Central Nervous System Virus Infection in African Children with Cerebral Malaria Article Swipe
Douglas G. Postels
,
Lawrence Osei‐Tutu
,
Karl B. Seydel
,
Qian Xu
,
Chenxi Li
,
Terrie E. Taylor
,
Chandy C. John
,
Macpherson Mallewa
,
Tom Solomon
,
Tsiri Agbenyega
,
Daniel Ansong
,
Robert O. Opoka
,
Lillian M. Khan
,
Prashanth Ramachandran
,
Kristoffer E. Leon
,
Joseph L. DeRisi
,
Charles Langelier
,
Michael R. Wilson
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4269/ajtmh.19-0962
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4269/ajtmh.19-0962
We aimed to identify the contribution of central nervous system (CNS) viral coinfection to illness in African children with retinopathy-negative or retinopathy-positive cerebral malaria (CM). We collected cerebrospinal fluid (CSF) from 272 children with retinopathy-negative or retinopathy-positive CM and selected CSF from 111 of these children (38 retinopathy positive, 71 retinopathy negative, 2 retinopathy unknown) for analysis by metagenomic next-generation sequencing. We found CSF viral coinfections in 7/38 (18.4%) retinopathy-positive children and in 18/71 (25.4%) retinopathy-negative children. Excluding HIV-1, human herpesviruses (HHV) represented 61% of viruses identified. Excluding HIV-1, CNS viral coinfection was equally likely in children who were retinopathy positive and retinopathy negative (P = 0.1431). Neither mortality nor neurological morbidity was associated with the presence of virus (odds ratio [OR] = 0.276, 95% CI: 0.056-1.363). Retinopathy-negative children with a higher temperature, lower white blood cell count, or being dehydrated were more likely to have viral coinfection. Level of consciousness at admission was not associated with CNS viral coinfection in retinopathy-negative children. Viral CNS coinfection is unlikely to contribute to coma in children with CM. The herpesviruses other than herpes simplex virus may represent incidental bystanders in CM, reactivating during acute malaria infection.
Related Topics
Concepts
Coinfection
Retinopathy
Medicine
Cerebral Malaria
Odds ratio
Immunology
Retinopathy of prematurity
Virology
Virus
Malaria
Biology
Internal medicine
Plasmodium falciparum
Gestational age
Pregnancy
Diabetes mellitus
Genetics
Endocrinology
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4269/ajtmh.19-0962
- https://www.ajtmh.org/downloadpdf/journals/tpmd/103/1/article-p200.pdf
- OA Status
- bronze
- Cited By
- 12
- References
- 23
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3020143400
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3020143400Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.4269/ajtmh.19-0962Digital Object Identifier
- Title
-
Central Nervous System Virus Infection in African Children with Cerebral MalariaWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-04-28Full publication date if available
- Authors
-
Douglas G. Postels, Lawrence Osei‐Tutu, Karl B. Seydel, Qian Xu, Chenxi Li, Terrie E. Taylor, Chandy C. John, Macpherson Mallewa, Tom Solomon, Tsiri Agbenyega, Daniel Ansong, Robert O. Opoka, Lillian M. Khan, Prashanth Ramachandran, Kristoffer E. Leon, Joseph L. DeRisi, Charles Langelier, Michael R. WilsonList of authors in order
- Landing page
-
https://doi.org/10.4269/ajtmh.19-0962Publisher landing page
- PDF URL
-
https://www.ajtmh.org/downloadpdf/journals/tpmd/103/1/article-p200.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://www.ajtmh.org/downloadpdf/journals/tpmd/103/1/article-p200.pdfDirect OA link when available
- Concepts
-
Coinfection, Retinopathy, Medicine, Cerebral Malaria, Odds ratio, Immunology, Retinopathy of prematurity, Virology, Virus, Malaria, Biology, Internal medicine, Plasmodium falciparum, Gestational age, Pregnancy, Diabetes mellitus, Genetics, EndocrinologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
12Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 2, 2023: 1, 2022: 2, 2021: 4Per-year citation counts (last 5 years)
- References (count)
-
23Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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