Cedrus deodara Article Swipe
YOU?
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· 2017
· Open Access
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· DOI: https://doi.org/10.4103/ijmr.ijmr_959_16
Background & objectives: The existing antileishmanial drugs for complete cure of visceral leishmaniasis (kala-azar) are limited. The available drugs are either toxic or less effective leading to disease relapse or conversion to post-kala-azar dermal leishmaniasis. Several herbal extracts have been shown to have antileishmanial activity, but a herbal drug may not always be safe. In the present study, the extract of Cedrus deodara leaves has been standardized and tested for immunomodulatory antileishmanial activities. Methods: The extracts of C. deodara leaves with different solvents such as benzene, chloroform, ethyl acetate and methanol were made by soxhlation process. Solvents were removed under reduced pressure and temperature using rotary evaporator. The antileishmanial bioassay test was performed with in vitro maintained parasites. Immunomodulatory activity of different extracts was tested by flow cytometry. Standardization of the effective fraction was performed with Linalool as a marker compound through reverse-phase high-performance liquid chromatography. Results: The extract with the use of benzene solvent showed strong antileishmanial activities within a dose 25-200 μg/ml culture with non-significant haemolytic activities and significant immunomodulant activities against the host cells. Linalool was found to be 1.29 per cent in the effective extract of C. deodara . Interpretation & conclusions: The antileishmanial activity of C. deodara , as assessed by bioassay testing on Leishmania donovani parasites and immunomodulatory effect of benzene extract of leaves on host cells indicated that it might be a potential new safe therapeutic target to cure the visceral leishmaniasis.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/ijmr.ijmr_959_16
- OA Status
- diamond
- Cited By
- 9
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2797139264
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2797139264Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.4103/ijmr.ijmr_959_16Digital Object Identifier
- Title
-
Cedrus deodaraWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-12-01Full publication date if available
- Authors
-
Shyam Narayan, Chandreshwar Prasad Thakur, Shiv Bahadur, Meenakshi Thakur, Shashi Pandey, Ajit Kumar Thakur, Dipendra Kumar Mitra, Pulok K. MukherjeeList of authors in order
- Landing page
-
https://doi.org/10.4103/ijmr.ijmr_959_16Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.4103/ijmr.ijmr_959_16Direct OA link when available
- Concepts
-
Linalool, Ethyl acetate, Visceral leishmaniasis, Bioassay, Leishmaniasis, Traditional medicine, Pharmacology, Chemistry, Amastigote, Chloroform, Leishmania, Leishmania major, In vitro, Chromatography, Medicine, Biology, Immunology, Biochemistry, Parasite hosting, Essential oil, Genetics, Computer science, World Wide WebTop concepts (fields/topics) attached by OpenAlex
- Cited by
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9Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 3, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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28Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.existing | 4 |
| abstract_inverted_index.extracts | 37, 75, 122 |
| abstract_inverted_index.fraction | 132 |
| abstract_inverted_index.limited. | 15 |
| abstract_inverted_index.methanol | 90 |
| abstract_inverted_index.pressure | 101 |
| abstract_inverted_index.process. | 95 |
| abstract_inverted_index.solvents | 82 |
| abstract_inverted_index.visceral | 11, 237 |
| abstract_inverted_index.activity, | 44 |
| abstract_inverted_index.available | 17 |
| abstract_inverted_index.different | 81, 121 |
| abstract_inverted_index.effective | 24, 131, 187 |
| abstract_inverted_index.indicated | 223 |
| abstract_inverted_index.parasites | 211 |
| abstract_inverted_index.performed | 112, 134 |
| abstract_inverted_index.potential | 229 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Leishmania | 209 |
| abstract_inverted_index.activities | 158, 168, 172 |
| abstract_inverted_index.conversion | 30 |
| abstract_inverted_index.cytometry. | 127 |
| abstract_inverted_index.haemolytic | 167 |
| abstract_inverted_index.maintained | 116 |
| abstract_inverted_index.parasites. | 117 |
| abstract_inverted_index.soxhlation | 94 |
| abstract_inverted_index.(kala-azar) | 13 |
| abstract_inverted_index.activities. | 72 |
| abstract_inverted_index.chloroform, | 86 |
| abstract_inverted_index.evaporator. | 106 |
| abstract_inverted_index.objectives: | 2 |
| abstract_inverted_index.significant | 170 |
| abstract_inverted_index.temperature | 103 |
| abstract_inverted_index.therapeutic | 232 |
| abstract_inverted_index.conclusions: | 195 |
| abstract_inverted_index.standardized | 66 |
| abstract_inverted_index.leishmaniasis | 12 |
| abstract_inverted_index.reverse-phase | 142 |
| abstract_inverted_index.Interpretation | 193 |
| abstract_inverted_index.immunomodulant | 171 |
| abstract_inverted_index.leishmaniasis. | 34, 238 |
| abstract_inverted_index.post-kala-azar | 32 |
| abstract_inverted_index.Standardization | 128 |
| abstract_inverted_index.antileishmanial | 5, 43, 71, 108, 157, 197 |
| abstract_inverted_index.chromatography. | 145 |
| abstract_inverted_index.non-significant | 166 |
| abstract_inverted_index.Immunomodulatory | 118 |
| abstract_inverted_index.high-performance | 143 |
| abstract_inverted_index.immunomodulatory | 70, 213 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6299999952316284 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.67345008 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |