Cell contractility drives mechanical memory of oral squamous cell carcinoma Article Swipe

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So Youn Moon , Paloma Santos de Campos , Bibiana Franzen Matte , Jesse K. Placone , Virgı ́lio G. Zanella , Manoela Domingues Martins , Marcelo Lazzaron Lamers , Adam J. Engler ·

YOU? · · 2023 · Open Access · · DOI: https://doi.org/10.1091/mbc.e22-07-0266

Oral cancer cells sense and respond to matrix stiffness via myosin contractility. As part of their response, they use AKT and FAK signaling to retain and recall the ‘memory’ developed within the tumor core to remain highly migratory and mesenchymal in tumor adjacent epithelium, despite being significantly softer.

Related Topics

Biology

Cell Biology

Phenotype

Mesenchymal Stem Cell

Concepts

Biology Cell biology Phenotype Focal adhesion Contractility Mesenchymal stem cell Myosin Cell Epithelial–mesenchymal transition Cancer research Protein kinase B Signal transduction Cancer Metastasis Endocrinology Genetics Gene

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Type: article
Language: en
Landing Page: https://doi.org/10.1091/mbc.e22-07-0266
OA Status: green
Cited By: 17
References: 76
Related Works: 10
OpenAlex ID: https://openalex.org/W4381490520

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OpenAlex ID: https://openalex.org/W4381490520

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DOI: https://doi.org/10.1091/mbc.e22-07-0266

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Title: Cell contractility drives mechanical memory of oral squamous cell carcinoma

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Type: article

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Language: en

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Publication year: 2023

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Publication date: 2023-06-21

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Authors: So Youn Moon, Paloma Santos de Campos, Bibiana Franzen Matte, Jesse K. Placone, Virgı ́lio G. Zanella, Manoela Domingues Martins, Marcelo Lazzaron Lamers, Adam J. Engler

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Landing page: https://doi.org/10.1091/mbc.e22-07-0266

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Open access: Yes

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OA status: green

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OA URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10398896/pdf/mbc-34-ar89.pdf

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Concepts: Biology, Cell biology, Phenotype, Focal adhesion, Contractility, Mesenchymal stem cell, Myosin, Cell, Epithelial–mesenchymal transition, Cancer research, Protein kinase B, Signal transduction, Cancer, Metastasis, Endocrinology, Genetics, Gene

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Cited by: 17

Total citation count in OpenAlex
Citations by year (recent): 2025: 8, 2024: 7, 2023: 2

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References (count): 76

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Related works (count): 10

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