Cerebral perfusion and amyloidosis in the oldest‐old Article Swipe
Shubir Dutt
,
Davis C. Woodworth
,
S. Ahmad Sajjadi
,
Claudia H. Kawas
,
María M. Corrada
,
Daniel A. Nation
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/alz.079163
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/alz.079163
Background Cerebrovascular contributions to cognitive aging and Alzheimer’s disease (AD) risk represent a growing field in aging research. Studies in the young‐old have demonstrated the critical role of vascular dysregulation (i.e., altered cerebral blood flow) in relation to cognitive decline prior to the appearance of amyloid/tau biomarkers. However, cerebral perfusion has not been well‐studied in the oldest‐old (ages 90 and over), a rapidly growing population that may provide unique insight into resilience and protective factors against dementia in later life. We characterized amyloid and cerebral perfusion profiles of cognitively normal (CN) and cognitively impaired without dementia (CIND) oldest‐old individuals. Method Participants were 97 dementia‐free older adults (70 CN and 27 CIND) from the 90+ Study who had available neuroimaging (T1‐MRI, ASL‐MRI, Florbetapir‐PET), demographic, and clinical data. We examined differences between CN and CIND in regional perfusion in areas associated with AD risk (medial temporal lobe, posterior cingulate, precuneus, frontal cortex, inferior parietal lobe) and in amyloid burden using linear regression models controlling for age, sex, education, APOE4 status, and vascular risk factors. Result CN and CIND groups did not differ in the characteristics compared (Table 1). CIND participants had lower CBF in the posterior cingulate/precuneus than the CN group, but groups did not differ in posterior cingulate/precuneus amyloid SUVR (Figure 1). Additionally, CIND had lower CBF than CN in the inferior parietal lobe but higher CBF in the medial temporal lobe and orbitofrontal cortex (Figure 2). Conclusion CIND individuals had lower regional perfusion in the posterior cingulate/precuneus, but groups did not differ in amyloidosis, highlighting the relationship between cerebrovascular function and cognitive status in the oldest‐old independent of amyloidosis. Our findings complement previously reported posterior cingulate/precuneus hypoperfusion in younger‐old individuals with cognitive impairment and AD. Interestingly, we observed greater medial temporal/frontal perfusion in CIND than CN, similar to previous studies demonstrating initial hyperperfusion preceding hypoperfusion across the CN‐CIND‐Dementia spectrum. This may represent a compensatory vascular mechanism supporting cognition in individuals at greater risk of developing dementia. Future studies will further characterize this cohort with longitudinal perfusion analyses, neuropsychological correlates, and relationships between perfusion and other indices of cerebrovascular dysfunction.
Related Topics
Concepts
Precuneus
Posterior cingulate
Dementia
Medicine
Temporal lobe
Cognitive decline
Internal medicine
Cerebral blood flow
Cardiology
Psychology
Population
Orbitofrontal cortex
Neuroscience
Cortex (anatomy)
Cognition
Disease
Prefrontal cortex
Epilepsy
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/alz.079163
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.079163
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390199559
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390199559Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/alz.079163Digital Object Identifier
- Title
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Cerebral perfusion and amyloidosis in the oldest‐oldWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-12-01Full publication date if available
- Authors
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Shubir Dutt, Davis C. Woodworth, S. Ahmad Sajjadi, Claudia H. Kawas, María M. Corrada, Daniel A. NationList of authors in order
- Landing page
-
https://doi.org/10.1002/alz.079163Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.079163Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.079163Direct OA link when available
- Concepts
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Precuneus, Posterior cingulate, Dementia, Medicine, Temporal lobe, Cognitive decline, Internal medicine, Cerebral blood flow, Cardiology, Psychology, Population, Orbitofrontal cortex, Neuroscience, Cortex (anatomy), Cognition, Disease, Prefrontal cortex, Epilepsy, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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