
| grants[2].funder_display_name | Amis de l'Institut Bordet |
| grants[3].funder | https://openalex.org/F4320328144 |
| grants[3].award_id | 2014-130, 2018-138 |
| grants[3].funder_display_name | Fondation contre le Cancer |
| grants[4].funder | https://openalex.org/F4320334779 |
| grants[4].award_id | UIDB/04462/2020, UIDP/04462/2020, LA/P/0087/2020 |
| grants[4].funder_display_name | Fundação para a Ciência e a Tecnologia |
| topics[0].id | https://openalex.org/T12829 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9987000226974487 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Advanced Breast Cancer Therapies |
| topics[1].id | https://openalex.org/T10583 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9970999956130981 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2730 |
| topics[1].subfield.display_name | Oncology |
| topics[1].display_name | Cancer-related Molecular Pathways |
| topics[2].id | https://openalex.org/T10329 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9829000234603882 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2712 |
| topics[2].subfield.display_name | Endocrinology, Diabetes and Metabolism |
| topics[2].display_name | Thyroid Cancer Diagnosis and Treatment |
| funders[0].id | https://openalex.org/F4320321390 |
| funders[0].ror | https://ror.org/03q83t159 |
| funders[0].display_name | Fonds De La Recherche Scientifique - FNRS |
| funders[1].id | https://openalex.org/F4320323739 |
| funders[1].ror | https://ror.org/02am44w88 |
| funders[1].display_name | Koning Boudewijnstichting |
| funders[2].id | https://openalex.org/F4320325019 |
| funders[2].ror | https://ror.org/0073n0s52 |
| funders[2].display_name | Amis de l'Institut Bordet |
| funders[3].id | https://openalex.org/F4320328144 |
| funders[3].ror | |
| funders[3].display_name | Fondation contre le Cancer |
| funders[4].id | https://openalex.org/F4320334779 |
| funders[4].ror | https://ror.org/00snfqn58 |
| funders[4].display_name | Fundação para a Ciência e a Tecnologia |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C502942594 |
| concepts[0].level | 1 |
| concepts[0].score | 0.6608070731163025 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[0].display_name | Cancer research |
| concepts[1].id | https://openalex.org/C2993294228 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6325206756591797 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q13632630 |
| concepts[1].display_name | Thyroid carcinoma |
| concepts[2].id | https://openalex.org/C11960822 |
| concepts[2].level | 2 |
| concepts[2].score | 0.5367200970649719 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q242736 |
| concepts[2].display_name | Phosphorylation |
| concepts[3].id | https://openalex.org/C526584372 |
| concepts[3].level | 2 |
| concepts[3].score | 0.4800366163253784 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q16399 |
| concepts[3].display_name | Thyroid |
| concepts[4].id | https://openalex.org/C143998085 |
| concepts[4].level | 1 |
| concepts[4].score | 0.4553147256374359 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q162555 |
| concepts[4].display_name | Oncology |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.42032328248023987 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C126322002 |
| concepts[6].level | 1 |
| concepts[6].score | 0.37528181076049805 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[6].display_name | Internal medicine |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.3554595708847046 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C54355233 |
| concepts[8].level | 1 |
| concepts[8].score | 0.14764881134033203 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[8].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/cancer-research |
| keywords[0].score | 0.6608070731163025 |
| keywords[0].display_name | Cancer research |
| keywords[1].id | https://openalex.org/keywords/thyroid-carcinoma |
| keywords[1].score | 0.6325206756591797 |
| keywords[1].display_name | Thyroid carcinoma |
| keywords[2].id | https://openalex.org/keywords/phosphorylation |
| keywords[2].score | 0.5367200970649719 |
| keywords[2].display_name | Phosphorylation |
| keywords[3].id | https://openalex.org/keywords/thyroid |
| keywords[3].score | 0.4800366163253784 |
| keywords[3].display_name | Thyroid |
| keywords[4].id | https://openalex.org/keywords/oncology |
| keywords[4].score | 0.4553147256374359 |
| keywords[4].display_name | Oncology |
| keywords[5].id | https://openalex.org/keywords/medicine |
| keywords[5].score | 0.42032328248023987 |
| keywords[5].display_name | Medicine |
| keywords[6].id | https://openalex.org/keywords/internal-medicine |
| keywords[6].score | 0.37528181076049805 |
| keywords[6].display_name | Internal medicine |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.3554595708847046 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/genetics |
| keywords[8].score | 0.14764881134033203 |
| keywords[8].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.3389/fendo.2023.1247542 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2597401208 |
| locations[0].source.issn | 1664-2392 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-2392 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Endocrinology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Endocrinology |
| locations[0].landing_page_url | https://doi.org/10.3389/fendo.2023.1247542 |
| locations[1].id | pmid:37964967 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in endocrinology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37964967 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10641312 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10641312/pdf/fendo-14-1247542.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Front Endocrinol (Lausanne) |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10641312 |
| locations[3].id | pmh:oai:HAL:hal-04535283v1 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306402512 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[3].source.host_organization | https://openalex.org/I1294671590 |
| locations[3].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[3].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | info:eu-repo/semantics/article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | ISSN: 1664-2392 |
| locations[3].landing_page_url | https://hal.science/hal-04535283 |
| locations[4].id | pmh:oai:doaj.org/article:6abad13998f7473bad18f0d24f04952e |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].source.host_organization_lineage | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Frontiers in Endocrinology, Vol 14 (2023) |
| locations[4].landing_page_url | https://doaj.org/article/6abad13998f7473bad18f0d24f04952e |
| locations[5].id | pmh:oai:dipot.ulb.ac.be:2013/365060 |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306401063 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) |
| locations[5].source.host_organization | https://openalex.org/I132053463 |
| locations[5].source.host_organization_name | Université Libre de Bruxelles |
| locations[5].source.host_organization_lineage | https://openalex.org/I132053463 |
| locations[5].license | other-oa |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | info:ulb-repo/semantics/openurl/article |
| locations[5].license_id | https://openalex.org/licenses/other-oa |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Frontiers in endocrinology, 14 |
| locations[5].landing_page_url | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/365060 |
| locations[6].id | pmh:oai:HAL:hal-04525462v1 |
| locations[6].is_oa | False |
| locations[6].source.id | https://openalex.org/S4306402512 |
| locations[6].source.issn | |
| locations[6].source.type | repository |
| locations[6].source.is_oa | False |
| locations[6].source.issn_l | |
| locations[6].source.is_core | False |
| locations[6].source.is_in_doaj | False |
| locations[6].source.display_name | HAL (Le Centre pour la Communication Scientifique Directe) |
| locations[6].source.host_organization | https://openalex.org/I1294671590 |
| locations[6].source.host_organization_name | Centre National de la Recherche Scientifique |
| locations[6].source.host_organization_lineage | https://openalex.org/I1294671590 |
| locations[6].license | |
| locations[6].pdf_url | |
| locations[6].version | submittedVersion |
| locations[6].raw_type | Journal articles |
| locations[6].license_id | |
| locations[6].is_accepted | False |
| locations[6].is_published | False |
| locations[6].raw_source_name | Frontiers in Endocrinology, 2023, 14, ⟨10.3389/fendo.2023.1247542⟩ |
| locations[6].landing_page_url | https://hal.science/hal-04525462 |
| locations[7].id | pmh:oai:iris.uniroma1.it:11573/1699715 |
| locations[7].is_oa | False |
| locations[7].source.id | https://openalex.org/S4377196107 |
| locations[7].source.issn | |
| locations[7].source.type | repository |
| locations[7].source.is_oa | False |
| locations[7].source.issn_l | |
| locations[7].source.is_core | False |
| locations[7].source.is_in_doaj | False |
| locations[7].source.display_name | IRIS Research product catalog (Sapienza University of Rome) |
| locations[7].source.host_organization | |
| locations[7].source.host_organization_name | |
| locations[7].source.host_organization_lineage | |
| locations[7].license | |
| locations[7].pdf_url | |
| locations[7].version | submittedVersion |
| locations[7].raw_type | info:eu-repo/semantics/article |
| locations[7].license_id | |
| locations[7].is_accepted | False |
| locations[7].is_published | False |
| locations[7].raw_source_name | |
| locations[7].landing_page_url | https://hdl.handle.net/11573/1699715 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5029595400 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-7186-1049 |
| authorships[0].author.display_name | Jaime Miguel Gomes Pita |
| authorships[0].countries | BE |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I132053463 |
| authorships[0].affiliations[0].raw_affiliation_string | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[0].institutions[0].id | https://openalex.org/I132053463 |
| authorships[0].institutions[0].ror | https://ror.org/01r9htc13 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I132053463 |
| authorships[0].institutions[0].country_code | BE |
| authorships[0].institutions[0].display_name | Université Libre de Bruxelles |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jaime M. Pita |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[1].author.id | https://openalex.org/A5009905753 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5899-1842 |
| authorships[1].author.display_name | Eric Raspé |
| authorships[1].countries | BE |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I132053463 |
| authorships[1].affiliations[0].raw_affiliation_string | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[1].institutions[0].id | https://openalex.org/I132053463 |
| authorships[1].institutions[0].ror | https://ror.org/01r9htc13 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I132053463 |
| authorships[1].institutions[0].country_code | BE |
| authorships[1].institutions[0].display_name | Université Libre de Bruxelles |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Eric Raspé |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[2].author.id | https://openalex.org/A5074666118 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-3799-569X |
| authorships[2].author.display_name | Katia Coulonval |
| authorships[2].countries | BE |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I132053463 |
| authorships[2].affiliations[0].raw_affiliation_string | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[2].institutions[0].id | https://openalex.org/I132053463 |
| authorships[2].institutions[0].ror | https://ror.org/01r9htc13 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I132053463 |
| authorships[2].institutions[0].country_code | BE |
| authorships[2].institutions[0].display_name | Université Libre de Bruxelles |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Katia Coulonval |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[3].author.id | https://openalex.org/A5007578355 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-6065-0756 |
| authorships[3].author.display_name | Myriam Decaussin‐Petrucci |
| authorships[3].countries | FR |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I100532134 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pathology, Lyon Sud Hospital, Claude Bernard Lyon 1 University, Lyon, France |
| authorships[3].institutions[0].id | https://openalex.org/I100532134 |
| authorships[3].institutions[0].ror | https://ror.org/029brtt94 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I100532134, https://openalex.org/I203339264 |
| authorships[3].institutions[0].country_code | FR |
| authorships[3].institutions[0].display_name | Université Claude Bernard Lyon 1 |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Myriam Decaussin-Petrucci |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pathology, Lyon Sud Hospital, Claude Bernard Lyon 1 University, Lyon, France |
| authorships[4].author.id | https://openalex.org/A5045412483 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1635-2348 |
| authorships[4].author.display_name | Maxime Tarabichi |
| authorships[4].countries | BE |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I132053463 |
| authorships[4].affiliations[0].raw_affiliation_string | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[4].institutions[0].id | https://openalex.org/I132053463 |
| authorships[4].institutions[0].ror | https://ror.org/01r9htc13 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I132053463 |
| authorships[4].institutions[0].country_code | BE |
| authorships[4].institutions[0].display_name | Université Libre de Bruxelles |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Maxime Tarabichi |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[5].author.id | https://openalex.org/A5076290422 |
| authorships[5].author.orcid | https://orcid.org/0000-0001-6492-0429 |
| authorships[5].author.display_name | Geert Dom |
| authorships[5].countries | BE |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I132053463 |
| authorships[5].affiliations[0].raw_affiliation_string | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[5].institutions[0].id | https://openalex.org/I132053463 |
| authorships[5].institutions[0].ror | https://ror.org/01r9htc13 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I132053463 |
| authorships[5].institutions[0].country_code | BE |
| authorships[5].institutions[0].display_name | Université Libre de Bruxelles |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Geneviève Dom |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[6].author.id | https://openalex.org/A5110966482 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Frédérick Libert |
| authorships[6].countries | BE |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I132053463 |
| authorships[6].affiliations[0].raw_affiliation_string | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I132053463 |
| authorships[6].affiliations[1].raw_affiliation_string | BRIGHTCore, Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[6].institutions[0].id | https://openalex.org/I132053463 |
| authorships[6].institutions[0].ror | https://ror.org/01r9htc13 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I132053463 |
| authorships[6].institutions[0].country_code | BE |
| authorships[6].institutions[0].display_name | Université Libre de Bruxelles |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Frederick Libert |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | BRIGHTCore, Université Libre de Bruxelles (ULB), Brussels, Belgium, Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[7].author.id | https://openalex.org/A5076384990 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-6540-8232 |
| authorships[7].author.display_name | Ligia Craciun |
| authorships[7].countries | BE |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I132053463, https://openalex.org/I2801838318 |
| authorships[7].affiliations[0].raw_affiliation_string | Tumor Bank of the Institut Jules Bordet Comprehensive Cancer Center – Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[7].institutions[0].id | https://openalex.org/I2801838318 |
| authorships[7].institutions[0].ror | https://ror.org/05e8s8534 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I2801838318 |
| authorships[7].institutions[0].country_code | BE |
| authorships[7].institutions[0].display_name | Institut Jules Bordet |
| authorships[7].institutions[1].id | https://openalex.org/I132053463 |
| authorships[7].institutions[1].ror | https://ror.org/01r9htc13 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I132053463 |
| authorships[7].institutions[1].country_code | BE |
| authorships[7].institutions[1].display_name | Université Libre de Bruxelles |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Ligia Craciun |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Tumor Bank of the Institut Jules Bordet Comprehensive Cancer Center – Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[8].author.id | https://openalex.org/A5045989494 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-7410-6519 |
| authorships[8].author.display_name | Guy Andry |
| authorships[8].countries | BE |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I132053463, https://openalex.org/I2801838318 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Head & Neck and Thoracic Surgery, Institut Jules Bordet Comprehensive Cancer Center – Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[8].institutions[0].id | https://openalex.org/I2801838318 |
| authorships[8].institutions[0].ror | https://ror.org/05e8s8534 |
| authorships[8].institutions[0].type | healthcare |
| authorships[8].institutions[0].lineage | https://openalex.org/I2801838318 |
| authorships[8].institutions[0].country_code | BE |
| authorships[8].institutions[0].display_name | Institut Jules Bordet |
| authorships[8].institutions[1].id | https://openalex.org/I132053463 |
| authorships[8].institutions[1].ror | https://ror.org/01r9htc13 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I132053463 |
| authorships[8].institutions[1].country_code | BE |
| authorships[8].institutions[1].display_name | Université Libre de Bruxelles |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Guy Andry |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Head & Neck and Thoracic Surgery, Institut Jules Bordet Comprehensive Cancer Center – Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[9].author.id | https://openalex.org/A5069783839 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Laurence Wicquart |
| authorships[9].countries | FR |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210110701 |
| authorships[9].affiliations[0].raw_affiliation_string | Tumorothèque du Groupement de Coopération Sanitaire-Centre Régional de Référence en Cancérologie (C2RC) de Lille, Lille, France |
| authorships[9].institutions[0].id | https://openalex.org/I4210110701 |
| authorships[9].institutions[0].ror | https://ror.org/01xw83c56 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210110701 |
| authorships[9].institutions[0].country_code | FR |
| authorships[9].institutions[0].display_name | Registre général des cancers de Lille et de sa région |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Laurence Wicquart |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Tumorothèque du Groupement de Coopération Sanitaire-Centre Régional de Référence en Cancérologie (C2RC) de Lille, Lille, France |
| authorships[10].author.id | https://openalex.org/A5045830986 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-2118-0704 |
| authorships[10].author.display_name | Emmanuelle Leteurtre |
| authorships[10].countries | FR |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I2279609970, https://openalex.org/I4387152542 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Pathology, Univ. Lille, Centre National de la Recherche Scientifique (CNRS), Inserm, Centre Hospitalo-Universitaire (CHU) Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, Lille, France |
| authorships[10].institutions[0].id | https://openalex.org/I4387152542 |
| authorships[10].institutions[0].ror | https://ror.org/05x9zmx47 |
| authorships[10].institutions[0].type | facility |
| authorships[10].institutions[0].lineage | https://openalex.org/I1294671590, https://openalex.org/I154526488, https://openalex.org/I2279609970, https://openalex.org/I2800921988, https://openalex.org/I3018718406, https://openalex.org/I4210131356, https://openalex.org/I4210141925, https://openalex.org/I4387152542 |
| authorships[10].institutions[0].country_code | |
| authorships[10].institutions[0].display_name | CANTHER - Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers |
| authorships[10].institutions[1].id | https://openalex.org/I1294671590 |
| authorships[10].institutions[1].ror | https://ror.org/02feahw73 |
| authorships[10].institutions[1].type | government |
| authorships[10].institutions[1].lineage | https://openalex.org/I1294671590 |
| authorships[10].institutions[1].country_code | FR |
| authorships[10].institutions[1].display_name | Centre National de la Recherche Scientifique |
| authorships[10].institutions[2].id | https://openalex.org/I154526488 |
| authorships[10].institutions[2].ror | https://ror.org/02vjkv261 |
| authorships[10].institutions[2].type | government |
| authorships[10].institutions[2].lineage | https://openalex.org/I154526488 |
| authorships[10].institutions[2].country_code | FR |
| authorships[10].institutions[2].display_name | Inserm |
| authorships[10].institutions[3].id | https://openalex.org/I2279609970 |
| authorships[10].institutions[3].ror | https://ror.org/02kzqn938 |
| authorships[10].institutions[3].type | education |
| authorships[10].institutions[3].lineage | https://openalex.org/I2279609970 |
| authorships[10].institutions[3].country_code | FR |
| authorships[10].institutions[3].display_name | Université de Lille |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Emmanuelle Leteurtre |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Pathology, Univ. Lille, Centre National de la Recherche Scientifique (CNRS), Inserm, Centre Hospitalo-Universitaire (CHU) Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity, Plasticity and Resistance to Therapies, Lille, France |
| authorships[11].author.id | https://openalex.org/A5055598987 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-5406-8981 |
| authorships[11].author.display_name | C. Trésallet |
| authorships[11].countries | FR |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I39804081, https://openalex.org/I4210121705 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of General and Endocrine Surgery - Pitié-Salpêtrière Hospital, Sorbonne University, Assistance Publique des Hôpitaux de Paris, Paris, France |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I4210091279 |
| authorships[11].affiliations[1].raw_affiliation_string | Department of Digestive, Bariatric and Endocrine Surgery - Avicenne University Hospital, Paris Nord - Sorbonne University, Assistance Publique des Hôpitaux de Paris, Paris, France |
| authorships[11].institutions[0].id | https://openalex.org/I4210121705 |
| authorships[11].institutions[0].ror | https://ror.org/02mh9a093 |
| authorships[11].institutions[0].type | healthcare |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210097159, https://openalex.org/I4210121705 |
| authorships[11].institutions[0].country_code | FR |
| authorships[11].institutions[0].display_name | Pitié-Salpêtrière Hospital |
| authorships[11].institutions[1].id | https://openalex.org/I39804081 |
| authorships[11].institutions[1].ror | https://ror.org/02en5vm52 |
| authorships[11].institutions[1].type | education |
| authorships[11].institutions[1].lineage | https://openalex.org/I39804081 |
| authorships[11].institutions[1].country_code | FR |
| authorships[11].institutions[1].display_name | Sorbonne Université |
| authorships[11].institutions[2].id | https://openalex.org/I4210091279 |
| authorships[11].institutions[2].ror | https://ror.org/0199hds37 |
| authorships[11].institutions[2].type | education |
| authorships[11].institutions[2].lineage | https://openalex.org/I4210091279 |
| authorships[11].institutions[2].country_code | FR |
| authorships[11].institutions[2].display_name | Université Sorbonne Paris Nord |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Christophe Trésallet |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Digestive, Bariatric and Endocrine Surgery - Avicenne University Hospital, Paris Nord - Sorbonne University, Assistance Publique des Hôpitaux de Paris, Paris, France, Department of General and Endocrine Surgery - Pitié-Salpêtrière Hospital, Sorbonne University, Assistance Publique des Hôpitaux de Paris, Paris, France |
| authorships[12].author.id | https://openalex.org/A5079740606 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-4726-9889 |
| authorships[12].author.display_name | Laura A. Marlow |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210146710 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States |
| authorships[12].institutions[0].id | https://openalex.org/I4210146710 |
| authorships[12].institutions[0].ror | https://ror.org/03zzw1w08 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I1330342723, https://openalex.org/I4210146710 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Mayo Clinic in Florida |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Laura A. Marlow |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States |
| authorships[13].author.id | https://openalex.org/A5091514582 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-5091-6242 |
| authorships[13].author.display_name | John A. Copland |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210146710 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States |
| authorships[13].institutions[0].id | https://openalex.org/I4210146710 |
| authorships[13].institutions[0].ror | https://ror.org/03zzw1w08 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I1330342723, https://openalex.org/I4210146710 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Mayo Clinic in Florida |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | John A. Copland |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Cancer Biology, Mayo Clinic, Jacksonville, FL, United States |
| authorships[14].author.id | https://openalex.org/A5055086811 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-1791-5915 |
| authorships[14].author.display_name | Cosimo Durante |
| authorships[14].countries | IT |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I861853513 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy |
| authorships[14].institutions[0].id | https://openalex.org/I861853513 |
| authorships[14].institutions[0].ror | https://ror.org/02be6w209 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I861853513 |
| authorships[14].institutions[0].country_code | IT |
| authorships[14].institutions[0].display_name | Sapienza University of Rome |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Cosimo Durante |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy |
| authorships[15].author.id | https://openalex.org/A5082360182 |
| authorships[15].author.orcid | |
| authorships[15].author.display_name | Carine Maenhaut |
| authorships[15].countries | BE |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I132053463 |
| authorships[15].affiliations[0].raw_affiliation_string | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[15].institutions[0].id | https://openalex.org/I132053463 |
| authorships[15].institutions[0].ror | https://ror.org/01r9htc13 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I132053463 |
| authorships[15].institutions[0].country_code | BE |
| authorships[15].institutions[0].display_name | Université Libre de Bruxelles |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Carine Maenhaut |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[16].author.id | https://openalex.org/A5065364190 |
| authorships[16].author.orcid | https://orcid.org/0000-0001-8946-8635 |
| authorships[16].author.display_name | Branca Cavaco |
| authorships[16].countries | PT |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I17129648 |
| authorships[16].affiliations[0].raw_affiliation_string | Molecular Endocrinology Group, Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisbon, Portugal |
| authorships[16].institutions[0].id | https://openalex.org/I17129648 |
| authorships[16].institutions[0].ror | https://ror.org/047xxvg44 |
| authorships[16].institutions[0].type | government |
| authorships[16].institutions[0].lineage | https://openalex.org/I17129648 |
| authorships[16].institutions[0].country_code | PT |
| authorships[16].institutions[0].display_name | Instituto Português de Oncologia de Coimbra Francisco Gentil |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Branca M. Cavaco |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Molecular Endocrinology Group, Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisbon, Portugal |
| authorships[17].author.id | https://openalex.org/A5112251348 |
| authorships[17].author.orcid | |
| authorships[17].author.display_name | Jacques E. Dumont |
| authorships[17].countries | BE |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I132053463 |
| authorships[17].affiliations[0].raw_affiliation_string | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[17].institutions[0].id | https://openalex.org/I132053463 |
| authorships[17].institutions[0].ror | https://ror.org/01r9htc13 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I132053463 |
| authorships[17].institutions[0].country_code | BE |
| authorships[17].institutions[0].display_name | Université Libre de Bruxelles |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Jacques E. Dumont |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[18].author.id | https://openalex.org/A5014123674 |
| authorships[18].author.orcid | https://orcid.org/0000-0003-3058-1021 |
| authorships[18].author.display_name | Giuseppe Costante |
| authorships[18].countries | BE |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I132053463, https://openalex.org/I2801838318 |
| authorships[18].affiliations[0].raw_affiliation_string | Departments of Endocrinology and Medical Oncology, Institut Jules Bordet Comprehensive Cancer Center – Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[18].institutions[0].id | https://openalex.org/I2801838318 |
| authorships[18].institutions[0].ror | https://ror.org/05e8s8534 |
| authorships[18].institutions[0].type | healthcare |
| authorships[18].institutions[0].lineage | https://openalex.org/I2801838318 |
| authorships[18].institutions[0].country_code | BE |
| authorships[18].institutions[0].display_name | Institut Jules Bordet |
| authorships[18].institutions[1].id | https://openalex.org/I132053463 |
| authorships[18].institutions[1].ror | https://ror.org/01r9htc13 |
| authorships[18].institutions[1].type | education |
| authorships[18].institutions[1].lineage | https://openalex.org/I132053463 |
| authorships[18].institutions[1].country_code | BE |
| authorships[18].institutions[1].display_name | Université Libre de Bruxelles |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Giuseppe Costante |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Departments of Endocrinology and Medical Oncology, Institut Jules Bordet Comprehensive Cancer Center – Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[19].author.id | https://openalex.org/A5103353308 |
| authorships[19].author.orcid | |
| authorships[19].author.display_name | Pierre P. Roger |
| authorships[19].countries | BE |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I132053463 |
| authorships[19].affiliations[0].raw_affiliation_string | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| authorships[19].institutions[0].id | https://openalex.org/I132053463 |
| authorships[19].institutions[0].ror | https://ror.org/01r9htc13 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I132053463 |
| authorships[19].institutions[0].country_code | BE |
| authorships[19].institutions[0].display_name | Université Libre de Bruxelles |
| authorships[19].author_position | last |
| authorships[19].raw_author_name | Pierre P. Roger |
| authorships[19].is_corresponding | True |
| authorships[19].raw_affiliation_strings | Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Université Libre de Bruxelles (ULB)-Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.3389/fendo.2023.1247542 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | CDK4 phosphorylation status and rational use for combining CDK4/6 and BRAF/MEK inhibition in advanced thyroid carcinomas |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-25T14:43:58.451035 |
| primary_topic.id | https://openalex.org/T12829 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9987000226974487 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Advanced Breast Cancer Therapies |
| related_works | https://openalex.org/W2899084033, https://openalex.org/W2748952813, https://openalex.org/W4391375266, https://openalex.org/W2367598447, https://openalex.org/W3170994674, https://openalex.org/W2902850283, https://openalex.org/W2057779043, https://openalex.org/W2936690186, https://openalex.org/W4387217650, https://openalex.org/W2086671864 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 3 |
| locations_count | 8 |
| best_oa_location.id | doi:10.3389/fendo.2023.1247542 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2597401208 |
| best_oa_location.source.issn | 1664-2392 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-2392 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Endocrinology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Endocrinology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fendo.2023.1247542 |
| primary_location.id | doi:10.3389/fendo.2023.1247542 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2597401208 |
| primary_location.source.issn | 1664-2392 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-2392 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Endocrinology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Endocrinology |
| primary_location.landing_page_url | https://doi.org/10.3389/fendo.2023.1247542 |
| publication_date | 2023-10-26 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2040642592, https://openalex.org/W2044715980, https://openalex.org/W6769860389, https://openalex.org/W2108668400, https://openalex.org/W4309362380, https://openalex.org/W1965175058, https://openalex.org/W4220847290, https://openalex.org/W2976988657, https://openalex.org/W2769724680, https://openalex.org/W2736254713, https://openalex.org/W1885922523, https://openalex.org/W2121619780, https://openalex.org/W2156583385, https://openalex.org/W2089655089, https://openalex.org/W2950808387, https://openalex.org/W4206127585, https://openalex.org/W2552099557, https://openalex.org/W2528767298, https://openalex.org/W2620993107, https://openalex.org/W4319826645, https://openalex.org/W1978540717, https://openalex.org/W1964471916, https://openalex.org/W2098179723, https://openalex.org/W2135752830, https://openalex.org/W2150157815, https://openalex.org/W2590110326, https://openalex.org/W4310565260, https://openalex.org/W2019517928, https://openalex.org/W1984245506, https://openalex.org/W2035925771, https://openalex.org/W1985961453, https://openalex.org/W2113630192, https://openalex.org/W2002063102, https://openalex.org/W2032153614, https://openalex.org/W2136498477, https://openalex.org/W2001828150, https://openalex.org/W2279570938, https://openalex.org/W1971381075, https://openalex.org/W2037395633, https://openalex.org/W2027855079, https://openalex.org/W2063362751, https://openalex.org/W2077945404, https://openalex.org/W2103562758, https://openalex.org/W2021341670, https://openalex.org/W2153947402, https://openalex.org/W1848939527, https://openalex.org/W2805421814, https://openalex.org/W2133174470, https://openalex.org/W2166466190, https://openalex.org/W2952481429, https://openalex.org/W2083952924, https://openalex.org/W1968713298, https://openalex.org/W2604411909, https://openalex.org/W4200343863, https://openalex.org/W2953781602, https://openalex.org/W2478132860, https://openalex.org/W3045375094, https://openalex.org/W2032120822, https://openalex.org/W2047779656, https://openalex.org/W2005983366, https://openalex.org/W1999254791, https://openalex.org/W2056495027, https://openalex.org/W4294992327, https://openalex.org/W2101879774, https://openalex.org/W2913765486, https://openalex.org/W2914546646, https://openalex.org/W2782436999, https://openalex.org/W2891128017, https://openalex.org/W2150595264, https://openalex.org/W2766581537, https://openalex.org/W2030846098, https://openalex.org/W2100738068, https://openalex.org/W2157156079, https://openalex.org/W2799372852, https://openalex.org/W2159843620, https://openalex.org/W2568050301, https://openalex.org/W2096039018, https://openalex.org/W2034749721, https://openalex.org/W2088256306, https://openalex.org/W1994107958, https://openalex.org/W2090266106, https://openalex.org/W1982245444, https://openalex.org/W2058646847, https://openalex.org/W2021019266, https://openalex.org/W2181339576, https://openalex.org/W2097632521, https://openalex.org/W2167630842, https://openalex.org/W2674753830, https://openalex.org/W2884353270, https://openalex.org/W2159058669, https://openalex.org/W4309094832, https://openalex.org/W2607761262, https://openalex.org/W3193881530, https://openalex.org/W2795875131, https://openalex.org/W2139772786, https://openalex.org/W2074653631, https://openalex.org/W2080981370, https://openalex.org/W2075589452, https://openalex.org/W2226115533, https://openalex.org/W2914373477, https://openalex.org/W3034793718, https://openalex.org/W2121155074, https://openalex.org/W3137149901, https://openalex.org/W4225011396, https://openalex.org/W4317242560, https://openalex.org/W2801407670, https://openalex.org/W2832528908, https://openalex.org/W2963699363, https://openalex.org/W2780470965, https://openalex.org/W2185718064, https://openalex.org/W4220955524, https://openalex.org/W2766016994, https://openalex.org/W3160896359, https://openalex.org/W2789574985, https://openalex.org/W3141524818, https://openalex.org/W2903803003, https://openalex.org/W3014806409, https://openalex.org/W1967902354, https://openalex.org/W2983785948, https://openalex.org/W2402797587, https://openalex.org/W1977431691, https://openalex.org/W2145150141, https://openalex.org/W3093021181, https://openalex.org/W2113134419, https://openalex.org/W4234768677 |
| referenced_works_count | 125 |
| abstract_inverted_index.A | 119, 245 |
| abstract_inverted_index.a | 108, 286, 309, 331 |
| abstract_inverted_index.11 | 192, 323 |
| abstract_inverted_index.21 | 116 |
| abstract_inverted_index.98 | 111 |
| abstract_inverted_index.In | 259 |
| abstract_inverted_index.We | 30, 91 |
| abstract_inverted_index.as | 7, 36, 308 |
| abstract_inverted_index.be | 82 |
| abstract_inverted_index.by | 93, 125, 138, 157, 266, 278 |
| abstract_inverted_index.in | 25, 107, 115, 175, 218, 238 |
| abstract_inverted_index.of | 34, 65, 104, 110, 121, 143, 161, 215, 231, 289, 300, 321 |
| abstract_inverted_index.to | 51, 131, 346 |
| abstract_inverted_index.5/7 | 239 |
| abstract_inverted_index.ATC | 184 |
| abstract_inverted_index.Our | 294 |
| abstract_inverted_index.RB1 | 226 |
| abstract_inverted_index.RNA | 126 |
| abstract_inverted_index.all | 176 |
| abstract_inverted_index.and | 49, 56, 101, 114, 128, 134, 148, 164, 167, 185, 196, 268, 285, 302 |
| abstract_inverted_index.are | 18, 342 |
| abstract_inverted_index.for | 84, 334 |
| abstract_inverted_index.gel | 95 |
| abstract_inverted_index.its | 40 |
| abstract_inverted_index.not | 236 |
| abstract_inverted_index.one | 64 |
| abstract_inverted_index.our | 322 |
| abstract_inverted_index.p16 | 205 |
| abstract_inverted_index.the | 32, 37, 61, 66, 97, 102, 252, 318, 336 |
| abstract_inverted_index.use | 320 |
| abstract_inverted_index.was | 123, 136, 154, 173, 221 |
| abstract_inverted_index.who | 341 |
| abstract_inverted_index.(RB) | 44 |
| abstract_inverted_index.(the | 228 |
| abstract_inverted_index.BrdU | 139 |
| abstract_inverted_index.CDK2 | 165 |
| abstract_inverted_index.CDK4 | 35, 98, 106, 163, 171, 201, 216, 257, 291 |
| abstract_inverted_index.been | 5 |
| abstract_inverted_index.cell | 46, 117, 144, 189, 197, 219, 260 |
| abstract_inverted_index.have | 4 |
| abstract_inverted_index.high | 204 |
| abstract_inverted_index.most | 67, 280 |
| abstract_inverted_index.step | 38 |
| abstract_inverted_index.that | 79 |
| abstract_inverted_index.tool | 333 |
| abstract_inverted_index.very | 203 |
| abstract_inverted_index.were | 209, 235 |
| abstract_inverted_index.with | 27, 146, 150, 211, 223, 264, 305, 326 |
| abstract_inverted_index.(ATC) | 58 |
| abstract_inverted_index.16/23 | 183 |
| abstract_inverted_index.18/21 | 186 |
| abstract_inverted_index.19/20 | 181 |
| abstract_inverted_index.CDK4. | 244 |
| abstract_inverted_index.PDTC, | 182 |
| abstract_inverted_index.These | 16, 272 |
| abstract_inverted_index.being | 19 |
| abstract_inverted_index.blot, | 159 |
| abstract_inverted_index.cause | 230 |
| abstract_inverted_index.could | 81, 329 |
| abstract_inverted_index.cycle | 47 |
| abstract_inverted_index.drugs | 17 |
| abstract_inverted_index.found | 237 |
| abstract_inverted_index.genes | 324 |
| abstract_inverted_index.human | 69 |
| abstract_inverted_index.lines | 145, 198, 220 |
| abstract_inverted_index.major | 72 |
| abstract_inverted_index.novel | 310 |
| abstract_inverted_index.ones. | 194 |
| abstract_inverted_index.other | 28 |
| abstract_inverted_index.study | 295 |
| abstract_inverted_index.their | 303 |
| abstract_inverted_index.these | 86 |
| abstract_inverted_index.which | 208 |
| abstract_inverted_index.(PDTC) | 55 |
| abstract_inverted_index.CDK4/6 | 1 |
| abstract_inverted_index.CDKN2A | 206 |
| abstract_inverted_index.Cyclin | 282 |
| abstract_inverted_index.Poorly | 53 |
| abstract_inverted_index.Tumors | 195 |
| abstract_inverted_index.better | 344 |
| abstract_inverted_index.breast | 14 |
| abstract_inverted_index.cancer | 188 |
| abstract_inverted_index.latter | 62 |
| abstract_inverted_index.lethal | 68 |
| abstract_inverted_index.likely | 253 |
| abstract_inverted_index.lines, | 190, 261 |
| abstract_inverted_index.lines. | 118 |
| abstract_inverted_index.prompt | 332 |
| abstract_inverted_index.tested | 20 |
| abstract_inverted_index.tumors | 240 |
| abstract_inverted_index.(n=29), | 180 |
| abstract_inverted_index.11-gene | 248 |
| abstract_inverted_index.Absence | 214 |
| abstract_inverted_index.CDK4/6i | 80, 132, 147, 224, 233, 301, 338 |
| abstract_inverted_index.E1-CDK2 | 283 |
| abstract_inverted_index.Methods | 90 |
| abstract_inverted_index.Results | 170 |
| abstract_inverted_index.Several | 75 |
| abstract_inverted_index.against | 10, 21, 313 |
| abstract_inverted_index.assays. | 141, 169 |
| abstract_inverted_index.defects | 227 |
| abstract_inverted_index.further | 297 |
| abstract_inverted_index.induced | 277 |
| abstract_inverted_index.lacking | 256 |
| abstract_inverted_index.levels, | 207 |
| abstract_inverted_index.notably | 281 |
| abstract_inverted_index.primary | 229 |
| abstract_inverted_index.profile | 100 |
| abstract_inverted_index.protein | 43 |
| abstract_inverted_index.samples | 122 |
| abstract_inverted_index.several | 22 |
| abstract_inverted_index.suggest | 78 |
| abstract_inverted_index.thyroid | 59, 88, 178, 187, 315 |
| abstract_inverted_index.tissues | 113 |
| abstract_inverted_index.tumors, | 255 |
| abstract_inverted_index.tumors. | 316 |
| abstract_inverted_index.western | 158 |
| abstract_inverted_index.without | 199, 241 |
| abstract_inverted_index.BRAF/MEK | 151 |
| abstract_inverted_index.CDK4/6i. | 52 |
| abstract_inverted_index.Estrogen | 12 |
| abstract_inverted_index.advanced | 11, 87, 314 |
| abstract_inverted_index.analyzed | 92 |
| abstract_inverted_index.assessed | 137 |
| abstract_inverted_index.cancers, | 23 |
| abstract_inverted_index.cancers. | 15, 89 |
| abstract_inverted_index.clinical | 73, 298 |
| abstract_inverted_index.detected | 174 |
| abstract_inverted_index.evidence | 77 |
| abstract_inverted_index.p16/KI67 | 327 |
| abstract_inverted_index.presence | 103 |
| abstract_inverted_index.standard | 8 |
| abstract_inverted_index.supports | 296 |
| abstract_inverted_index.treating | 85 |
| abstract_inverted_index.(CDK4/6i) | 3 |
| abstract_inverted_index.Moreover, | 317 |
| abstract_inverted_index.Treatment | 142 |
| abstract_inverted_index.activity, | 41 |
| abstract_inverted_index.activity. | 213 |
| abstract_inverted_index.arresting | 270 |
| abstract_inverted_index.complexes | 166 |
| abstract_inverted_index.developed | 247 |
| abstract_inverted_index.effective | 311 |
| abstract_inverted_index.evaluated | 156 |
| abstract_inverted_index.immediate | 347 |
| abstract_inverted_index.including | 24, 191 |
| abstract_inverted_index.intrinsic | 232 |
| abstract_inverted_index.molecular | 76 |
| abstract_inverted_index.patients, | 340 |
| abstract_inverted_index.predictor | 325 |
| abstract_inverted_index.presented | 202 |
| abstract_inverted_index.prevented | 274 |
| abstract_inverted_index.represent | 71, 330 |
| abstract_inverted_index.signature | 250 |
| abstract_inverted_index.therapies | 307 |
| abstract_inverted_index.treatment | 9, 312 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Conclusion | 293 |
| abstract_inverted_index.activation | 284 |
| abstract_inverted_index.anaplastic | 57 |
| abstract_inverted_index.associated | 210, 222 |
| abstract_inverted_index.candidates | 345 |
| abstract_inverted_index.carcinomas | 179 |
| abstract_inverted_index.clonogenic | 168 |
| abstract_inverted_index.collection | 109 |
| abstract_inverted_index.commitment | 48 |
| abstract_inverted_index.completely | 267 |
| abstract_inverted_index.complexes. | 292 |
| abstract_inverted_index.considered | 63, 83 |
| abstract_inverted_index.detectable | 242 |
| abstract_inverted_index.evaluation | 299, 328 |
| abstract_inverted_index.expression | 249 |
| abstract_inverted_index.identified | 31, 251 |
| abstract_inverted_index.inhibitors | 2, 152 |
| abstract_inverted_index.mechanisms | 276 |
| abstract_inverted_index.previously | 246 |
| abstract_inverted_index.resistance | 275 |
| abstract_inverted_index.sequencing | 127 |
| abstract_inverted_index.sub-cohort | 120 |
| abstract_inverted_index.synergized | 263 |
| abstract_inverted_index.therapies. | 29 |
| abstract_inverted_index.ATC-derived | 193 |
| abstract_inverted_index.Sensitivity | 130 |
| abstract_inverted_index.carcinomas, | 60 |
| abstract_inverted_index.challenges. | 74 |
| abstract_inverted_index.combination | 149, 304 |
| abstract_inverted_index.determining | 39 |
| abstract_inverted_index.established | 6 |
| abstract_inverted_index.insensitive | 339 |
| abstract_inverted_index.palbociclib | 262 |
| abstract_inverted_index.paradoxical | 287 |
| abstract_inverted_index.permanently | 269 |
| abstract_inverted_index.potentially | 343 |
| abstract_inverted_index.recognizing | 335 |
| abstract_inverted_index.resistance) | 234 |
| abstract_inverted_index.sensitivity | 50 |
| abstract_inverted_index.(palbociclib | 133 |
| abstract_inverted_index.abemaciclib) | 135 |
| abstract_inverted_index.combinations | 26, 273 |
| abstract_inverted_index.fresh-frozen | 112 |
| abstract_inverted_index.modification | 99 |
| abstract_inverted_index.palbociclib, | 279 |
| abstract_inverted_index.unresponsive | 254 |
| abstract_inverted_index.anti-BRAF/MEK | 306 |
| abstract_inverted_index.characterized | 124 |
| abstract_inverted_index.chemotherapy. | 348 |
| abstract_inverted_index.complementary | 319 |
| abstract_inverted_index.inactivation, | 45 |
| abstract_inverted_index.intrinsically | 337 |
| abstract_inverted_index.malignancies, | 70 |
| abstract_inverted_index.proliferative | 212 |
| abstract_inverted_index.stabilization | 288 |
| abstract_inverted_index.differentiated | 54 |
| abstract_inverted_index.insensitivity. | 225 |
| abstract_inverted_index.phosphorylated | 200, 243, 290 |
| abstract_inverted_index.proliferation. | 271 |
| abstract_inverted_index.retinoblastoma | 42 |
| abstract_inverted_index.comprehensively | 155 |
| abstract_inverted_index.electrophoresis | 96 |
| abstract_inverted_index.phosphorylation | 172, 217 |
| abstract_inverted_index.two-dimensional | 94 |
| abstract_inverted_index.characterization | 160 |
| abstract_inverted_index.phosphorylation. | 258 |
| abstract_inverted_index.Receptor-positive | 13 |
| abstract_inverted_index.immunoprecipitated | 162 |
| abstract_inverted_index.T172-phosphorylated | 105 |
| abstract_inverted_index.well-differentiated | 177 |
| abstract_inverted_index.T172-phosphorylation | 33 |
| abstract_inverted_index.dabrafenib/trametinib | 265 |
| abstract_inverted_index.immunohistochemistry. | 129 |
| abstract_inverted_index.(dabrafenib/trametinib) | 153 |
| abstract_inverted_index.incorporation/viability | 140 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5103353308, https://openalex.org/A5029595400 |
| countries_distinct_count | 5 |
| institutions_distinct_count | 20 |
| corresponding_institution_ids | https://openalex.org/I132053463 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.8675492 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |