Cerebral perfusion pressure targets after traumatic brain injury: a reappraisal Article Swipe
Stefan Yu Bögli
,
Ihsane Olakorede
,
Erta Beqiri
,
Xuhang Chen
,
Andrea Lavinio
,
Peter J. Hutchinson
,
Peter Smielewski
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s13054-025-05458-9
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s13054-025-05458-9
Introduction Cerebral perfusion pressure (CPP) management is central to neurocritical care management after traumatic brain injury (TBI). While the Brain Trauma Foundation recommends a target of 60–70 mmHg, it is unclear whether this range reflects the lower limit or the optimal level, when viewed through the prism of cerebrovascular autoregulation. Autoregulation aims at stabilizing cerebral blood flow and can be estimated continuously using the pressure reactivity index (PRx). Personalized CPP targets can be derived from PRx including CPPopt (optimal CPP), LLA, and ULA (lower and upper limit of autoregulation). Emerging data suggests an asymmetric relationship around CPPopt, with more pronounced autoregulation deterioration with decreasing compared to increasing CPP. Based on the hypothesis that higher CPP levels may be less harmful than lower CPP levels, we aimed to reassess rigorously the prognostic value of the different CPP targets. Material and methods We analyzed 809 adult TBI patients admitted from 2002 to 2023 who underwent invasive intracranial pressure monitoring and had available 6-month outcomes. CPPopt, LLA, and ULA were estimated using previously published methodologies. Deviations of CPP from fixed or personalized targets were assessed describing the overall dose, the hourly dose and the percentage time spent outside of these targets and examined using Chi-squared tests, logistic regressions, heatmaps, ordinal analyses, and group-based trajectory modelling. Results Our data confirms an asymmetric CPP/PRx relationship with steeper increases in PRx with decreasing and only modest elevations with increasing CPP. Even small decreases below CPPopt were consistently linked to worse outcomes (OR 1.04 (CI 1.02–1.06) and 1.09 (CI 1.04–1.15) for hourly dose and percentage time spent below CPPopt, p < 0.001 and p = 0.001 respectively). The strength of association increased with further decreases in CPP away from CPPopt towards the LLA with OR of 1.11 (CI 1.07–1.14) and 1.26 (CI 1.18–1.35) for hourly dose and percentage time spent below LLA respectively ( p < 0.001). Conversely, higher-than CPPopt levels generally showed no association to worse outcomes. Distinct trajectories in the relationship between CPPopt and LLA (introduced as the Lower Limit Margin) could be identified with worse outcomes in those with decreasing distance between these targets (Mortality of 18% vs. 45% for patients with increasing vs. decreasing lower limit margins, p = 0.003). Conclusion Our findings corroborate experimental work suggesting that TBI patients are more vulnerable to CPP reductions below as compared to elevations above personalized thresholds. The results highlight the need for individualized CPP management strategies that prioritize avoidance of lower CPP levels and suggest using CPPopt as the lower CPP limit.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s13054-025-05458-9
- https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05458-9
- OA Status
- gold
- Cited By
- 10
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410588478
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4410588478Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s13054-025-05458-9Digital Object Identifier
- Title
-
Cerebral perfusion pressure targets after traumatic brain injury: a reappraisalWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-21Full publication date if available
- Authors
-
Stefan Yu Bögli, Ihsane Olakorede, Erta Beqiri, Xuhang Chen, Andrea Lavinio, Peter J. Hutchinson, Peter SmielewskiList of authors in order
- Landing page
-
https://doi.org/10.1186/s13054-025-05458-9Publisher landing page
- PDF URL
-
https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05458-9Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05458-9Direct OA link when available
- Concepts
-
Medicine, Autoregulation, Traumatic brain injury, Cerebral autoregulation, Cerebral perfusion pressure, Cerebral blood flow, Neurointensive care, Anesthesia, Perfusion, Internal medicine, Blood pressure, Emergency medicine, Cardiology, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 10Per-year citation counts (last 5 years)
- References (count)
-
50Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4410588478 |
|---|---|
| doi | https://doi.org/10.1186/s13054-025-05458-9 |
| ids.doi | https://doi.org/10.1186/s13054-025-05458-9 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40399968 |
| ids.openalex | https://openalex.org/W4410588478 |
| fwci | 45.52171481 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000503 |
| mesh[1].descriptor_ui | D000070642 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | physiopathology |
| mesh[1].descriptor_name | Brain Injuries, Traumatic |
| mesh[2].qualifier_ui | Q000150 |
| mesh[2].descriptor_ui | D000070642 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | complications |
| mesh[2].descriptor_name | Brain Injuries, Traumatic |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D008297 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Male |
| mesh[4].qualifier_ui | Q000502 |
| mesh[4].descriptor_ui | D002560 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | physiology |
| mesh[4].descriptor_name | Cerebrovascular Circulation |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D000328 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Adult |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D008875 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Middle Aged |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D005260 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Female |
| mesh[8].qualifier_ui | Q000502 |
| mesh[8].descriptor_ui | D007427 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | physiology |
| mesh[8].descriptor_name | Intracranial Pressure |
| mesh[9].qualifier_ui | Q000502 |
| mesh[9].descriptor_ui | D006706 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | physiology |
| mesh[9].descriptor_name | Homeostasis |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D000368 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Aged |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D012189 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Retrospective Studies |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D006801 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Humans |
| mesh[13].qualifier_ui | Q000503 |
| mesh[13].descriptor_ui | D000070642 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | physiopathology |
| mesh[13].descriptor_name | Brain Injuries, Traumatic |
| mesh[14].qualifier_ui | Q000150 |
| mesh[14].descriptor_ui | D000070642 |
| mesh[14].is_major_topic | True |
| mesh[14].qualifier_name | complications |
| mesh[14].descriptor_name | Brain Injuries, Traumatic |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D008297 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Male |
| mesh[16].qualifier_ui | Q000502 |
| mesh[16].descriptor_ui | D002560 |
| mesh[16].is_major_topic | True |
| mesh[16].qualifier_name | physiology |
| mesh[16].descriptor_name | Cerebrovascular Circulation |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D000328 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Adult |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D008875 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Middle Aged |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D005260 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Female |
| mesh[20].qualifier_ui | Q000502 |
| mesh[20].descriptor_ui | D007427 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | physiology |
| mesh[20].descriptor_name | Intracranial Pressure |
| mesh[21].qualifier_ui | Q000502 |
| mesh[21].descriptor_ui | D006706 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | physiology |
| mesh[21].descriptor_name | Homeostasis |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D000368 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Aged |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D012189 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Retrospective Studies |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D006801 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Humans |
| mesh[25].qualifier_ui | Q000503 |
| mesh[25].descriptor_ui | D000070642 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | physiopathology |
| mesh[25].descriptor_name | Brain Injuries, Traumatic |
| mesh[26].qualifier_ui | Q000150 |
| mesh[26].descriptor_ui | D000070642 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | complications |
| mesh[26].descriptor_name | Brain Injuries, Traumatic |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D008297 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Male |
| mesh[28].qualifier_ui | Q000502 |
| mesh[28].descriptor_ui | D002560 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | physiology |
| mesh[28].descriptor_name | Cerebrovascular Circulation |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D000328 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Adult |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D008875 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Middle Aged |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D005260 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Female |
| mesh[32].qualifier_ui | Q000502 |
| mesh[32].descriptor_ui | D007427 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | physiology |
| mesh[32].descriptor_name | Intracranial Pressure |
| mesh[33].qualifier_ui | Q000502 |
| mesh[33].descriptor_ui | D006706 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | physiology |
| mesh[33].descriptor_name | Homeostasis |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D000368 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Aged |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D012189 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Retrospective Studies |
| mesh[36].qualifier_ui | Q000175 |
| mesh[36].descriptor_ui | D000070642 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | diagnosis |
| mesh[36].descriptor_name | Brain Injuries, Traumatic |
| mesh[37].qualifier_ui | Q000188 |
| mesh[37].descriptor_ui | D000070642 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | drug therapy |
| mesh[37].descriptor_name | Brain Injuries, Traumatic |
| mesh[38].qualifier_ui | Q000503 |
| mesh[38].descriptor_ui | D000070642 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | physiopathology |
| mesh[38].descriptor_name | Brain Injuries, Traumatic |
| mesh[39].qualifier_ui | Q000187 |
| mesh[39].descriptor_ui | D002560 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | drug effects |
| mesh[39].descriptor_name | Cerebrovascular Circulation |
| mesh[40].qualifier_ui | Q000502 |
| mesh[40].descriptor_ui | D002560 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | physiology |
| mesh[40].descriptor_name | Cerebrovascular Circulation |
| mesh[41].qualifier_ui | Q000187 |
| mesh[41].descriptor_ui | D007427 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | drug effects |
| mesh[41].descriptor_name | Intracranial Pressure |
| mesh[42].qualifier_ui | Q000502 |
| mesh[42].descriptor_ui | D007427 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | physiology |
| mesh[42].descriptor_name | Intracranial Pressure |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D000074743 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Hemodynamic Monitoring |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D006801 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Humans |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D008297 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Male |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D005260 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Female |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D000328 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Adult |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D008875 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Middle Aged |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D000368 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Aged |
| type | article |
| title | Cerebral perfusion pressure targets after traumatic brain injury: a reappraisal |
| awards[0].id | https://openalex.org/G3029669851 |
| awards[0].funder_id | https://openalex.org/F4320320924 |
| awards[0].display_name | |
| awards[0].funder_award_id | 225270 |
| awards[0].funder_display_name | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung |
| awards[1].id | https://openalex.org/G5933092546 |
| awards[1].funder_id | https://openalex.org/F4320319990 |
| awards[1].display_name | |
| awards[1].funder_award_id | NIHR203312* |
| awards[1].funder_display_name | National Institute for Health and Care Research |
| biblio.issue | 1 |
| biblio.volume | 29 |
| biblio.last_page | 207 |
| biblio.first_page | 207 |
| topics[0].id | https://openalex.org/T10706 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2728 |
| topics[0].subfield.display_name | Neurology |
| topics[0].display_name | Traumatic Brain Injury and Neurovascular Disturbances |
| topics[1].id | https://openalex.org/T10645 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9965999722480774 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2711 |
| topics[1].subfield.display_name | Emergency Medicine |
| topics[1].display_name | Cardiac Arrest and Resuscitation |
| topics[2].id | https://openalex.org/T11406 |
| topics[2].field.id | https://openalex.org/fields/28 |
| topics[2].field.display_name | Neuroscience |
| topics[2].score | 0.9957000017166138 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2804 |
| topics[2].subfield.display_name | Cellular and Molecular Neuroscience |
| topics[2].display_name | Cerebrospinal fluid and hydrocephalus |
| funders[0].id | https://openalex.org/F4320319990 |
| funders[0].ror | https://ror.org/0187kwz08 |
| funders[0].display_name | National Institute for Health and Care Research |
| funders[1].id | https://openalex.org/F4320320924 |
| funders[1].ror | https://ror.org/00yjd3n13 |
| funders[1].display_name | Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung |
| is_xpac | False |
| apc_list.value | 2390 |
| apc_list.currency | GBP |
| apc_list.value_usd | 2931 |
| apc_paid.value | 2390 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 2931 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8621068596839905 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C111774379 |
| concepts[1].level | 3 |
| concepts[1].score | 0.8083591461181641 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1364253 |
| concepts[1].display_name | Autoregulation |
| concepts[2].id | https://openalex.org/C2781017439 |
| concepts[2].level | 2 |
| concepts[2].score | 0.7856261730194092 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1995526 |
| concepts[2].display_name | Traumatic brain injury |
| concepts[3].id | https://openalex.org/C84359808 |
| concepts[3].level | 4 |
| concepts[3].score | 0.7029155492782593 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q13365173 |
| concepts[3].display_name | Cerebral autoregulation |
| concepts[4].id | https://openalex.org/C154281038 |
| concepts[4].level | 3 |
| concepts[4].score | 0.6761871576309204 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q629232 |
| concepts[4].display_name | Cerebral perfusion pressure |
| concepts[5].id | https://openalex.org/C157767197 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5577020645141602 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q886843 |
| concepts[5].display_name | Cerebral blood flow |
| concepts[6].id | https://openalex.org/C165455791 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5508317947387695 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7002299 |
| concepts[6].display_name | Neurointensive care |
| concepts[7].id | https://openalex.org/C42219234 |
| concepts[7].level | 1 |
| concepts[7].score | 0.4733086824417114 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q131130 |
| concepts[7].display_name | Anesthesia |
| concepts[8].id | https://openalex.org/C146957229 |
| concepts[8].level | 2 |
| concepts[8].score | 0.42060238122940063 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q1266915 |
| concepts[8].display_name | Perfusion |
| concepts[9].id | https://openalex.org/C126322002 |
| concepts[9].level | 1 |
| concepts[9].score | 0.3624853491783142 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[9].display_name | Internal medicine |
| concepts[10].id | https://openalex.org/C84393581 |
| concepts[10].level | 2 |
| concepts[10].score | 0.3347206711769104 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q82642 |
| concepts[10].display_name | Blood pressure |
| concepts[11].id | https://openalex.org/C194828623 |
| concepts[11].level | 1 |
| concepts[11].score | 0.33434808254241943 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q2861470 |
| concepts[11].display_name | Emergency medicine |
| concepts[12].id | https://openalex.org/C164705383 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3200377821922302 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q10379 |
| concepts[12].display_name | Cardiology |
| concepts[13].id | https://openalex.org/C118552586 |
| concepts[13].level | 1 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q7867 |
| concepts[13].display_name | Psychiatry |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.8621068596839905 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/autoregulation |
| keywords[1].score | 0.8083591461181641 |
| keywords[1].display_name | Autoregulation |
| keywords[2].id | https://openalex.org/keywords/traumatic-brain-injury |
| keywords[2].score | 0.7856261730194092 |
| keywords[2].display_name | Traumatic brain injury |
| keywords[3].id | https://openalex.org/keywords/cerebral-autoregulation |
| keywords[3].score | 0.7029155492782593 |
| keywords[3].display_name | Cerebral autoregulation |
| keywords[4].id | https://openalex.org/keywords/cerebral-perfusion-pressure |
| keywords[4].score | 0.6761871576309204 |
| keywords[4].display_name | Cerebral perfusion pressure |
| keywords[5].id | https://openalex.org/keywords/cerebral-blood-flow |
| keywords[5].score | 0.5577020645141602 |
| keywords[5].display_name | Cerebral blood flow |
| keywords[6].id | https://openalex.org/keywords/neurointensive-care |
| keywords[6].score | 0.5508317947387695 |
| keywords[6].display_name | Neurointensive care |
| keywords[7].id | https://openalex.org/keywords/anesthesia |
| keywords[7].score | 0.4733086824417114 |
| keywords[7].display_name | Anesthesia |
| keywords[8].id | https://openalex.org/keywords/perfusion |
| keywords[8].score | 0.42060238122940063 |
| keywords[8].display_name | Perfusion |
| keywords[9].id | https://openalex.org/keywords/internal-medicine |
| keywords[9].score | 0.3624853491783142 |
| keywords[9].display_name | Internal medicine |
| keywords[10].id | https://openalex.org/keywords/blood-pressure |
| keywords[10].score | 0.3347206711769104 |
| keywords[10].display_name | Blood pressure |
| keywords[11].id | https://openalex.org/keywords/emergency-medicine |
| keywords[11].score | 0.33434808254241943 |
| keywords[11].display_name | Emergency medicine |
| keywords[12].id | https://openalex.org/keywords/cardiology |
| keywords[12].score | 0.3200377821922302 |
| keywords[12].display_name | Cardiology |
| language | en |
| locations[0].id | doi:10.1186/s13054-025-05458-9 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S191417626 |
| locations[0].source.issn | 1364-8535, 1466-609X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1364-8535 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Critical Care |
| locations[0].source.host_organization | https://openalex.org/P4310320256 |
| locations[0].source.host_organization_name | BioMed Central |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320256, https://openalex.org/P4310319965 |
| locations[0].source.host_organization_lineage_names | BioMed Central, Springer Nature |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05458-9 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Critical Care |
| locations[0].landing_page_url | https://doi.org/10.1186/s13054-025-05458-9 |
| locations[1].id | pmh:oai:pubmedcentral.nih.gov:12096506 |
| locations[1].is_oa | True |
| locations[1].source.id | https://openalex.org/S2764455111 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed Central |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | other-oa |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | Text |
| locations[1].license_id | https://openalex.org/licenses/other-oa |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Crit Care |
| locations[1].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12096506 |
| locations[2].id | pmid:40399968 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306525036 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | publishedVersion |
| locations[2].raw_type | |
| locations[2].license_id | |
| locations[2].is_accepted | True |
| locations[2].is_published | True |
| locations[2].raw_source_name | Critical care (London, England) |
| locations[2].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40399968 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5081004828 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5386-0811 |
| authorships[0].author.display_name | Stefan Yu Bögli |
| authorships[0].countries | CH, GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[0].affiliations[0].raw_affiliation_string | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. [email protected]. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I202697423, https://openalex.org/I4210100468 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Neurology and Neurocritical Care Unit, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland. [email protected]. |
| authorships[0].institutions[0].id | https://openalex.org/I4210100468 |
| authorships[0].institutions[0].ror | https://ror.org/01462r250 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210100468 |
| authorships[0].institutions[0].country_code | CH |
| authorships[0].institutions[0].display_name | University Hospital of Zurich |
| authorships[0].institutions[1].id | https://openalex.org/I202697423 |
| authorships[0].institutions[1].ror | https://ror.org/02crff812 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I202697423 |
| authorships[0].institutions[1].country_code | CH |
| authorships[0].institutions[1].display_name | University of Zurich |
| authorships[0].institutions[2].id | https://openalex.org/I241749 |
| authorships[0].institutions[2].ror | https://ror.org/013meh722 |
| authorships[0].institutions[2].type | education |
| authorships[0].institutions[2].lineage | https://openalex.org/I241749 |
| authorships[0].institutions[2].country_code | GB |
| authorships[0].institutions[2].display_name | University of Cambridge |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Stefan Yu Bögli |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. [email protected]., Department of Neurology and Neurocritical Care Unit, Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland. [email protected]. |
| authorships[1].author.id | https://openalex.org/A5048802392 |
| authorships[1].author.orcid | https://orcid.org/0009-0009-8283-305X |
| authorships[1].author.display_name | Ihsane Olakorede |
| authorships[1].countries | GB |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[1].affiliations[0].raw_affiliation_string | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| authorships[1].institutions[0].id | https://openalex.org/I241749 |
| authorships[1].institutions[0].ror | https://ror.org/013meh722 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[1].institutions[0].country_code | GB |
| authorships[1].institutions[0].display_name | University of Cambridge |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ihsane Olakorede |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| authorships[2].author.id | https://openalex.org/A5078001149 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Erta Beqiri |
| authorships[2].countries | GB |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[2].affiliations[0].raw_affiliation_string | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| authorships[2].institutions[0].id | https://openalex.org/I241749 |
| authorships[2].institutions[0].ror | https://ror.org/013meh722 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[2].institutions[0].country_code | GB |
| authorships[2].institutions[0].display_name | University of Cambridge |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Erta Beqiri |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| authorships[3].author.id | https://openalex.org/A5036370695 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-6000-3914 |
| authorships[3].author.display_name | Xuhang Chen |
| authorships[3].countries | GB |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[3].affiliations[0].raw_affiliation_string | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| authorships[3].institutions[0].id | https://openalex.org/I241749 |
| authorships[3].institutions[0].ror | https://ror.org/013meh722 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[3].institutions[0].country_code | GB |
| authorships[3].institutions[0].display_name | University of Cambridge |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Xuhang Chen |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| authorships[4].author.id | https://openalex.org/A5068584979 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8832-918X |
| authorships[4].author.display_name | Andrea Lavinio |
| authorships[4].countries | GB |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK. |
| authorships[4].institutions[0].id | https://openalex.org/I241749 |
| authorships[4].institutions[0].ror | https://ror.org/013meh722 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[4].institutions[0].country_code | GB |
| authorships[4].institutions[0].display_name | University of Cambridge |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Andrea Lavinio |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK. |
| authorships[5].author.id | https://openalex.org/A5064523646 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-2796-1835 |
| authorships[5].author.display_name | Peter J. Hutchinson |
| authorships[5].countries | GB |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| authorships[5].institutions[0].id | https://openalex.org/I241749 |
| authorships[5].institutions[0].ror | https://ror.org/013meh722 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[5].institutions[0].country_code | GB |
| authorships[5].institutions[0].display_name | University of Cambridge |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Peter Hutchinson |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| authorships[6].author.id | https://openalex.org/A5113046346 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Peter Smielewski |
| authorships[6].countries | GB |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I241749 |
| authorships[6].affiliations[0].raw_affiliation_string | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| authorships[6].institutions[0].id | https://openalex.org/I241749 |
| authorships[6].institutions[0].ror | https://ror.org/013meh722 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I241749 |
| authorships[6].institutions[0].country_code | GB |
| authorships[6].institutions[0].display_name | University of Cambridge |
| authorships[6].author_position | last |
| authorships[6].raw_author_name | Peter Smielewski |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Brain Physics Laboratory, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05458-9 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Cerebral perfusion pressure targets after traumatic brain injury: a reappraisal |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10706 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2728 |
| primary_topic.subfield.display_name | Neurology |
| primary_topic.display_name | Traumatic Brain Injury and Neurovascular Disturbances |
| related_works | https://openalex.org/W2604389455, https://openalex.org/W1980236775, https://openalex.org/W2318860532, https://openalex.org/W1978082518, https://openalex.org/W4288046334, https://openalex.org/W2792847384, https://openalex.org/W3141732236, https://openalex.org/W2895958443, https://openalex.org/W4376596107, https://openalex.org/W2004607834 |
| cited_by_count | 10 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 10 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1186/s13054-025-05458-9 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S191417626 |
| best_oa_location.source.issn | 1364-8535, 1466-609X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1364-8535 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Critical Care |
| best_oa_location.source.host_organization | https://openalex.org/P4310320256 |
| best_oa_location.source.host_organization_name | BioMed Central |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320256, https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_lineage_names | BioMed Central, Springer Nature |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05458-9 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Critical Care |
| best_oa_location.landing_page_url | https://doi.org/10.1186/s13054-025-05458-9 |
| primary_location.id | doi:10.1186/s13054-025-05458-9 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S191417626 |
| primary_location.source.issn | 1364-8535, 1466-609X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1364-8535 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Critical Care |
| primary_location.source.host_organization | https://openalex.org/P4310320256 |
| primary_location.source.host_organization_name | BioMed Central |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320256, https://openalex.org/P4310319965 |
| primary_location.source.host_organization_lineage_names | BioMed Central, Springer Nature |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://ccforum.biomedcentral.com/counter/pdf/10.1186/s13054-025-05458-9 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Critical Care |
| primary_location.landing_page_url | https://doi.org/10.1186/s13054-025-05458-9 |
| publication_date | 2025-05-21 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2522738478, https://openalex.org/W3139496128, https://openalex.org/W3184555459, https://openalex.org/W2069973528, https://openalex.org/W2093569692, https://openalex.org/W2321296273, https://openalex.org/W2742465404, https://openalex.org/W4377137588, https://openalex.org/W4367368833, https://openalex.org/W2612652617, https://openalex.org/W4200217948, https://openalex.org/W2152626368, https://openalex.org/W2344156974, https://openalex.org/W2587638651, https://openalex.org/W2901462518, https://openalex.org/W4404913992, https://openalex.org/W4405885529, https://openalex.org/W4397049594, https://openalex.org/W2023601064, https://openalex.org/W2022036219, https://openalex.org/W2049487312, https://openalex.org/W4405588736, https://openalex.org/W4387041419, https://openalex.org/W4394568161, https://openalex.org/W2161864397, https://openalex.org/W2039885590, https://openalex.org/W4281484074, https://openalex.org/W2064795783, https://openalex.org/W2887702453, https://openalex.org/W2108451834, https://openalex.org/W2074894149, https://openalex.org/W4205703637, https://openalex.org/W6805578222, https://openalex.org/W3197151935, https://openalex.org/W4391480932, https://openalex.org/W4320857777, https://openalex.org/W2898888900, https://openalex.org/W4389734251, https://openalex.org/W4409125789, https://openalex.org/W4386325937, https://openalex.org/W4312190624, https://openalex.org/W2973577713, https://openalex.org/W3195714029, https://openalex.org/W4220731429, https://openalex.org/W2005333810, https://openalex.org/W4404956599, https://openalex.org/W4407879534, https://openalex.org/W2792477371, https://openalex.org/W2103874803, https://openalex.org/W4200452291 |
| referenced_works_count | 50 |
| abstract_inverted_index.( | 307 |
| abstract_inverted_index.= | 268, 366 |
| abstract_inverted_index.a | 24 |
| abstract_inverted_index.p | 263, 267, 308, 365 |
| abstract_inverted_index.OR | 288 |
| abstract_inverted_index.We | 141 |
| abstract_inverted_index.an | 93, 217 |
| abstract_inverted_index.as | 332, 385, 413 |
| abstract_inverted_index.at | 53 |
| abstract_inverted_index.be | 60, 73, 118, 338 |
| abstract_inverted_index.in | 224, 279, 324, 343 |
| abstract_inverted_index.is | 7, 30 |
| abstract_inverted_index.it | 29 |
| abstract_inverted_index.no | 317 |
| abstract_inverted_index.of | 26, 48, 88, 133, 174, 196, 273, 289, 352, 405 |
| abstract_inverted_index.on | 110 |
| abstract_inverted_index.or | 39, 178 |
| abstract_inverted_index.to | 9, 106, 127, 150, 243, 319, 381, 387 |
| abstract_inverted_index.we | 125 |
| abstract_inverted_index.(CI | 248, 252, 291, 295 |
| abstract_inverted_index.(OR | 246 |
| abstract_inverted_index.18% | 353 |
| abstract_inverted_index.45% | 355 |
| abstract_inverted_index.809 | 143 |
| abstract_inverted_index.CPP | 70, 115, 123, 136, 175, 280, 382, 399, 407, 416 |
| abstract_inverted_index.LLA | 286, 305, 330 |
| abstract_inverted_index.Our | 214, 369 |
| abstract_inverted_index.PRx | 76, 225 |
| abstract_inverted_index.TBI | 145, 376 |
| abstract_inverted_index.The | 271, 392 |
| abstract_inverted_index.ULA | 83, 166 |
| abstract_inverted_index.and | 58, 82, 85, 139, 158, 165, 190, 199, 209, 228, 250, 257, 266, 293, 300, 329, 409 |
| abstract_inverted_index.are | 378 |
| abstract_inverted_index.can | 59, 72 |
| abstract_inverted_index.for | 254, 297, 356, 397 |
| abstract_inverted_index.had | 159 |
| abstract_inverted_index.may | 117 |
| abstract_inverted_index.the | 19, 36, 40, 46, 64, 111, 130, 134, 184, 187, 191, 285, 325, 333, 395, 414 |
| abstract_inverted_index.vs. | 354, 360 |
| abstract_inverted_index.who | 152 |
| abstract_inverted_index.< | 264, 309 |
| abstract_inverted_index.1.04 | 247 |
| abstract_inverted_index.1.09 | 251 |
| abstract_inverted_index.1.11 | 290 |
| abstract_inverted_index.1.26 | 294 |
| abstract_inverted_index.2002 | 149 |
| abstract_inverted_index.2023 | 151 |
| abstract_inverted_index.CPP. | 108, 234 |
| abstract_inverted_index.Even | 235 |
| abstract_inverted_index.LLA, | 81, 164 |
| abstract_inverted_index.aims | 52 |
| abstract_inverted_index.away | 281 |
| abstract_inverted_index.care | 11 |
| abstract_inverted_index.data | 91, 215 |
| abstract_inverted_index.dose | 189, 256, 299 |
| abstract_inverted_index.flow | 57 |
| abstract_inverted_index.from | 75, 148, 176, 282 |
| abstract_inverted_index.less | 119 |
| abstract_inverted_index.more | 99, 379 |
| abstract_inverted_index.need | 396 |
| abstract_inverted_index.only | 229 |
| abstract_inverted_index.than | 121 |
| abstract_inverted_index.that | 113, 375, 402 |
| abstract_inverted_index.this | 33 |
| abstract_inverted_index.time | 193, 259, 302 |
| abstract_inverted_index.were | 167, 181, 240 |
| abstract_inverted_index.when | 43 |
| abstract_inverted_index.with | 98, 103, 221, 226, 232, 276, 287, 340, 345, 358 |
| abstract_inverted_index.work | 373 |
| abstract_inverted_index.(CPP) | 5 |
| abstract_inverted_index.0.001 | 265, 269 |
| abstract_inverted_index.Based | 109 |
| abstract_inverted_index.Brain | 20 |
| abstract_inverted_index.CPP), | 80 |
| abstract_inverted_index.Limit | 335 |
| abstract_inverted_index.Lower | 334 |
| abstract_inverted_index.While | 18 |
| abstract_inverted_index.above | 389 |
| abstract_inverted_index.adult | 144 |
| abstract_inverted_index.after | 13 |
| abstract_inverted_index.aimed | 126 |
| abstract_inverted_index.below | 238, 261, 304, 384 |
| abstract_inverted_index.blood | 56 |
| abstract_inverted_index.brain | 15 |
| abstract_inverted_index.could | 337 |
| abstract_inverted_index.dose, | 186 |
| abstract_inverted_index.fixed | 177 |
| abstract_inverted_index.index | 67 |
| abstract_inverted_index.limit | 38, 87, 363 |
| abstract_inverted_index.lower | 37, 122, 362, 406, 415 |
| abstract_inverted_index.mmHg, | 28 |
| abstract_inverted_index.prism | 47 |
| abstract_inverted_index.range | 34 |
| abstract_inverted_index.small | 236 |
| abstract_inverted_index.spent | 194, 260, 303 |
| abstract_inverted_index.these | 197, 349 |
| abstract_inverted_index.those | 344 |
| abstract_inverted_index.upper | 86 |
| abstract_inverted_index.using | 63, 169, 201, 411 |
| abstract_inverted_index.value | 132 |
| abstract_inverted_index.worse | 244, 320, 341 |
| abstract_inverted_index.(PRx). | 68 |
| abstract_inverted_index.(TBI). | 17 |
| abstract_inverted_index.(lower | 84 |
| abstract_inverted_index.CPPopt | 78, 239, 283, 313, 328, 412 |
| abstract_inverted_index.Trauma | 21 |
| abstract_inverted_index.around | 96 |
| abstract_inverted_index.higher | 114 |
| abstract_inverted_index.hourly | 188, 255, 298 |
| abstract_inverted_index.injury | 16 |
| abstract_inverted_index.level, | 42 |
| abstract_inverted_index.levels | 116, 314, 408 |
| abstract_inverted_index.limit. | 417 |
| abstract_inverted_index.linked | 242 |
| abstract_inverted_index.modest | 230 |
| abstract_inverted_index.showed | 316 |
| abstract_inverted_index.target | 25 |
| abstract_inverted_index.tests, | 203 |
| abstract_inverted_index.viewed | 44 |
| abstract_inverted_index.0.001). | 310 |
| abstract_inverted_index.0.003). | 367 |
| abstract_inverted_index.6-month | 161 |
| abstract_inverted_index.60–70 | 27 |
| abstract_inverted_index.CPP/PRx | 219 |
| abstract_inverted_index.CPPopt, | 97, 163, 262 |
| abstract_inverted_index.Margin) | 336 |
| abstract_inverted_index.Results | 213 |
| abstract_inverted_index.between | 327, 348 |
| abstract_inverted_index.central | 8 |
| abstract_inverted_index.derived | 74 |
| abstract_inverted_index.further | 277 |
| abstract_inverted_index.harmful | 120 |
| abstract_inverted_index.levels, | 124 |
| abstract_inverted_index.methods | 140 |
| abstract_inverted_index.optimal | 41 |
| abstract_inverted_index.ordinal | 207 |
| abstract_inverted_index.outside | 195 |
| abstract_inverted_index.overall | 185 |
| abstract_inverted_index.results | 393 |
| abstract_inverted_index.steeper | 222 |
| abstract_inverted_index.suggest | 410 |
| abstract_inverted_index.targets | 71, 180, 198, 350 |
| abstract_inverted_index.through | 45 |
| abstract_inverted_index.towards | 284 |
| abstract_inverted_index.unclear | 31 |
| abstract_inverted_index.whether | 32 |
| abstract_inverted_index.(optimal | 79 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Cerebral | 2 |
| abstract_inverted_index.Distinct | 322 |
| abstract_inverted_index.Emerging | 90 |
| abstract_inverted_index.Material | 138 |
| abstract_inverted_index.admitted | 147 |
| abstract_inverted_index.analyzed | 142 |
| abstract_inverted_index.assessed | 182 |
| abstract_inverted_index.cerebral | 55 |
| abstract_inverted_index.compared | 105, 386 |
| abstract_inverted_index.confirms | 216 |
| abstract_inverted_index.distance | 347 |
| abstract_inverted_index.examined | 200 |
| abstract_inverted_index.findings | 370 |
| abstract_inverted_index.invasive | 154 |
| abstract_inverted_index.logistic | 204 |
| abstract_inverted_index.margins, | 364 |
| abstract_inverted_index.outcomes | 245, 342 |
| abstract_inverted_index.patients | 146, 357, 377 |
| abstract_inverted_index.pressure | 4, 65, 156 |
| abstract_inverted_index.reassess | 128 |
| abstract_inverted_index.reflects | 35 |
| abstract_inverted_index.strength | 272 |
| abstract_inverted_index.suggests | 92 |
| abstract_inverted_index.targets. | 137 |
| abstract_inverted_index.analyses, | 208 |
| abstract_inverted_index.available | 160 |
| abstract_inverted_index.avoidance | 404 |
| abstract_inverted_index.decreases | 237, 278 |
| abstract_inverted_index.different | 135 |
| abstract_inverted_index.estimated | 61, 168 |
| abstract_inverted_index.generally | 315 |
| abstract_inverted_index.heatmaps, | 206 |
| abstract_inverted_index.highlight | 394 |
| abstract_inverted_index.including | 77 |
| abstract_inverted_index.increased | 275 |
| abstract_inverted_index.increases | 223 |
| abstract_inverted_index.outcomes. | 162, 321 |
| abstract_inverted_index.perfusion | 3 |
| abstract_inverted_index.published | 171 |
| abstract_inverted_index.traumatic | 14 |
| abstract_inverted_index.underwent | 153 |
| abstract_inverted_index.(Mortality | 351 |
| abstract_inverted_index.Conclusion | 368 |
| abstract_inverted_index.Deviations | 173 |
| abstract_inverted_index.Foundation | 22 |
| abstract_inverted_index.asymmetric | 94, 218 |
| abstract_inverted_index.decreasing | 104, 227, 346, 361 |
| abstract_inverted_index.describing | 183 |
| abstract_inverted_index.elevations | 231, 388 |
| abstract_inverted_index.hypothesis | 112 |
| abstract_inverted_index.identified | 339 |
| abstract_inverted_index.increasing | 107, 233, 359 |
| abstract_inverted_index.management | 6, 12, 400 |
| abstract_inverted_index.modelling. | 212 |
| abstract_inverted_index.monitoring | 157 |
| abstract_inverted_index.percentage | 192, 258, 301 |
| abstract_inverted_index.previously | 170 |
| abstract_inverted_index.prioritize | 403 |
| abstract_inverted_index.prognostic | 131 |
| abstract_inverted_index.pronounced | 100 |
| abstract_inverted_index.reactivity | 66 |
| abstract_inverted_index.recommends | 23 |
| abstract_inverted_index.reductions | 383 |
| abstract_inverted_index.rigorously | 129 |
| abstract_inverted_index.strategies | 401 |
| abstract_inverted_index.suggesting | 374 |
| abstract_inverted_index.trajectory | 211 |
| abstract_inverted_index.vulnerable | 380 |
| abstract_inverted_index.(introduced | 331 |
| abstract_inverted_index.Chi-squared | 202 |
| abstract_inverted_index.Conversely, | 311 |
| abstract_inverted_index.association | 274, 318 |
| abstract_inverted_index.corroborate | 371 |
| abstract_inverted_index.group-based | 210 |
| abstract_inverted_index.higher-than | 312 |
| abstract_inverted_index.stabilizing | 54 |
| abstract_inverted_index.thresholds. | 391 |
| abstract_inverted_index.1.02–1.06) | 249 |
| abstract_inverted_index.1.04–1.15) | 253 |
| abstract_inverted_index.1.07–1.14) | 292 |
| abstract_inverted_index.1.18–1.35) | 296 |
| abstract_inverted_index.Introduction | 1 |
| abstract_inverted_index.Personalized | 69 |
| abstract_inverted_index.consistently | 241 |
| abstract_inverted_index.continuously | 62 |
| abstract_inverted_index.experimental | 372 |
| abstract_inverted_index.intracranial | 155 |
| abstract_inverted_index.personalized | 179, 390 |
| abstract_inverted_index.regressions, | 205 |
| abstract_inverted_index.relationship | 95, 220, 326 |
| abstract_inverted_index.respectively | 306 |
| abstract_inverted_index.trajectories | 323 |
| abstract_inverted_index.deterioration | 102 |
| abstract_inverted_index.neurocritical | 10 |
| abstract_inverted_index.Autoregulation | 51 |
| abstract_inverted_index.autoregulation | 101 |
| abstract_inverted_index.individualized | 398 |
| abstract_inverted_index.methodologies. | 172 |
| abstract_inverted_index.respectively). | 270 |
| abstract_inverted_index.autoregulation. | 50 |
| abstract_inverted_index.cerebrovascular | 49 |
| abstract_inverted_index.autoregulation). | 89 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 98 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.99614295 |
| citation_normalized_percentile.is_in_top_1_percent | True |
| citation_normalized_percentile.is_in_top_10_percent | True |