Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin Article Swipe
Guifeng Su
,
Dan Wang
,
Qianqing Yang
,
Lingmei Kong
,
Xiaoman Ju
,
Qihong Yang
,
Yiying Zhu
,
Shaohua Zhang
,
Yan Li
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s13659-024-00443-1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1007/s13659-024-00443-1
The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various carcinomas, especially colorectal cancers (CRCs), where adenomatous colorectal polyposis (APC) mutations are the most frequently observed, which limits the anti-tumor efficiency of inhibitors targeting the upstream of Wnt/β-catenin pathway. The anti-tumor activity of the naturally occurring alkaloid cepharanthine (CEP) extracted from the plant Stephania cepharantha Hayata has been reported in various types of tumors. We previously observed that its derivatives inhibited the Wnt/β-catenin signaling in liver cancer; however, the specific mechanism remains unknown. In this study, we confirmed CEP can effectively inhibit APC -mutant CRC cell lines (SW480, SW620, LoVo) through disturbing of the Wnt/β-catenin signaling and elucidated the underlying mechanisms. Here, we demonstrate that CEP attenuates the Wnt/β-catenin signaling by decreasing the β-catenin, subsequently impeding the proliferation of APC -mutant CRCs. Moreover, CEP induced β-catenin transcription inhibition rather than the instability of β-catenin protein and mRNA contributes to reduction of β-catenin. Taken together, our findings identify CEP as the first β-catenin transcriptional inhibitor in the modulation of Wnt/β-catenin signaling and indicate CEP as a potential therapeutic option for the treatment of APC -mutated CRCs. Graphical Abstract
Related Topics
Concepts
Wnt signaling pathway
Adenomatous polyposis coli
Catenin
Colorectal cancer
Cancer research
Beta-catenin
Mutant
Signal transduction
Biology
Cell growth
Chemistry
Cancer
Cell biology
Biochemistry
Genetics
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s13659-024-00443-1
- https://link.springer.com/content/pdf/10.1007/s13659-024-00443-1.pdf
- OA Status
- diamond
- Cited By
- 6
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392283734
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392283734Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s13659-024-00443-1Digital Object Identifier
- Title
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Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-cateninWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-02-29Full publication date if available
- Authors
-
Guifeng Su, Dan Wang, Qianqing Yang, Lingmei Kong, Xiaoman Ju, Qihong Yang, Yiying Zhu, Shaohua Zhang, Yan LiList of authors in order
- Landing page
-
https://doi.org/10.1007/s13659-024-00443-1Publisher landing page
- PDF URL
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https://link.springer.com/content/pdf/10.1007/s13659-024-00443-1.pdfDirect link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s13659-024-00443-1.pdfDirect OA link when available
- Concepts
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Wnt signaling pathway, Adenomatous polyposis coli, Catenin, Colorectal cancer, Cancer research, Beta-catenin, Mutant, Signal transduction, Biology, Cell growth, Chemistry, Cancer, Cell biology, Biochemistry, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
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2025: 4, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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53Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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