Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approach Article Swipe
Luigi Maione
,
Claire Bouvattier
,
Ursula B. Kaiser
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/cen.14475
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/cen.14475
Central precocious puberty (CPP) results from early activation of the hypothalamic‐pituitary‐gonadal (HPG) axis. The current state of knowledge of the complex neural network acting at the level of the hypothalamus and the GnRH neuron to control puberty onset has expanded, particularly in the context of molecular interactions. Along with these advances, the knowledge of pubertal physiology and pathophysiology has also increased. This review focuses on regulatory abnormalities occurring at the hypothalamic level of the HPG axis to cause CPP. The clinical approach to diagnosis of puberty and pubertal disorders is also reviewed, with a particular focus on aetiologies of CPP. The recent identification of mutations in MKRN3 and DLK1 in familial as well sporadic forms of CPP has changed the state of the art of the approach to patients with CPP. Genetic advances have also had important repercussions beyond consideration of puberty alone. Syndromic disorders and central nervous system lesions associated with CPP are also discussed. If untreated, these conditions may lead to adverse physical, psychosocial and medical outcomes.
Related Topics
Concepts
Precocious puberty
Context (archaeology)
Central precocious puberty
Medicine
Etiology
Psychosocial
Central nervous system
Endocrinology
Internal medicine
Hypothalamus
Hypothalamic–pituitary–gonadal axis
Neuroscience
Bioinformatics
Psychology
Hormone
Biology
Psychiatry
Luteinizing hormone
Paleontology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/cen.14475
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cen.14475
- OA Status
- bronze
- Cited By
- 84
- References
- 108
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3146565417
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3146565417Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/cen.14475Digital Object Identifier
- Title
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Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approachWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-04-02Full publication date if available
- Authors
-
Luigi Maione, Claire Bouvattier, Ursula B. KaiserList of authors in order
- Landing page
-
https://doi.org/10.1111/cen.14475Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cen.14475Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cen.14475Direct OA link when available
- Concepts
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Precocious puberty, Context (archaeology), Central precocious puberty, Medicine, Etiology, Psychosocial, Central nervous system, Endocrinology, Internal medicine, Hypothalamus, Hypothalamic–pituitary–gonadal axis, Neuroscience, Bioinformatics, Psychology, Hormone, Biology, Psychiatry, Luteinizing hormone, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
84Total citation count in OpenAlex
- Citations by year (recent)
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2025: 19, 2024: 24, 2023: 23, 2022: 12, 2021: 5Per-year citation counts (last 5 years)
- References (count)
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108Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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