Cerebral Vascular Toxicity after Developmental Exposure to Arsenic (As) and Lead (Pb) Mixtures Article Swipe
Keturah Kiper
,
Breeann Mild
,
Jenny Chen
,
Chongli Yuan
,
Ellen M. Wells
,
Wei Zheng
,
Jennifer L. Freeman
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/toxics12090624
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/toxics12090624
Arsenic (As) and lead (Pb) are environmental pollutants found in common sites linked to similar adverse health effects. This study determined driving factors of neurotoxicity on the developing cerebral vasculature with As and Pb mixture exposures. Cerebral vascular toxicity was evaluated at mixture concentrations of As and Pb representing human exposures levels (10 or 100 parts per billion; ppb; µg/L) in developing zebrafish by assessing behavior, morphology, and gene expression. In the visual motor response assay, hyperactivity was observed in all three outcomes in dark phases in larvae with exposure (1–120 h post fertilization, hpf) to 10 ppb As, 10 ppb Pb, or 10 ppb mix treatment. Time spent moving exhibited hyperactivity in dark phases for 100 ppb As and 100 ppb mix treatment groups only. A decreased brain length and ratio of brain length to total length in the 10 ppb mix group was measured with no alterations in other treatment groups or other endpoints (i.e., total larval length, head length, or head width). Alternatively, measurements of cerebral vasculature in the midbrain and cerebellum uncovered decreased total vascularization at 72 hpf in all treatment groups in the mesencephalon and in all treatment groups, except the 100 ppb Pb and 10 ppb As groups, in the cerebellum. In addition, decreased sprouting and branching occurred in the mesencephalon, while only decreased branching was measured in the cerebellum. The 10 ppb Pb group showed several cerebral vasculature modifications that were aligned with a specific gene expression alteration pattern different from other treatment groups. Additionally, the 100 ppb As group drove gene alterations, along with several other endpoints, for changes observed in the 100 ppb mix treatment group. Perturbations assessed in this study displayed non-linear concentration-responses, which are important to consider in environmental health outcomes for As and Pb neurotoxicity.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/toxics12090624
- https://www.mdpi.com/2305-6304/12/9/624/pdf?version=1724468666
- OA Status
- gold
- References
- 127
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401890454
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401890454Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/toxics12090624Digital Object Identifier
- Title
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Cerebral Vascular Toxicity after Developmental Exposure to Arsenic (As) and Lead (Pb) MixturesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-08-24Full publication date if available
- Authors
-
Keturah Kiper, Breeann Mild, Jenny Chen, Chongli Yuan, Ellen M. Wells, Wei Zheng, Jennifer L. FreemanList of authors in order
- Landing page
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https://doi.org/10.3390/toxics12090624Publisher landing page
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https://www.mdpi.com/2305-6304/12/9/624/pdf?version=1724468666Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2305-6304/12/9/624/pdf?version=1724468666Direct OA link when available
- Concepts
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Arsenic, Toxicity, Lead exposure, Environmental chemistry, Lead poisoning, Lead (geology), Chemistry, Medicine, Biology, Internal medicine, Psychiatry, Paleontology, Organic chemistry, CATSTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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127Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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