Cell‐free DNA for detection of clonal B cells in diffuse large B cell lymphoma by sequencing
Article Swipe
Elisabeth Luna Højlund
,
Oriane Cédile
,
Thomas Stauffer Larsen
,
Gayaththri Vimalathas
,
Michael Møller
,
Marcus Høy Hansen
,
Charlotte Guldborg Nyvold
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/ijlh.14116
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1111/ijlh.14116
Introduction Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma in the western world. It is highly heterogeneous with a variable clinical course, but curable with chemo‐immunotherapy in up to 70% of all cases. The lymphoma presents in lymph nodes and/or extranodal lymphoid tissue, and the diagnosis is based on invasive procedures for histopathologic evaluation. Methods In this technical study, we evaluated cell‐free DNA (cfDNA) from blood plasma to detect clonal B cells in patients with DLBCL using rearranged immunoglobulin heavy chain gene as targets by next‐generation sequencing. Clonal B cell sequences and frequencies were determined from blood plasma cfDNA and cellular DNA from matched excised lymphoma tissues and mononuclear cells isolated from diagnostic bone marrow and blood samples from 15 patients. Results We showed that identical clonal rearrangements could be detected in blood plasma and excised lymphoma tissue and that plasma cfDNA was superior in detecting clonal rearrangements compared to blood or bone marrow‐derived cellular DNA. Conclusion These findings consolidate the role of blood plasma as a reliable and easily accessible source for detecting neoplastic cells in DLBCL.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/ijlh.14116
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ijlh.14116
- OA Status
- hybrid
- Cited By
- 1
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4381716531
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4381716531Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/ijlh.14116Digital Object Identifier
- Title
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Cell‐free
DNA for detection of clonal B cells in diffuse large B cell lymphoma by sequencingWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-06-22Full publication date if available
- Authors
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Elisabeth Luna Højlund, Oriane Cédile, Thomas Stauffer Larsen, Gayaththri Vimalathas, Michael Møller, Marcus Høy Hansen, Charlotte Guldborg NyvoldList of authors in order
- Landing page
-
https://doi.org/10.1111/ijlh.14116Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ijlh.14116Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ijlh.14116Direct OA link when available
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Diffuse large B-cell lymphoma, DNA, Lymphoma, B cell, Cell, Molecular biology, DNA sequencing, Computational biology, Biology, Genetics, Immunology, AntibodyTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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