CellKine clinical trial: first report from a phase 1 trial of allogeneic bone marrow–derived mesenchymal stem cells in subjects with painful lumbar facet joint arthropathy Article Swipe
Dan Yan
,
Abba C. Zubair
,
Michael D. Osborne
,
Robert Pagan‐Rosado
,
Jeffrey A. Stone
,
Vance T. Lehman
,
Nisha Durand
,
Eva Kubrova
,
Zhen Wang
,
D. M. Witter
,
Meghan M. Baer
,
Gabriela C. Ponce
,
Alfredo Quiñones‐Hinojosa
,
Wenchun Qu
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1097/pr9.0000000000001181
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1097/pr9.0000000000001181
Background: Lumbar facet joint arthropathy (LFJA) is a major cause of low back pain (LBP), with current treatments offering limited long-term benefits. Bone marrow–derived mesenchymal stem cells (BM-MSCs) show promise due to their immunomodulatory and trophic effects, potentially addressing underlying degenerative processes in LFJA. Objectives: This initial report describes the outcomes of the first treated patient in an ongoing mutidisciplinary phase 1 clinical trial evaluating the safety and feasibility of intra-articular allogeneic BM-MSCs for painful LFJA. Methods: Following enrollment in our IRB-approved protocol, symptomatic LFJA was confirmed through double blocks on L4 and L5 medial branches. Two 1-mL syringes, each containing 10 million BM-MSCs, were prepared in the cGMP facility and administered bilaterally to the patient’s L4-L5 lumbar facet joints. The patient underwent standardized follow-ups, including clinical examinations and functional and imaging assessments for 2 years, utilizing patient-reported outcomes measurement information system—computer adaptive tests (PROMIS CATs), visual analogue scale, Oswestry disability index, work functional status and opioid pain medication use, and MR imaging Fenton–Czervionke score. Results: The patient tolerated the procedure well, with no drug-related adverse events during the study period. Pain, spine function, and work functional status improved at multiple follow-ups. This patient also reported improvements in mental and social health, along with a notable improvement in the grade of facet synovitis observed at the one-year follow-up MRI evaluation. Conclusions: This case report suggests the safety and feasibility of administering intra-articular allogeneic BM-MSCs, offering therapeutic benefits for pain management and functional activities.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/pr9.0000000000001181
- OA Status
- gold
- Cited By
- 2
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402635288
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402635288Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/pr9.0000000000001181Digital Object Identifier
- Title
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CellKine clinical trial: first report from a phase 1 trial of allogeneic bone marrow–derived mesenchymal stem cells in subjects with painful lumbar facet joint arthropathyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-09-18Full publication date if available
- Authors
-
Dan Yan, Abba C. Zubair, Michael D. Osborne, Robert Pagan‐Rosado, Jeffrey A. Stone, Vance T. Lehman, Nisha Durand, Eva Kubrova, Zhen Wang, D. M. Witter, Meghan M. Baer, Gabriela C. Ponce, Alfredo Quiñones‐Hinojosa, Wenchun QuList of authors in order
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https://doi.org/10.1097/pr9.0000000000001181Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1097/pr9.0000000000001181Direct OA link when available
- Concepts
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Medicine, Mesenchymal stem cell, Visual analogue scale, Lumbar, Adverse effect, Low back pain, Facet joint, Clinical trial, Surgery, Physical therapy, Internal medicine, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2Per-year citation counts (last 5 years)
- References (count)
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54Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.disability | 151 |
| abstract_inverted_index.enrollment | 79 |
| abstract_inverted_index.evaluating | 65 |
| abstract_inverted_index.functional | 130, 154, 187, 242 |
| abstract_inverted_index.management | 240 |
| abstract_inverted_index.medication | 159 |
| abstract_inverted_index.treatments | 18 |
| abstract_inverted_index.underlying | 40 |
| abstract_inverted_index.Background: | 1 |
| abstract_inverted_index.Objectives: | 45 |
| abstract_inverted_index.activities. | 243 |
| abstract_inverted_index.arthropathy | 5 |
| abstract_inverted_index.assessments | 133 |
| abstract_inverted_index.bilaterally | 113 |
| abstract_inverted_index.evaluation. | 220 |
| abstract_inverted_index.feasibility | 69, 229 |
| abstract_inverted_index.follow-ups, | 125 |
| abstract_inverted_index.follow-ups. | 192 |
| abstract_inverted_index.improvement | 207 |
| abstract_inverted_index.information | 141 |
| abstract_inverted_index.measurement | 140 |
| abstract_inverted_index.mesenchymal | 25 |
| abstract_inverted_index.patient’s | 116 |
| abstract_inverted_index.potentially | 38 |
| abstract_inverted_index.symptomatic | 84 |
| abstract_inverted_index.therapeutic | 236 |
| abstract_inverted_index.Conclusions: | 221 |
| abstract_inverted_index.IRB-approved | 82 |
| abstract_inverted_index.administered | 112 |
| abstract_inverted_index.degenerative | 41 |
| abstract_inverted_index.drug-related | 175 |
| abstract_inverted_index.examinations | 128 |
| abstract_inverted_index.improvements | 197 |
| abstract_inverted_index.standardized | 124 |
| abstract_inverted_index.administering | 231 |
| abstract_inverted_index.intra-articular | 71, 232 |
| abstract_inverted_index.immunomodulatory | 34 |
| abstract_inverted_index.marrow–derived | 24 |
| abstract_inverted_index.mutidisciplinary | 60 |
| abstract_inverted_index.patient-reported | 138 |
| abstract_inverted_index.system—computer | 142 |
| abstract_inverted_index.Fenton–Czervionke | 164 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 14 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/4 |
| sustainable_development_goals[0].score | 0.4099999964237213 |
| sustainable_development_goals[0].display_name | Quality Education |
| citation_normalized_percentile.value | 0.79458591 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |